877997-99-4

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxylate is used as an impurity in Acotiamide, which is an acetylcholinesterase inhibitor. Acotiamide is utilized for its ability to stimulate gastric motility and improve gastric motility dysfunction. The presence of this impurity in Acotiamide may affect the drug's overall effectiveness and safety profile, making it important to monitor and control its levels during the manufacturing process.
In the context of Acotiamide's application, Methyl 2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxylate plays a role in the quality control and assessment of the drug. Ensuring that the levels of this impurity are within acceptable limits is crucial for maintaining the therapeutic benefits and minimizing potential side effects of Acotiamide treatment.

Upstream product

• 118452-04-3 methyl 2-amino-1,3-thiazole-4-carboxylate 
• 28373-21-9 2-hydroxy-4,5-dimethoxybenzoic acid methyl ester 
• 610-90-2 2,4,5-trihydroxybenzoic acid 
• 5722-93-0 2-hydroxy-4,5-dimethoxybenzoic acid 
• 61203-48-3 2-iodo-4,5-dimethoxybenzoic acid 
• 6286-46-0 2-bromo-4,5-dimethoxybenzoic acid 
• 93-07-2 Veratric acid 
• 877997-98-3 2-hydroxy-4,5-dimethoxybenzoic acid phenyl ester 
• 877998-00-0 CH₄O*C₁₄H₁₄N₂O₆S 

Downstream Products

• 185104-11-4 N-[2-(diisopropylamino)ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxamide hydrochloride 
• 185106-16-5 Acotiamide 
• 185104-11-4 2-[N-(4,5-dimethoxy-2-hydroxybenzoyl)amino]-4-[(2-diisopropyl-aminoethyl)aminocarbonyl]-1,3-thiazole hydrochloride 

Relevant academic research and scientific papers

Acotiamide hydrochloride preparation method

The invention discloses an acotiamide hydrochloride preparation method. The acotiamide hydrochloride preparation method includes: taking 2,4,5-trihydroxybenzoic acid as a raw material easy to obtain, subjecting methyl iodide to selective methylation react

arab League tests for the amine method of preparing hydrochloric acid

The invention discloses a method for preparing a compound of formula (5). The method comprises the following steps: 1, reacting a compound of formula (2) with triphosgene, diphosgene or phosgene in a non-polar solvent in the presence of an organic alkali to obtain a product, reacting the obtained product with a compound of formula (3) to obtain a compound of formula (1); and 2, reacting the compound of formula (1) with a compound of formula (6) in 1,4-dioxane to obtain a substance, reacting the substance with HCl to form a salt which is the compound of formula (5), wherein R in the compound of formula (3) and the compound of formula (5) is a methyl group or an ethyl group.

arab League tests for the amine and a method for the preparation of its hydrochloride (by machine translation)

The invention discloses a arab League tests for the amine method for preparing and its hydrochloride, 2 - [(2-hydroxy -4,5-dimethoxy-benzoyl) amino] - 1,3-thiazole-4-carboxylic acid methyl ester, and N, N-diisopropyl ethylenediamin in the molten state after reaction under N-[ 2 - (diisopropyl amino) ethyl] - 2 - [(2-hydroxy -4,5-dimethoxy-benzoyl) amino] - 1,3-thiazole-4-carboxamide, hydrochloric acid for hydrochloric acid prepared by adding dropwisely added methanol trihydrate arab League takes a test for somebody else the amine, the technical proposal of the present invention reduces the use of toluene, economic and convenient, the reaction is complete, process safety; reduced at the same time the residual toluene in the final product, and impurity 2 - [(2-hydroxy -4,5-dimethoxy-benzoyl) amino] - 4-carboxyl -1, the content of 3-thiazole, the product quality is promoted; and is easy to be refined and purification of the crude product, the reaction yield is high. (by machine translation)

METHOD FOR PRODUCING 2-BROMO-4,5-DIALKOXY BENZOIC ACID

Provided is a method for effectively producing a 4,5-dialkoxy-2-hydroxybenzoic acid from an inexpensive raw material. A method for producing a 2-bromo-4,5-dialkoxybenzoic acid represented by the following formula (2): (wherein each of R1 and R2 represents a lower alkyl group), the method including causing a 3,4-dialkoxybenzoic acid represented by the following formula (1): (wherein R1 and R2 have the same meanings as defined above) to react with bromine in concentrated hydrochloric acid.

METHOD FOR PRODUCING AMINOTHIAZOLE DERIVATIVE AND PRODUCTION INTERMEDIATE

Provided is a method for selectively demethylating a 2-methoxy group. Specifically provided is a production method of a compound represented by formula (7) below through the following reactions.

METHOD FOR PRODUCING AMINOTHIAZOLE DERIVATIVE AND PRODUCTION INTERMEDIATE

Disclosed is a selective demethylation process of a 2-methoxy group. Specifically disclosed is a method for producing a compound represented by the formula (7) below through the following reactions.