55752-63-1Relevant academic research and scientific papers
Synthesis of 5-aryl-3-(methylsulfanyl)-1H-pyrazoles via three-component reaction of 1,1-bis(methylsulfanyl)-2-nitroethene, aromatic aldehydes, and hydrazine
Alizadeh, Abdolali,Esmaili Zand, Hamid Reza,Saberi, Vahid,Mokhtari, Javad
, p. 2240 - 2244 (2013)
An efficient approach for the preparation of functionalized 5-aryl-3-(methylsulfanyl)-1H-pyrazoles 2 is described. This three-component reaction between benzaldehydes 1, NH2NH2·H 2O, and 1,1-bis(methylsulfanyl)-2-nitroethene proceeds in EtOH under reflux conditions in good-to-excellent yields. The structures of 2 were corroborated spectroscopically (IR, 1H- and 13C-NMR, and EI-MS). A plausible mechanism for this type of reaction is proposed (Scheme 2). Copyright
Catalyst-Free One-Pot Access to Pyrazoles and Disulfide-Tethered Pyrazoles via Deamidative Heteroannulation of β-Ketodithioesters with Semicarbazide Hydrochloride in Water
Koley, Suvajit,Panja, Sumit Kumar,Soni, Sonam,Singh, Maya Shankar
, p. 1780 - 1785 (2018/03/21)
An operationally simple, mild, and catalyst-free one-pot protocol to access privileged pyrazoles and disulfide-tethered pyrazoles has been devised by [3+2] heteroannulation of β-ketodithioesters with semicarbazide hydrochloride in water under open air. The pH of the medium played a key role toward the selectivity switch, as refluxing in water led to the formation of pyrazoles, whereas addition of sodium acetate in water enabled the formation of disulfide-tethered pyrazoles. Notably, this protocol involves a tandem sequence of amination/cyclization/dehydration/hydrodesufurization/hydrolysis/deamidative reactions. A mechanistic rationale for this regio-/chemoselective domino reaction is outlined, which is well supported and validated by density functional theory calculations. (Figure presented.).
Evaluation of [12C/11C]carbon monoxide binding to copper(I) tris(pyrazolyl)borate complexes
Kealey, Steven,White, Andrew J. P.,Gee, Antony D.,Long, Nicholas J.
, p. 1896 - 1905 (2015/04/27)
The copper(I) coordination chemistry of tris(3-R-5-R′-pyrazolyl)borate ligands (TpR,R′) bearing substituent groups attached to the pyrazole rings has been investigated under nitrogen and carbon monoxide atmospheres [1 (TpPh,SMe) R =
PYRAZOLYL SUBSTITUTED CARBONIC ACID DERIVATIVES AS MODULATORS OF THE PROSTACYCLIN(PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
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Page/Page column 117-118, (2010/07/02)
Pyrazole derivatives of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pulmonary arterial hypertension (PAH) and related disorders; platelet aggregation; coronary artery disease; myocardial infarction; transient ischemic attack; angina; stroke; ischemia-reperfusion injury; restenosis; atrial fibrillation; blood clot formation in an angioplasty or coronary bypass surgery individual or in an individual suffering from atrial fibrillation; atherosclerosis; atherothrombosis; asthma or a symptom thereof; a diabetic-related disorder such as diabetic peripheral neuropathy, diabetic nephropathy or diabetic retinopathy; glaucoma or other disease of the eye with abnormal intraocular pressure; hypertension; inflammation; psoriasis; psoriatic arthritis; rheumatoid arthritis; Crohn's disease; transplant rejection; multiple sclerosis; systemic lupus erythematosus (SLE); ulcerative colitis; ischemia-reperfusion injury; restenosis; atherosclerosis; acne; type 1 diabetes; type 2 diabetes; sepsis; and chronic obstructive pulmonary disorder (COPD).
Substituted pyrazoles
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, (2008/06/13)
New and valuable substituted pyrazoles, herbicides containing these compounds as active ingredients, and a process for controlling the growth of unwanted plants with these compounds.
