55894-16-1

Basic information

• Product Name: Phosphonium, (2-methoxyethyl)triphenyl-, bromide
• Synonyms: Nsc280056;Phosphonium, (2-methoxyethyl)triphenyl-, bromide;(2-Methoxyethyl)triphenylphosphoniuM broMide;(2-Methoxyethyl)(triphenyl)phosphoniuM;Phosphonium, (2-methoxyethyl)triphenyl-, bromide (1:1)
• CAS NO: 55894-16-1
• Molecular Formula: Br*C₂₁H₂₂OP
• Molecular Weight: 401.276541
• Mol File: 55894-16-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 216 °C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: g/cm³
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: Phosphonium, (2-methoxyethyl)triphenyl-, bromide(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonium, (2-methoxyethyl)triphenyl-, bromide(55894-16-1)
• EPA Substance Registry System: Phosphonium, (2-methoxyethyl)triphenyl-, bromide(55894-16-1)

Safety Data

• Hazardous Substances Data: 55894-16-1(Hazardous Substances Data)

Usage

Uses

(2-Methoxyethyl)triphenylphosphonium Bromide is an intermediate for the synthesis of (Z)-Triprolidine Oxalate Salt (T814007), which is an antihistaminic agent with anticholinergic properties. Triprolidine is used to treat and prevent symptoms associated with allergies. Triprolidine is also used in combination with cold medicine to provide relief for flu-like symptoms.

InChI:InChI=1/C21H22OP/c1-22-17-18-23(19-11-5-2-6-12-19,20-13-7-3-8-14-20)21-15-9-4-10-16-21/h2-16H,17-18H2,1H3/q+1

Upstream product

• 67-56-1 methanol 
• 7237-34-5 2-(hydroxyethyl)triphenylphosphonium bromide 
• 603-35-0 triphenylphosphine 
• 6482-24-2 2-Bromoethyl methyl ether 
• 540-51-2 2-bromoethanol 

Downstream Products

• 21331-80-6 [2-(dimethylamino)ethyl]triphenylphosphonium bromide 
• 21277-56-5 [2-(N-piperidino)ethyl]triphenylphosphonium bromide 
• 21331-68-0 [2-(N-morpholino)ethyl]triphenylphosphonium bromide 
• 16277-67-1 (Z)-(3-methoxyprop-1-en-1-yl)benzene 
• 1226985-13-2 (1E,3Z)-(5-methoxypenta-1,3-dienyl)benzene 
• 112655-08-0 ((1E,3E)-5-methoxypenta-1,3-dien-1-yl)benzene 
• 1122568-72-2 tert-butyl [3-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}-2-(4-{3-[3-methoxyprop-1-en-1-yl]pyridin-2-yl}-2-methylphenyl)propyl]carbamate 
• 887-21-8 2-(diphenylphosphinyl)ethanol 
• 4336-76-9 (β-methoxyethyl)diphenylphosphine oxide 
• 23896-93-7 (α-methylbenzyl)diphenylphosphine oxide 
• 791-28-6 Triphenylphosphine oxide 
• 2096-78-8 vinyldiphenylphosphine oxide 
• 1476-07-9 cinnamyl ethyl ether 

Relevant articles and documents

2,6-diisopropylphenol compound as well as preparation method and application thereof

The invention relates to a 2,6-diisopropylphenol compound as well as a preparation method and application thereof. The invention particularly relates to a compound shown as a general formula (A) in the description, a preparation method and application of the compound in preparation of anesthetic drugs and drugs for treating cerebral arterial thrombosis. The compound shown in the formula A is characterized in that an olefinic bond in the formula is of a trans-structure; and R1 is selected from CH2OR2 and COOR3.

A PROCESS FOR THE SYNTHESIS OF (E) -2-[1 - (4 - METHYL PHENYL) -3-(1-PYRRONYL)-1 - PROPENYL] PYRIDINE (TRIPROLIDINE)

A Process for the synthesis of (E) - 2 - [1 - (4 - methyl phenyl) -3- (1- pyrrolidinyl)-l- propenyl] pyridine (TRIPROLIDINE) by reacting 2-(l-pyrrolidino)ethyl triphenyl phosphonium bromide with 2-(p-toluoyl) pyridine in presence of aprotic solvent and a base, isomeising in presence of acid catalyst.

Pyrrolidinic and piperidinic ring fission by conjugate elimination

Treating N-substituted pyrrolidines and piperidines bearing an allylic chain α to the nitrogen with strong bases leads to the opening of the heterocycle and provides 1,3-dienes disubstituted with an alkoxy and an aminoalkyl chain. The effects of the base and the solvent have been studied, as well as the influence of the ring size and the nitrogen substituent. The results obtained suggest a possible pre-chelation of the base cation before the deprotonation.