72908-01-1 Usage
General Description
2-(carbamylmethyl)-8-hydroxy-3H-cyclopenta(a)naphthalene is a chemical compound with a highly complex structure. It contains a carbamylmethyl group, a hydroxy group, and a cyclopenta(a)naphthalene ring system. 2-(carbamylmethyl)-8-hydroxy-3H-cyclopenta(a)naphthalene is likely to have a variety of biological activities due to its structural features, including potential interactions with proteins, enzymes, and nucleic acids. The presence of a hydroxy group suggests that it may have some level of solubility in water, while the cyclopenta(a)naphthalene ring system is a polycyclic aromatic hydrocarbon, which may confer certain chemical and physical properties. The specific biological and chemical properties of this compound, however, would need to be further investigated through experimental studies.
Check Digit Verification of cas no
The CAS Registry Mumber 72908-01-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,9,0 and 8 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 72908-01:
(7*7)+(6*2)+(5*9)+(4*0)+(3*8)+(2*0)+(1*1)=131
131 % 10 = 1
So 72908-01-1 is a valid CAS Registry Number.
InChI:InChI=1/C15H13NO2/c16-15(18)7-9-5-11-2-1-10-3-4-12(17)8-14(10)13(11)6-9/h1-4,6,8,17H,5,7H2,(H2,16,18)
72908-01-1Relevant articles and documents
New cyclopenta[a]naphthalene derivatives: Synthesis of 2-(carbamylmethyl)-8-hydroxy-3H-cyclopenta[a]naphthalene as a possible deoxyribonucleic acid binding agent
Kundu
, p. 512 - 516 (2007/10/02)
8-Methoxy-1-oxo-2,3-dihydro-1H-cyclopental[a]naphthalene (4) was converted to the oxalyl derivative (7) by treatment with diethyl oxalate in the presence of sodium ethoxide. Compound 7 in the form of the sodium salt was alkylated with ethyl bromoacetate in DMF to 2-(carbethoxymethyl)-8-methoxy-1-oxo-2,3-dihydro-1H-cyclopenta[a]naphthalene (8). Treatment of 8 with methanolic ammonia yielded the corresponding amide (9). Dealkylation of 8 with 48% HBr and subsequent esterification gave compound 10. Ammonolysis of 10 led to the amide 11, which after reduction and subsequent dehydration of the reduced product afforded the desired compound, 2-(carbamylmethyl)-8-hydroxy-3H-cyclopenta[a]naphthalene (2). Compound 2 was found to be mildly growth inhibitory to L1210 and CCRF-CEM leukemic cells in culture. From thermal transition temperature studies, compound 2 was found to bind to calf thymus DNA and the poly(deoxyribonucleotides), e.g., poly(dG)-poly(dC), poly(dG-dC), poly(dA)-poly(dT), and poly (dA-dT).
