5626-90-4Relevant academic research and scientific papers
Inhibition of carbonic anhydrase II by sulfonamide derivatives
Li, W.,Xuan, G. S.,Zhan, J. H.,Zhang, A. M.,Zheng, K.
, p. 412 - 415 (2021/11/22)
A series of sulfonamide derivatives were synthesized, and the enzyme inhibitory activity of the synthesized compounds on carbonic anhydrase II was evaluated. Through molecular docking studies, it was found that compounds 1b, 1e, 2a, 2b, 3a have a strong binding affinity to carbonic anhydrase II. The IC50 values of the four compounds 1e, 2b, 3a, and 3b were lower than that of the positive control drug acetazolamide. What’s more, the compounds had a high inhibitory activity for A549 lung cancer cell growth, among them, 1e and 3a could inhibit both carbonic anhydrase II and lung cancer cell proliferation.
Structural, spectroscopic and nonlinear optical properties of sulfonamide derivatives; experimental and theoretical study
Arshad, Muhammad Nadeem,Faidallah, Hassan M.,Asiri, Abdullah M.,Kosar, Naveen,Mahmood, Tariq
, (2019/11/26)
Nonlinear optical (NLO) materials have broad range applications in the field of optoelectronic devices. Nowadays great interest has been developed for synthesizing the compounds having high NLO response. Herein we are reporting the structural, spectroscopic and NLO properties of two, structurally simple sulfonamide derivatives. Both compounds are synthesized in respectable yields, characterized by using NMR (1H and 13C), FT-IR and UV–vis spectroscopic techniques. X-ray diffraction analysis confirmed the final structures. Density functional theory (DFT) at B3LYP/6-31G(d,p) method are performed for validation of experimental data (X-ray as well as spectroscopic data). Absorption studies of both compounds are performed by using TD-DFT method. Coefficients of the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) of both compounds reflect the high stability. First hyperpolarizability (βo), polarizability (αo) and dipole moment (μ) analyses calculated at LC-BLYP method revealed that both derivatives have reasonable nonlinear optical (NLO) response. The static, dc-Kerr effect and electric field-induced second harmonic generation (ESHG) hyperpolarizability co-efficient are also studied for refractive index (n2) calculation of both sulfonamides, to further observe their NLO response.
Catalytic activity of magnetic Fe3O4@Diatomite earth and acetic acid for the N-acylation of sulfonamides
Ghasemi, Mohammad Hadi,Kowsari, Elaheh,Hosseini, Seyed Kiumars
supporting information, p. 387 - 391 (2016/01/12)
The Br?nsted and Lewis acidic promoted N-acylation of sulfonamides with acetic anhydride or benzoyl chloride has been achieved using glacial acetic acid and magnetic Fe3O4@Diatomite earth. Use of acetic acid as solvent omits the need for organic bases and permits the isolation of products by filtration and precipitation. Additionally, the magnetic composite Fe3O4@Diatomite acts as a conjugate proton super acid, enabling the acylation of sulfonamide compounds.
Compound capable of inhibiting activity of NEDD8 kinase as well as preparation method and pharmaceutical application of compound
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Paragraph 0160; 0161; 0162, (2016/10/10)
The invention belongs to the field of medicines and in particular relates to a compound with the structure of a formula I, a stereomer of the compound or pharmaceutically acceptable salts of the compound as well as a preparation method of the compound and application of the compound to preparation of anti-tumor medicines. A pharmacological experiment result shows that the compound can be used for inhibiting the activity of NEDD8 kinase and has the inhibition effect on proliferation of a plurality of types of tumor cells, so that the compound can be used as an NEDD8 kinase activity inhibitor for preparing the anti-tumor medicines. The formula I is shown in the description.
Identification of a β1/β2-Specific Sulfonamide Proteasome Ligand by Crystallographic Screening
Beck, Philipp,Reboud-Ravaux, Michèle,Groll, Michael
supporting information, p. 11275 - 11278 (2016/07/06)
The proteasome represents a validated drug target for the treatment of cancer, however, new types of inhibitors are required to tackle the development of resistant tumors. Current fluorescence-based screening methods suffer from low sensitivity and are limited to the detection of ligands with conventional binding profiles. In response to these drawbacks, a crystallographic screening procedure for the discovery of agents with a novel mode of action was utilized. The optimized workflow was applied to the screening of a focused set of compounds, resulting in the discovery of a β1/β2-specific sulfonamide derivative that noncovalently binds between subunits β1 and β2. The binding pocket displays significant differences in size and polarity between the immuno- and constitutive proteasome. The identified ligand thus provides valuable insights for the future structure-based design of subtype-specific proteasome inhibitors.
Acylation of benzenesulfamides in alkaline solutions
Kotlyar,Gorodnyuk,Grigorash,Zlotskii
, p. 1653 - 1654 (2007/10/03)
Acylation of 4-aminobenzenesulfamide with acetic anhydride in aqueous sodium hydroxide was studied, and the main acylation products were determined.
Footprint Catalysis. II. Molecular Recognition of Footprint Catalytic Sites
Morihara, Kensaku,Nishihata, Emiko,Kojima, Mari,Miyake, Sayoko
, p. 3999 - 4004 (2007/10/02)
In order to investigate the molecular recognition capability of "footprint" catalytic sites, the affinities of nine "footprint" catalysts for eleven competitive inhibitors, closely related to template molecules, were estimated through the competitive inhibition constants, Ki .An examination of the affinity revealed that the recognition by "footprint" catalytic sites was so highly specific that it could recognize not only the whole, but also the partial, stuctures of the bound molecules.
