877997-99-4

Basic information

• Product Name: Methyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate
• Synonyms: Methyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate;2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid methyl ester;2-[(2-Hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxylic acid methyl ester;2-[(2-Hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid methyl ester(for Acotiamide)
• CAS NO: 877997-99-4
• Molecular Formula: C₁₄H₁₄N₂O₆S
• Molecular Weight: 338.33576
• EINECS: -0
• Mol File: 877997-99-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: Methyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate(877997-99-4)
• EPA Substance Registry System: Methyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate(877997-99-4)

Safety Data

• Hazardous Substances Data: 877997-99-4(Hazardous Substances Data)

Usage

Uses

Methyl 2-?(2-?Hydroxy-?4,?5-?dimethoxybenzamido)?thiazole-?4-?carboxylate is an Acotiamide (A190260) impurity. Acotiamide is an acetylcholinesterase inhibitor which has been shown to stimulate gastric motility and improve gastric motility dysfunction.

Upstream product

• 61203-48-3 2-iodo-4,5-dimethoxybenzoic acid 
• 6286-46-0 2-bromo-4,5-dimethoxybenzoic acid 
• 93-07-2 Veratric acid 
• 118452-04-3 methyl 2-amino-1,3-thiazole-4-carboxylate 
• 877997-98-3 2-hydroxy-4,5-dimethoxybenzoic acid phenyl ester 
• 5722-93-0 2-hydroxy-4,5-dimethoxybenzoic acid 
• 28373-21-9 2-hydroxy-4,5-dimethoxybenzoic acid methyl ester 
• 610-90-2 2,4,5-trihydroxybenzoic acid 
• 877998-00-0 CH₄O*C₁₄H₁₄N₂O₆S 

Downstream Products

• 185104-11-4 N-[2-(diisopropylamino)ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxamide hydrochloride 
• 185106-16-5 Acotiamide 
• 185104-11-4 2-[N-(4,5-dimethoxy-2-hydroxybenzoyl)amino]-4-[(2-diisopropyl-aminoethyl)aminocarbonyl]-1,3-thiazole hydrochloride 

Relevant articles and documents

Acotiamide hydrochloride preparation method

The invention discloses an acotiamide hydrochloride preparation method. The acotiamide hydrochloride preparation method includes: taking 2,4,5-trihydroxybenzoic acid as a raw material easy to obtain, subjecting methyl iodide to selective methylation react

arab League tests for the amine method of preparing hydrochloric acid

The invention discloses a method for preparing a compound of formula (5). The method comprises the following steps: 1, reacting a compound of formula (2) with triphosgene, diphosgene or phosgene in a non-polar solvent in the presence of an organic alkali to obtain a product, reacting the obtained product with a compound of formula (3) to obtain a compound of formula (1); and 2, reacting the compound of formula (1) with a compound of formula (6) in 1,4-dioxane to obtain a substance, reacting the substance with HCl to form a salt which is the compound of formula (5), wherein R in the compound of formula (3) and the compound of formula (5) is a methyl group or an ethyl group.

METHOD FOR PRODUCING AMINOTHIAZOLE DERIVATIVE AND PRODUCTION INTERMEDIATE

Provided is a method for selectively demethylating a 2-methoxy group. Specifically provided is a production method of a compound represented by formula (7) below through the following reactions.