5719-08-4

Basic information

• Product Name: 4-chloro-9H-pyrimido[4,5-b]indole
• Synonyms: 4-chloro-9H-pyrimido[4,5-b]indole
• CAS NO: 5719-08-4
• Molecular Formula: C₁₀H₆ClN₃
• Molecular Weight: 203.62774
• Mol File: 5719-08-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 288-290 °C
• Boiling Point: 416.8±25.0 °C(Predicted)
• Appearance: /
• Density: 1.515±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 11.69±0.50(Predicted)
• CAS DataBase Reference: 4-chloro-9H-pyrimido[4,5-b]indole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-9H-pyrimido[4,5-b]indole(5719-08-4)
• EPA Substance Registry System: 4-chloro-9H-pyrimido[4,5-b]indole(5719-08-4)

Safety Data

• Hazardous Substances Data: 5719-08-4(Hazardous Substances Data)

Usage

General Description

4-chloro-9H-pyrimido[4,5-b]indole is an aromatic organic compound with the chemical formula C11H6ClN3. It is a heterocyclic compound consisting of a pyrimidoindole ring system with a chlorine substituent at the 4-position. 4-chloro-9H-pyrimido[4,5-b]indole is a member of the indole family and is used in the synthesis of various pharmaceuticals and agrochemicals. It has also been studied for its potential antitumor and anti-inflammatory properties. Additionally, the structure and properties of 4-chloro-9H-pyrimido[4,5-b]indole make it an interesting candidate for further research in the field of organic chemistry.

Upstream product

• 17466-00-1 7-chloro-3-phenyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine 
• 71-43-2 benzene 
• 6433-72-3 2-amino-1H-indole-3-carboxylic acid ethyl ester 
• 65548-02-9 (+/-)-ethyl cyano(2-nitrophenyl)acetate 
• 88-73-3 2-Chloronitrobenzene 
• 5719-50-6 3,9-dihydro-pyrimido[4,5-b]indol-4-one 
• 113772-13-7 methyl 2-cyano-2-(2-nitrophenyl)acetate 
• 113772-14-8 methyl 2-amino-1H-indole-3-carboxylate 
• 1493-27-2 ortho-nitrofluorobenzene 
• 67-56-1 methanol 

Downstream Products

• 1403589-33-2 4-(furan-2-yl)-9-(2,3,5-tri-O-benzoyl-β-d-ribofuranosyl)-9H-pyrimido[4,5-b]indole 
• 1403589-26-3 4-chloro-9-(2,3,5-tri-O-benzoyl-β-d-ribofuranosyl)-pyrimido[4,5-b]indole 
• 1300026-68-9 N-methyl-3-(1H-pyrimido[4,5-b]indol-4-ylamino)benzenesulfonamide 
• 1351533-50-0 (R)-benzyl (4-(9H-pyrimido[4,5-b]indol-4-yl)morpholin-2-yl)methylcarbamate 

Relevant articles and documents

Design, synthesis, and structure–activity relationships of pyrimido[4,5-b]indole-4-amines as microtubule depolymerizing agents that are effective against multidrug resistant cells

To identify the structural features of 9H-pyrimido[4,5-b]indoles as microtubule depolymerizers, pyrimido[4,5-b]indoles 2–8 with varied substituents at the 2-, 4- and 5-positions were designed and synthesized. Nucleophilic displacement of 2,5-substituted-4

COMPOUNDS AND METHODS

Disclosed are compounds having formula (I), wherein R1, R2, R3, R4, Z1, Z2, Z3 and Z4 are as defined herein, and methods of making and using the same.

TRIAZOLOPYRIMIDINES. VII. THE PHOTOCHEMICAL TRANSFORMATION OF 3-PHENYL-3H-1,2,3-TRIAZOLOPYRIMIDINES INTO 9H-PYRIMIDOINDOLES

The photolysis of 3-phenyl-3H-1,2,3-triazolopyrimidines in dioxane, benzene and methanol gave 9H-pyrimidoindoles in moderate yields.Similarly, 3-phenyl-3H-1,2,3-triazolopyridines were easily transformed by the photolysis into 9H-pyridoindoles.