55439-11-7

Upstream product

• 22514-82-5 2,3-diphenyl quinoline 
• 64-19-7 acetic acid 
• 64-17-5 ethanol 
• 3193-62-2 N-benzyl-1-phenylethylamine 
• 704200-89-5 2-(2-methoxyphenyl)-1-phenylethan-1-amine 
• 612-16-8 (2-methoxyphenyl)methanol 
• 52289-93-7 o-Methoxybenzyl bromide 
• 100-52-7 benzaldehyde 
• 5344-90-1 2-Aminobenzyl alcohol 
• 451-40-1 phenyl benzyl ketone 

Relevant academic research and scientific papers

Highly Diastereo- And Enantioselective Ir-Catalyzed Hydrogenation of 2,3-Disubstituted Quinolines with Structurally Fine-Tuned Phosphine-Phosphoramidite Ligands

A highly diastereo- and enantioselective Ir-catalyzed hydrogenation of unfunctionalized 2,3-disubstituted quinolines, especially 3-alkyl-2-arylquinolines, has been realized. The success of this hydrogenation is ascribed to the use of a structurally fine-tuned chiral phosphine-phosphoramidite ligand with a (Sa)-3,3′-dimethyl H8-naphthyl moiety and (Rc)-1-phenylethylamine backbone. The hydrogenation displayed broad functional group tolerance, thus furnishing a wide range of optically active 2,3-disubstituted tetrahydroquinolines in up to 96% ee and with perfect cis-diastereoselectivity.

Nucleophilic Amination of Methoxy Arenes Promoted by a Sodium Hydride/Iodide Composite

A method for the nucleophilic amination of methoxy arenes was established by using sodium hydride (NaH) in the presence of lithium iodide (LiI). This method offers an efficient route to benzannulated nitrogen heterocycles. Mechanistic studies showed that the reaction proceeds through an unusual concerted nucleophilic aromatic substitution.