55895-91-5

Upstream product

• 17849-31-9 2-chloro-3-(4-nitrophenyl)propionitrile 
• 100-97-0 hexamethylenetetramine 
• 1991-83-9 4-nitrophenylalanine 
• 126862-00-8 ethyl N-(diphenylmethylene)-DL-(p-nitrophenyl)alaninate 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 6265-86-7 formylamino-(4-nitro-benzyl)-malonic acid diethyl ester 
• 100-14-1 4-nitrobenzyl chloride 
• 163251-51-2 2-amino-3-(4-nitrophenyl)propionic acid ethyl ester hydrochloride 

Downstream Products

• 89288-22-2 2-amino-3-(4-nitrophenyl)propan-1-ol 
• 326019-69-6 dichloroacetic acid-[(R or S)-1-hydroxymethyl-2-(4-nitro-phenyl)-ethylamide] 
• 740844-68-2 2-hydroxy-3-(4-nitro-phenyl)-propionic acid ethyl ester 

Relevant academic research and scientific papers

Sequential C-N and C-O bond formation in a single pot: Synthesis of 2 H -benzo[ b ][1,4]oxazines from 2,5-dihydroxybenzaldehyde and amino acid precursors

Functionalized β-aryl alanine ester derivatives were found to undergo rapid C-N and C-O bond formation with quinol carbonyl compounds to afford 2H-benzo[b][1,4]oxazines in good to excellent yields. This unprecedented finding reported herein offers a straightforward, highly efficient, and rapid method for the synthesis of 2H-benzo[b][1,4]oxazines.

Efficient synthesis of α-substituted amino acid ester: Alkylation and hydrogenation removal of Schiff's base protecting group

A general and efficient synthetic route to α-amino acids by alkylation of the sodium salt of Schiff base ester 1 has been described previously. The α-substituted ethyl glycinates 4a-g are prepared in excellent yield by a two-step sequence involving regios

Compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them

The present invention relates to novel antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds of formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them.

Ethyl N-(diphenylmethylene)glycinate as anionic glycine equivalent. Monoalkylation, dialkylation and michael additions under solid-liquid phase-transfer catalysis

Ethyl N-(diphenylmethylene)glycinate, 1, undergoes monoalkylations, dialkylations and Michael additions to ethylenic and acetylenic acceptors under appropriate solid-liquid phase transfer catalysis conditions. Further transformations of the α-disubstituted ketimines lead to α-alkylated aspartic and glutamic acid derivatives 10, 15, 19 and 26, to bicyclic amino acids or derivatives featuring pyrazolone and isoxazolone moieties 30 and 33, and to α-substituted (E)-3,4-dehydroglutamic acids. Copyright

Synthesis of α-substituted and α,α-disubstituted α-amino acids by controlled mono- and dialkylation of ethyl N-diphenylmethyleneglycinate

Ethyl N-diphenylmethyleneglycinate reacts with one equivalent of alkylating agents in the presence of powdered potassium carbonate to afford, after hydrolysis, monoalkylated glycine esters. A similar process using two equivalents of alkylating agents in t