57181-90-5

Basic information

• Product Name: 4-(PHENOXYMETHYL)ANILINE
• Synonyms: Benzenamine, 4-(phenoxymethyl)-
• CAS NO: 57181-90-5
• Molecular Formula: C₁₃H₁₃NO
• Molecular Weight: 199.25
• Mol File: 57181-90-5.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(PHENOXYMETHYL)ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(PHENOXYMETHYL)ANILINE(57181-90-5)
• EPA Substance Registry System: 4-(PHENOXYMETHYL)ANILINE(57181-90-5)

Safety Data

• Hazardous Substances Data: 57181-90-5(Hazardous Substances Data)

Usage

General Description

4-(PhenoxyMethyl)aniline is a chemical compound with the molecular formula C13H13NO. It is an aromatic amine that possesses a phenoxy group and a methyl group attached to a central aniline ring. 4-(PHENOXYMETHYL)ANILINE is commonly used as an intermediate in the synthesis of various organic compounds, including dyes, pharmaceuticals, and agrochemicals. It is also utilized as a building block in the production of polymers and resins. 4-(PhenoxyMethyl)aniline has potential applications as a corrosion inhibitor, antioxidant, and as a reagent in organic synthesis. However, it is important to handle this chemical with caution as it may be harmful if ingested, inhaled, or in contact with the skin, and it may also be harmful to aquatic life.

Upstream product

• 3048-12-2 4-nitrobenzyl phenyl ether 
• 99-99-0 1-methyl-4-nitrobenzene 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 100-14-1 4-nitrobenzyl chloride 
• 108-95-2 phenol 
• 1373511-73-9 (4-phenoxymethylphenyl)carbamic acid allyl ester 
• 623-04-1 4-aminobenzenemethanol 

Downstream Products

• 57181-31-4 ethyl 2-chloro-3-(4-phenoxymethylphenyl)propionate 
• 88089-57-0 3-Bromo-N-(4-phenoxymethyl-phenyl)-propionamide 
• 623-04-1 4-aminobenzenemethanol 
• 74119-28-1 4-phenoxymethylphenyl isocyanate 
• 81461-87-2 N-(p-phenoxymethylphenyl)azetidinone 
• 81461-92-9 1-(4-Iodomethyl-phenyl)-azetidin-2-one 

Relevant articles and documents

Discovery of 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-phenylacetamide derivatives as new potent and selective human sirtuin 2 inhibitors

Human sirtuin 2 (SIRT2) plays pivotal roles in multiple biological processes such as cell cycle regulation, autophagy, immune and inflammatory responses. Dysregulation of SIRT2 was considered as a main aspect contributing to several human diseases, including cancer. Development of new potent and selective SIRT2 inhibitors is currently desirable, which may provide a new strategy for treatment of related diseases. Herein, a structure-based optimization approach led to new 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-phenylacetamide derivatives as SIRT2 inhibitors. SAR analyses with new synthesized derivatives revealed a number of new potent SIRT2 inhibitors, among which 28e is the most potent inhibitor with an IC50 value of 42?nM. The selectivity analyses found that 28e has a very good selectivity to SIRT2 over SIRT1 and SIRT3. In cellular assays, 28e showed a potent ability to inhibit human breast cancer cell line MCF-7 and increase the acetylation of α-tubulin in a dose-dependent manner. This study will aid further efforts to develop highly potent and selective SIRT2 inhibitors for the treatment of cancer and other related diseases.

Chemoselective hydrogenation of nitrobenzyl ethers to aminobenzyl ethers catalyzed by palladium-nickel bimetallic nanoparticles

A highly efficient and chemoselective hydrogenation of nitrobenzyl ethers to aminobenzyl ethers was developed by using a novel palladium-nickel bimetallic nanocatalyst. Since the catalytic selectivity was resulted from the synergistic effects between two metals rather than the traditional catalyst poisons, the hydrogenation proceeded smoothly under additive-free conditions. Thus, the work-up procedure was as simple as to recover the catalyst by a magnetic separation and then to evaporate the solvent.

Effect of aromaticity on the rate of azaquinone methide-mediated release of benzylic phenols

Herein we use small molecule models of stimuli-induced degradable/ depolymerizable polymers to demonstrate that less aromatic releasing units provide faster rates of azaquinone methide-mediated release of benzylic phenols (a surrogate for a group released in a polymer) than highly aromatic releasing units. Copyright 2013 John Wiley & Sons, Ltd. In small molecule models of stimuli-induced degradable polymers, less aromatic releasing units provide faster rates of azaquinone methide-mediated release of benzylic phenols than highly aromatic releasing units. Copyright