569-81-3

Basic information

• Product Name: 1H-Isoindole-1,3(2H)-dione, 2-(4-fluorophenyl)-
• CAS NO: 569-81-3
• Molecular Formula: C14H8FNO2
• Molecular Weight: 241.221
• Mol File: 569-81-3.mol
• Article Data: 32

Chemical Properties

• CAS DataBase Reference: 1H-Isoindole-1,3(2H)-dione, 2-(4-fluorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-1,3(2H)-dione, 2-(4-fluorophenyl)-(569-81-3)
• EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 2-(4-fluorophenyl)-(569-81-3)

Safety Data

• Hazardous Substances Data: 569-81-3(Hazardous Substances Data)

Usage

Chemical structure

1H-Isoindole-1,3(2H)-dione, 2-(4-fluorophenyl)-

Type of compound

Derivative of isoindoline

Usage

Commonly used in pharmaceutical research

Potential applications

COX-2 inhibitor (anti-inflammatory and analgesic properties), cancer treatment and other diseases (requires further research)

Status

Investigational, not yet approved for medicinal use

Upstream product

• 201230-82-2 carbon monoxide 
• 83306-62-1 (E)-N-benzylidene-4-fluorobenzenamine 
• 100-52-7 benzaldehyde 
• 371-40-4 4-fluoroaniline 
• 119072-55-8 tert-butylisonitrile 
• 2042-37-7 o-cyanobromobenzene 
• 524-38-9 N-hydroxyphthalimide 
• 136918-14-4 phthalimide 
• 462-06-6 fluorobenzene 
• 3481-09-2 N-chlorophthalimide 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 85-44-9 phthalic anhydride 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 1074-82-4 potassium phtalimide 

Downstream Products

• 366-75-6 N-(4-fluorophenyl)benzamide 
• 132868-74-7 2,3-Dihydro-3-oxo-2-(p-fluorophenyl)-1H-isoindole-1-acetyl Chloride 
• 132868-72-5 2,3-Dihydro-3-oxo-2-(p-fluorophenyl)-1H-isoindole-1-acetic Acid 
• 132868-71-4 2,3-Dihydro-3-hydroxy-2-(p-fluorophenyl)-1H-isoindol-1-one 

Relevant articles and documents

Electroselective and Controlled Reduction of Cyclic Imides to Hydroxylactams and Lactams

An efficient and practical electrochemical method for selective reduction of cyclic imides has been developed using a simple undivided cell with carbon electrodes at room temperature. The reaction provides a useful strategy for the rapid synthesis of hydroxylactams and lactams in a controllable manner, which is tuned by electric current and reaction time, and exhibits broad substrate scope and high functional group tolerance even to reduction-sensitive moieties. Initial mechanistic studies suggest that the approach heavily relies on the utilization of amines (e.g., i-Pr2NH), which are able to generate α-aminoalkyl radicals. This protocol provides an efficient route for the cleavage of C-O bonds under mild conditions with high chemoselectivity.

Method for one-step constructing N-(4-fluorophenyl) phthalimide by utilizing imine as initial raw material

The invention discloses a method for one-step constructing N-(4-fluorophenyl) phthalimide by utilizing imine as an initial raw material. According to the method, (E)-N-(4-fluorophenyl)-1-phenyl methylenimine is taken as a reaction raw material and is subj

Br?nsted acid mediated intramolecular cyclopropane ring expansion/[4 + 2]-cycloaddition

A cascade reaction of 3-hydroxy-2-phenylisoindolin-1-one and cyclopropyl ketone has been developed via a Br?nsted acid-promoted ring-opening/intramolecular cross-cycloaddition/[4 + 2]-cycloaddition process. The developed methodology provides straightforward access to pentacyclic isoindolin-1-one derivatives under simple reaction conditions.