57181-90-5

Usage

Uses

Used in Chemical Synthesis:
4-(PhenoxyMethyl)aniline is utilized as an intermediate in the synthesis of a wide range of organic compounds. Its presence in the production process is crucial for creating dyes, pharmaceuticals, and agrochemicals, which are essential in their respective industries.
Used in Polymer and Resin Production:
4-(PHENOXYMETHYL)ANILINE also serves as a building block in the manufacturing of polymers and resins. Its incorporation into these materials contributes to their overall properties and performance, making it a valuable component in the production process.
Used as a Corrosion Inhibitor:
4-(PhenoxyMethyl)aniline has potential applications as a corrosion inhibitor, which is vital for protecting metal surfaces from degradation and extending the lifespan of various structures and equipment.
Used as an Antioxidant:
In addition to its other uses, 4-(PHENOXYMETHYL)ANILINE can function as an antioxidant, which is important for preventing the oxidation of materials and maintaining their quality and integrity over time.
Used as a Reagent in Organic Synthesis:
4-(PhenoxyMethyl)aniline is also employed as a reagent in organic synthesis, playing a key role in various chemical reactions and processes.
Safety Precautions:
It is important to handle 4-(PhenoxyMethyl)aniline with care, as it may pose risks if ingested, inhaled, or comes into contact with the skin. Additionally, it may be harmful to aquatic life, so proper disposal and containment measures should be taken to minimize environmental impact.

Upstream product

• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 108-95-2 phenol 
• 623-04-1 4-aminobenzenemethanol 
• 1373511-73-9 (4-phenoxymethylphenyl)carbamic acid allyl ester 
• 100-14-1 4-nitrobenzyl chloride 
• 99-99-0 1-methyl-4-nitrobenzene 
• 3048-12-2 4-nitrobenzyl phenyl ether 

Downstream Products

• 88089-57-0 3-Bromo-N-(4-phenoxymethyl-phenyl)-propionamide 
• 74119-28-1 4-phenoxymethylphenyl isocyanate 
• 623-04-1 4-aminobenzenemethanol 
• 81461-87-2 N-(p-phenoxymethylphenyl)azetidinone 
• 81461-92-9 1-(4-Iodomethyl-phenyl)-azetidin-2-one 
• 57181-31-4 ethyl 2-chloro-3-(4-phenoxymethylphenyl)propionate 

Relevant academic research and scientific papers

Discovery of 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-phenylacetamide derivatives as new potent and selective human sirtuin 2 inhibitors

Human sirtuin 2 (SIRT2) plays pivotal roles in multiple biological processes such as cell cycle regulation, autophagy, immune and inflammatory responses. Dysregulation of SIRT2 was considered as a main aspect contributing to several human diseases, including cancer. Development of new potent and selective SIRT2 inhibitors is currently desirable, which may provide a new strategy for treatment of related diseases. Herein, a structure-based optimization approach led to new 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-phenylacetamide derivatives as SIRT2 inhibitors. SAR analyses with new synthesized derivatives revealed a number of new potent SIRT2 inhibitors, among which 28e is the most potent inhibitor with an IC50 value of 42?nM. The selectivity analyses found that 28e has a very good selectivity to SIRT2 over SIRT1 and SIRT3. In cellular assays, 28e showed a potent ability to inhibit human breast cancer cell line MCF-7 and increase the acetylation of α-tubulin in a dose-dependent manner. This study will aid further efforts to develop highly potent and selective SIRT2 inhibitors for the treatment of cancer and other related diseases.

N-(4-substituted phenyl)-2-substituted acetamide compound and is use as SIRT2 protein inhibitor

The invention discloses a compound shown in the formula I or its pharmaceutically acceptable salt, crystalline form and solvate. X represents a group shown in the description, Y represents a group shown in the description, R1, R2 and R3 independently represent H, hydroxyl, halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl or phenyl, and R4 represents aryl, heteroaryl, substituted aryl or substituted heteroaryl. The novel compound shown in the formula I has good inhibition activity to SIRT2 and tumors, has a good medicinal value and provides a novel potential choice for clinical medication.

Chemoselective hydrogenation of nitrobenzyl ethers to aminobenzyl ethers catalyzed by palladium-nickel bimetallic nanoparticles

A highly efficient and chemoselective hydrogenation of nitrobenzyl ethers to aminobenzyl ethers was developed by using a novel palladium-nickel bimetallic nanocatalyst. Since the catalytic selectivity was resulted from the synergistic effects between two metals rather than the traditional catalyst poisons, the hydrogenation proceeded smoothly under additive-free conditions. Thus, the work-up procedure was as simple as to recover the catalyst by a magnetic separation and then to evaporate the solvent.

2-Aminobenzothiazole derivatives: Search for new antifungal agents

A new series of 6-substituted 2-aminobenzothiazole derivatives were synthesized and screened in vitro as potential antimicrobials. Almost all the compounds showed antifungal activity. In particular, compounds 1n,o, designed on the basis of molecular modeling studies, were the best of the series, showing MIC values of 4-8 μg/mL against Candida albicans, Candida parapsilosis and Candida tropicalis. None of the two compounds did show any cytotoxicity effect on human THP-1 cells.

Effect of aromaticity on the rate of azaquinone methide-mediated release of benzylic phenols

Herein we use small molecule models of stimuli-induced degradable/ depolymerizable polymers to demonstrate that less aromatic releasing units provide faster rates of azaquinone methide-mediated release of benzylic phenols (a surrogate for a group released in a polymer) than highly aromatic releasing units. Copyright 2013 John Wiley & Sons, Ltd. In small molecule models of stimuli-induced degradable polymers, less aromatic releasing units provide faster rates of azaquinone methide-mediated release of benzylic phenols than highly aromatic releasing units. Copyright

Substituted N-arylazetidinones, β-lactamases potential inhibitors

Two classes of substituted N-aryl azetidinones have been prepared by cyclization of various β-bromopropionanilides. The 7a class possess a carboxylic function in ortho, meta or para of the nitrogen and possibly another alkyl substituent on the aromatic nucleus. In the 7a class, the aromatic nucleus is substituted by a bromomethyl group instead of the alkyl one. Few of these azetidinones show a good affinity for various cell-free β-lactamases preparations, and thus are pretty good competitive inhibitors. Nevertheless, they do not act synergistically with ampicillin on β-lactamase producing bacterial strains. A poor antibacterial activity has been detected for few compounds. The azetidinones 7b which possess a latent electrophilic quinonimine methide function, do not give any progressive (suicide type) inhibition, or inactivation, of the enzymatic activity.