5665-20-3Relevant articles and documents
Enantioselective α-Benzylation of Acyclic Esters Using π-Extended Electrophiles
Schwarz, Kevin J.,Yang, Chao,Fyfe, James W. B.,Snaddon, Thomas N.
supporting information, p. 12102 - 12105 (2018/09/11)
The first asymmetric cooperative Lewis base/palladium catalyzed benzylic alkylation of acyclic esters is reported. This reaction proceeds via stereodefined C1-ammonium enolate nucleophiles. Critical to its success was the identification of benzylic phosphate electrophiles, which were uniquely reactive. Alkylated products were obtained with very high levels of enantioselectivity, and this method has been applied toward the synthesis of the thrombin inhibitor DX-9065a.
Synthesis of Naphthoquinolizidines - Analogs of Cryptopleurine
Mukerjee, Y. N.,Gaur, S. P.,Jain, P. C.,Anand, Nitya
, p. 985 - 987 (2007/10/02)
Condensation of the appropriate bromomethylnaphthalene (I) with 2-(1,3-dioxa-2-cyclopentyl)pyridine followed by treatment with 48percent HBr affords 3-methoxynaphthoquinolizinium bromide (8), 3-methoxy-(9)-, 2-methoxy-(10)- and 2,3-dimethoxy-(11)-naphthoquinolizinium bromides.The compounds (8-11) on catalytic hydrogenation over PtO2 give the corresponding naphthoquinolizidines (12-15).None of these compounds show any significant anticancer activity.
