5719-08-4

Usage

Uses

Used in Pharmaceutical Synthesis:
4-chloro-9H-pyrimido[4,5-b]indole is used as a key intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs with potential therapeutic benefits.
Used in Agrochemical Synthesis:
4-chloro-9H-pyrimido[4,5-b]indole is also utilized in the production of agrochemicals, playing a role in the creation of substances that can enhance crop protection and yield.
Used in Organic Chemistry Research:
4-chloro-9H-pyrimido[4,5-b]indole serves as an interesting subject for research in organic chemistry due to its unique structure and properties, which may lead to advancements in the field.
Used in Antitumor and Anti-inflammatory Studies:
4-chloro-9H-pyrimido[4,5-b]indole has been studied for its potential antitumor and anti-inflammatory properties, indicating its possible use in the development of treatments for cancer and inflammatory conditions.

Upstream product

• 67-56-1 methanol 
• 17466-00-1 7-chloro-3-phenyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine 
• 5719-50-6 3,9-dihydro-pyrimido[4,5-b]indol-4-one 
• 113772-13-7 methyl 2-cyano-2-(2-nitrophenyl)acetate 
• 113772-14-8 methyl 2-amino-1H-indole-3-carboxylate 
• 1493-27-2 ortho-nitrofluorobenzene 
• 88-73-3 2-Chloronitrobenzene 
• 65548-02-9 (+/-)-ethyl cyano(2-nitrophenyl)acetate 
• 6433-72-3 2-amino-1H-indole-3-carboxylic acid ethyl ester 
• 71-43-2 benzene 

Downstream Products

• 1351533-50-0 (R)-benzyl (4-(9H-pyrimido[4,5-b]indol-4-yl)morpholin-2-yl)methylcarbamate 
• 1403589-33-2 4-(furan-2-yl)-9-(2,3,5-tri-O-benzoyl-β-d-ribofuranosyl)-9H-pyrimido[4,5-b]indole 
• 1403589-26-3 4-chloro-9-(2,3,5-tri-O-benzoyl-β-d-ribofuranosyl)-pyrimido[4,5-b]indole 
• 1300026-68-9 N-methyl-3-(1H-pyrimido[4,5-b]indol-4-ylamino)benzenesulfonamide 

Relevant academic research and scientific papers

Design, synthesis, and structure–activity relationships of pyrimido[4,5-b]indole-4-amines as microtubule depolymerizing agents that are effective against multidrug resistant cells

To identify the structural features of 9H-pyrimido[4,5-b]indoles as microtubule depolymerizers, pyrimido[4,5-b]indoles 2–8 with varied substituents at the 2-, 4- and 5-positions were designed and synthesized. Nucleophilic displacement of 2,5-substituted-4

Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides

A series of new pyrimido[4,5-b]indole ribonucleosides bearing phenyl or hetaryl group at position 4 has been prepared by selective Pd-catalyzed cross-coupling reactions of the corresponding protected 4,6-dichloropyrimido[4, 5-b]indole ribonucleoside with (het)arylboronic acids or stannanes followed by deprotection. Further cross-couplings under harsher conditions and employing X-Phos ligand proceeded at the position 6 leading to 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides. Some of these compounds displayed antiviral activity against Dengue virus.

COMPOUNDS AND METHODS

Disclosed are compounds having formula (I), wherein R1, R2, R3, R4, Z1, Z2, Z3 and Z4 are as defined herein, and methods of making and using the same.

9H-PYRIMIDO[4,5-B]INDOLES, 9H-PYRIDO[4',3':4,5]PYRROLO[2,3-D]PYRIDINES, AND 9H-1,3,6,9-TETRAAZA-FLUORENES AS CHK1 KINASE FUNCTION INHIBITORS

The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain tricyclic compounds (referred to herein as TC compounds), and especially certain 9H-pyrimido[4,5-b]indole, 9H-pyrido[4',3':4,5]pyrrolo[2,3-d)p

TRIAZOLOPYRIMIDINES. VII. THE PHOTOCHEMICAL TRANSFORMATION OF 3-PHENYL-3H-1,2,3-TRIAZOLOPYRIMIDINES INTO 9H-PYRIMIDOINDOLES

The photolysis of 3-phenyl-3H-1,2,3-triazolopyrimidines in dioxane, benzene and methanol gave 9H-pyrimidoindoles in moderate yields.Similarly, 3-phenyl-3H-1,2,3-triazolopyridines were easily transformed by the photolysis into 9H-pyridoindoles.