562823-58-9Relevant articles and documents
A facile approach for the synthesis of C13-C24 fragments of maltepolides A, C and D
Rao, P. Sankara,Srihari
, p. 9629 - 9638 (2016/10/22)
A linear, chiron approach for the synthesis of C13-C24 fragments of cytostatic maltepolides A, C and D consisting of a tetrahydrofuran subunit and a chiral alkenyl/alkyl substituent is achieved from (+)-diethyl l-tartrate. The other chiral stereocenters were generated by employing key reactions such as Crimmins aldol, alkynylation and CeCl3·7H2O mediated Luche reduction reactions.
An enantioselective synthesis of the C1-C9 segment of antitumor macrolide peloruside A
Ghosh, Arun K.,Kim, Jae-Hun
, p. 3967 - 3969 (2007/10/03)
A stereocontrolled synthesis of the C1-C9 segment of the marine natural product peloruside A is described. The key steps involve Sharpless's catalytic asymmetric dihydroxylation reaction, a chelation-controlled reduction of chiral β-alkoxy ketones to elaborate the syn-1,3-diol functionality and a ring-closing olefin metathesis of a homoallylic alcohol-derived acrylate ester to form an α,β-unsaturated δ-lactone.