56292-99-0

Basic information

• Product Name: 8-Methoxy-1,4-dioxaspiro[4.5]decane
• Synonyms: 8-Methoxy-1,4-dioxaspiro[4.5]decane;4-METHOXYCYCLOHEXANONE ETHYLENE KETAL
• CAS NO: 56292-99-0
• Molecular Formula: C₉H₁₆O₃
• Molecular Weight: 172.22
• Mol File: 56292-99-0.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 8-Methoxy-1,4-dioxaspiro[4.5]decane(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Methoxy-1,4-dioxaspiro[4.5]decane(56292-99-0)
• EPA Substance Registry System: 8-Methoxy-1,4-dioxaspiro[4.5]decane(56292-99-0)

Safety Data

• Hazardous Substances Data: 56292-99-0(Hazardous Substances Data)

Upstream product

• 22428-87-1 4,4-ethylenedioxycyclohexan-1-ol 
• 74-88-4 methyl iodide 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 637-88-7 1,4-Cyclohexanedione 
• 13482-23-0 4-methoxycyclohexanone 
• 107-21-1 ethylene glycol 
• 556-48-9 1,4-Cyclohexanediol 
• 18068-06-9 4-methoxycyclohexan-1-ol 

Downstream Products

• 4746-97-8 cyclohexanedione monoethylene ketal 
• 120552-57-0 4-methoxycyclohexane-1-carbaldehyde 
• 1342811-26-0 C₁₃H₁₇BrN₂O 
• 100610-99-9 4-methoxycyclohexanone (2,4-dinitrophenyl)hydrazone 
• 56292-98-9 C₇H₁₀⁽²⁾H₄O₂ 
• 56292-97-8 C₇H₁₃⁽²⁾HO₂ 

Relevant articles and documents

PYRIMIDINE-BASED ANTIPROLIFERATIVE AGENTS

This invention is in the area of pyrimidine-based compounds for the treatment of disorders involving abnormal cellular proliferation, including but not limited to tumors and cancers.

ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF

Described herein are compounds of Formula (S-I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein are useful for inhibiting arginine methyltransferase activity. Methods of using the compounds for treating arginine methyltransferase-mediated disorders are also described.

Spectroscopic and X-ray crystallographic evidence for electrostatic effects in 4-substituted cyclohexanone-derived hydrazones, imines, and corresponding salts

The axial conformer of several 4-substituted cyclo-hexanone hydrazone salts was found to predominate in solution. Changes in the charge of the molecule and the polarity of the solvent led to changes in the conformational preference of each molecule that were consistent with electrostatic stabilization of the axial conformer. H NMR spectroscopic analysis was utilized to determine the structure of cyclohexanone-derived substrates by comparison to conformationally restricted trans-decalone derivatives and computational models. X-ray crystallography demonstrated that the axial configuration of a pendant benzyloxy group is the preferred conformation of an iminium ion in the solid state. The structure of a neutral hydrazone was also determined to favor the axial configuration for a pendant benzyloxy group in the solid state.