21331-80-6

Usage

Uses

Used in Polymer and Material Science Industry:
(2-DIMETHYLAMINOETHYL)TRIPHENYLPHOSPHONIUM BROMIDE is used as a polymerizable cationic surfactant for the intercalation of montmorillonite (MMT). This application is crucial in the synthesis of polystyrene-clay nanocomposite materials, which have improved properties such as enhanced mechanical strength, thermal stability, and barrier properties compared to their pure polymer counterparts.
Used in Pharmaceutical Chemistry:
(2-DIMETHYLAMINOETHYL)TRIPHENYLPHOSPHONIUM BROMIDE is used as a key intermediate in the synthesis of some analogs of morphine 6-glucuronide. This application is significant in pharmaceutical chemistry, as these analogs have potential therapeutic uses, particularly in the management of pain and addiction. The use of Wittig reactions in their synthesis allows for the creation of a variety of structurally diverse compounds with potential medicinal properties.

InChI:InChI=1/C22H25NP.BrH/c1-23(2)18-19-24(20-12-6-3-7-13-20,21-14-8-4-9-15-21)22-16-10-5-11-17-22;/h3-17H,18-19H2,1-2H3;1H/q+1;/p-1

Upstream product

• 108-01-0 2-(N,N-dimethylamino)ethanol 
• 603-35-0 triphenylphosphine 
• 55894-16-1 (2-methoxyethyl)triphenylphosphonium bromide 
• 124-40-3 dimethyl amine 

Downstream Products

• 33962-90-2 N,N-dimethylcinnamylamine 
• 75712-94-6 (Z)-N,N-dimethyl-3-phenylprop-2-en-1-amine 
• 42817-44-7 (E)-N,N-dimethyl-3-phenylprop-2-en-1-amine 
• 139938-18-4 Dimethyl-((E)-3-phenyl-3-pyridazin-3-yl-allyl)-amine 
• 681171-41-5 {6-[4-(3-dimethylamino-propenyl)-5-ethyl-2-methoxy-phenyl]-pyridin-2-yl}-carbamic acid tert-butyl ester 
• 886042-21-3 (2Z)-2-[14-cyclohexyl-11-(methoxycarbonyl)-6H-indolo[1,2-e][1,5]benzoxazocin-7(8H)-ylidene]-N,N-dimethylethanaminium trifluoroacetate 
• 886042-19-9 (2Z)-2-[14-cyclohexyl-11-(methoxycarbonyl)-6H-indolo[1,2-e][1,5]benzoxazocin-7(8H)-ylidene]-N,N-dimethylethanaminiumtrifluoroacetate 
• 205582-30-5 [(dimethylamino)ethyl]triphenylphosphonium bromide 
• 423166-75-0 Acetic acid 4-[(E)-1-(4'-bromo-biphenyl-4-yl)-3-dimethylamino-propenyl]-phenyl ester 

Relevant academic research and scientific papers

Heterocyclic compound serving as SOS1 inhibitor

The invention provides a compound serving as an SOS1 inhibitor, and particularly provides a compound with a structure as shown in a formula (I), or an optical isomer, a pharmaceutically acceptable salt, a prodrug, a deuterated derivative, a hydrate and a solvate of the compound. The compound can be used for treating or preventing diseases or symptoms related to the activity or expression quantity of SOS1.

Chlorpheniramine Analogues Reverse Chloroquine Resistance in Plasmodium falciparum by Inhibiting PfCRT

The emergence and spread of malaria parasites that are resistant to chloroquine (CQ) has been a disaster for world health. The antihistamine chlorpheniramine (CP) partially resensitizes CQ-resistant (CQR) parasites to CQ but possesses little intrinsic antiplasmodial activity. Mutations in the parasite's CQ resistance transporter (PfCRT) confer resistance to CQ by enabling the protein to transport the drug away from its site of action, and it is thought that resistance-reversers such as CP exert their effect by blocking this CQ transport activity. Here, a series of new structural analogues and homologues of CP have been synthesized. We show that these compounds (along with other in vitro CQ resistance-reversers) inhibit the transport of CQ via a resistance-conferring form of PfCRT expressed in Xenopus laevis oocytes. Furthermore, the level of PfCRT-inhibition was found to correlate well with both the restoration of CQ accumulation and the level of CQ resensitization in CQR parasites.

Synthesis of 2-(N-disubstituted amino)ethyltriphenylphosphonium bromides

2-(N-Disubstituted amino)ethyltriphenylphosphonium bromides are prepared in quantitative yields with high purity by reacting secondary amines with 2-methoxyethyltriphenylphosphonium bromide under aqueous conditions. The differential reactivity of this reagent offers advantages for the preparation of aminoethyltriphenylphosphonium bromides possessing nucleophiles such as hydroxy groups.

PREPARATION DE SELS D'AMINOALKYLPHOSPHONIUMS

Three synthetic methods have been applied to prepare amino phosphonium salts: (C6H5)3P+-(CH2)n-N-.The best ways have been determined for different n values and different substituents on the nitrogen atom.In all cases, yields are better with n=3, but no intramolecular stabilization has been detected.