562823-66-9Relevant articles and documents
An enantioselective synthesis of the C1-C9 segment of antitumor macrolide peloruside A
Ghosh, Arun K.,Kim, Jae-Hun
, p. 3967 - 3969 (2007/10/03)
A stereocontrolled synthesis of the C1-C9 segment of the marine natural product peloruside A is described. The key steps involve Sharpless's catalytic asymmetric dihydroxylation reaction, a chelation-controlled reduction of chiral β-alkoxy ketones to elaborate the syn-1,3-diol functionality and a ring-closing olefin metathesis of a homoallylic alcohol-derived acrylate ester to form an α,β-unsaturated δ-lactone.