55745-83-0

Basic information

• Product Name: 2-PIPERAZIN-1-YL-BENZOTHIAZOLE
• Synonyms: TIMTEC-BB SBB007362;2-PIPERAZIN-1-YL-1,3-BENZOTHIAZOLE;2-PIPERAZIN-1-YL-BENZOTHIAZOLE;2-PIPERAZINO-1,3-BENZOTHIAZOLE;CHEMBRDG-BB 4003354;BUTTPARK 51\07-05;3-(Piperazin-1-yl)-1,2-benzisothiazole;Benzothiazole, 2-(1-piperazinyl)- (9CI)
• CAS NO: 55745-83-0
• Molecular Formula: C₁₁H₁₃N₃S
• Molecular Weight: 219.31
• Product Categories: BENZOTHIAZOLE
• Mol File: 55745-83-0.mol
• Article Data: 28

Chemical Properties

• Melting Point: 75-79℃
• Boiling Point: 370.5 °C at 760 mmHg
• Flash Point: 177.9 °C
• Appearance: /
• Density: 1.256
• Vapor Pressure: 1.1E-05mmHg at 25°C
• Refractive Index: 1.655
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 8.33±0.10(Predicted)
• CAS DataBase Reference: 2-PIPERAZIN-1-YL-BENZOTHIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PIPERAZIN-1-YL-BENZOTHIAZOLE(55745-83-0)
• EPA Substance Registry System: 2-PIPERAZIN-1-YL-BENZOTHIAZOLE(55745-83-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 55745-83-0(Hazardous Substances Data)

Usage

Uses

2-(1-Piperazinyl)benzothiazole is a useful compound in the study of 1,8-Naphthyridone derivatives as potential inhibitor of HIV-1 replication.

InChI:InChI=1/C11H13N3S/c1-2-4-10-9(3-1)13-11(15-10)14-7-5-12-6-8-14/h1-4,12H,5-8H2

Upstream product

• 110-85-0 piperazine 
• 615-20-3 2-chlorobenzo[d][1,3]thiazole 
• 87691-87-0 3-(1-piperazinyl)-1,2-benzisothiazole 
• 615-22-5 2-methylmercaptobenzothiazole 
• 95-16-9 1,3-Benzothiazole 
• 2516-40-7 2-bromo-1,3-benzothiazole 
• 232263-41-1 ethyl 4-(benzothiazol-2-yl)-piperazin-1-carboxylate 
• 498-94-2 isonipecotic acid 
• 1028328-19-9 2,3 diaminothiophenol 
• 149-30-4 2-Mercaptobenzothiazole 
• 7144-49-2 2-methanesulfonylbenzothiazole 
• 7542-23-6 piperazine hydrochloride 
• 142-64-3 piperazine dihydrochloride 

Downstream Products

• 1616493-17-4 ethyl 7-[4-(1,3-benzothiazol-2-yl)piperazin-1-yl]-1-[2-(4-chlorophenyl)ethyl]-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate 
• 1616493-16-3 ethyl 7-[4-(1,3-benzothiazol-2-yl)piperazin-1-yl]-1-[2-(2-fluorophenyl)ethyl]-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate 
• 1616493-11-8 ethyl 7-[4-(1,3-benzothiazol-2-yl)piperazin-1-yl]-4-oxo-1-[4-(trifluoromethyl)benzyl]-1,4-dihydro-1,8-naphthyridine-3-carboxylate 
• 1616493-10-7 ethyl 7-[4-(1,3-benzothiazol-2-yl)piperazin-1-yl]-1-(4-chlorobenzyl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate 
• 1616493-09-4 ethyl 7-[4-(1,3-benzothiazol-2-yl)piperazin-1-yl]-1-benzyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate 
• 1616493-08-3 ethyl 7-[4-(1,3-benzothiazol-2-yl)piperazin-1-yl]-1-(3-chlorobenzyl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate 

Relevant articles and documents

Piperazine propanol derivative as a novel antifungal targeting 1,3-β-D-glucan synthase

1,3-β-D-Glucan synthase, which synthesizes a main component of fungal cell wall, is one of the promising targets for antifungal agents. In order to identify novel chemical classes of 1,3-β-D-glucan synthase inhibitors, we screened a chemical library monit

Synthesis and evaluation of new 2-piperazinylbnenzothiazoles with high 5-HT(1A) and 5-HT3 affinities

Original 2-piperazinylbenzothiazole derivatives were synthesized and studied as mixed ligands for serotoninergic 5-HT(1A) and 5-HT3 receptors. The studied compounds exhibited significant affinities for these two serotoninergic receptor subtypes. The pharmacological profile of these ligands was agonist for 5-HT(1A) receptors and antagonist for 5-HT3 receptor subsites. Compounds with such a pharmacological profile are of clinical relevance in the treatment of psychotropic diseases (eg anxiety, depression and schizophrenia). The present paper reports the chemistry and the in vitro pharmacological evaluation of these ligands.

Copper(ii) ions supported on functionalized graphene oxide: an organometallic nanocatalyst for oxidative amination of azolesviaC-H/C-N bond activation

Graphene oxide (GO) was chemically modified withpara-aminobenzoic acid (PABA) to immobilize copper(ii) ions on its surface and used as a nanocatalyst for the oxidative C(sp2)-H bond amination reaction. A practical method to prepare Cu2+supported onpara-aminobenzoic acid grafted on GO was reported. The prepared Cu2+@GO/PABA was characterized by FT-IR, XRD, SEM, AFM, TEM, UV-Vis, and ICP techniques. The results showed that the morphology, distribution, and loading of copper ions could be well-adjusted by grafting of PABA on GO. Moreover, just 2 mol% of Cu2+@GO-PABA could catalyze the C-H activation reaction of benzoxazole and benzothiazole with secondary amines in >94% yields. Also, the catalyst showed very good recyclability and much less leaching of the Cu into the reaction solution. The high activity of Cu2+@GO-PABA can be ascribed to the good synergistic effects of Cu2+andpara-aminobenzoic acid grafted on graphene oxide.

Small-compound enhancers for functional O-mannosylation of alpha-dystroglycan, and uses thereof

The present invention provides compounds that can enhance functional O-mannosylation of proteins including alpha-dystroglycan. Also provided are methods of preparation of the compounds defined by the formula I. Also provided are the methods of using the compounds or the pharmaceutical acceptable salts or prodrugs thereof in treating and preventing subjects suffering from the diseases including muscular dystrophies and cancers.