57238-75-2

Basic information

• Product Name: 5-(CHLOROMETHYL)-3-(4-CHLOROPHENYL)-1,2,4-OXADIAZOLE
• Synonyms: 5-(CHLOROMETHYL)-3-(4-CHLOROPHENYL)-1,2,4-OXADIAZOLE;AKOS BB-7033;BUTTPARK 99\16-13;5-Chloromethyl-3-(4-chloro-phenyl)-;1,2,4-Oxadiazole, 5-(chloromethyl)-3-(4-chlorophenyl)-;10X-0347;ZINC00159206
• CAS NO: 57238-75-2
• Molecular Formula: C₉H₆Cl₂N₂O
• Molecular Weight: 229.06
• Mol File: 57238-75-2.mol
• Article Data: 20

Chemical Properties

• Melting Point: 60 °C
• Boiling Point: 343.8 °C at 760 mmHg
• Flash Point: 161.7 °C
• Appearance: /
• Density: 1.4 g/cm³
• Vapor Pressure: 0.000136mmHg at 25°C
• Refractive Index: 1.574
• Storage Temp.: 2-8°C
• PKA: -2.75±0.37(Predicted)
• CAS DataBase Reference: 5-(CHLOROMETHYL)-3-(4-CHLOROPHENYL)-1,2,4-OXADIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(CHLOROMETHYL)-3-(4-CHLOROPHENYL)-1,2,4-OXADIAZOLE(57238-75-2)
• EPA Substance Registry System: 5-(CHLOROMETHYL)-3-(4-CHLOROPHENYL)-1,2,4-OXADIAZOLE(57238-75-2)

Safety Data

• Hazard Codes: C
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 57238-75-2(Hazardous Substances Data)

Usage

General Description

5-(Chloromethyl)-3-(4-chlorophenyl)-1,2,4-oxadiazole, also known by its chemical formula C9H6Cl2N2O, is a 1,2,4-oxadiazole derivative. It is a heterocyclic compound that contains chlorine and methyl groups, as well as a phenyl ring. This chemical is often used as a building block in the synthesis of various organic compounds, including pharmaceuticals and agrochemicals. Its specific structure and reactivity make it valuable for use in the development of new drugs and other biologically active compounds. Additionally, 5-(Chloromethyl)-3-(4-chlorophenyl)-1,2,4-oxadiazole has shown potential as an antimicrobial and anticancer agent in preliminary research studies, which further highlights its importance in medicinal chemistry.

InChI:InChI=1/C9H6Cl2N2O/c10-5-8-12-9(13-14-8)6-1-3-7(11)4-2-6/h1-4H,5H2

Upstream product

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Downstream Products

• 5372-40-7 3-(4-chlorophenyl)-5-(hydroxymethyl)-1,2,4-oxadiazole 
• 865666-96-2 C₂₃H₁₇ClN₆O₂S 
• 1257542-58-7 C₂₄H₂₁N₇O₂ 
• 531506-44-2 7-[(2-trimethylsilyl)ethoxymethyl]-8-[4-{[3-(4-chlorophenyl)(1,2,4-oxadiazol-5-yl)]methoxy}phenyl]-1,3-dipropyl-1,3,7-trihydropurine-2,6-dione 

Relevant articles and documents

CARBOXY DERIVATIVES WITH ANTIINFLAMMATORY PROPERTIES

The invention relates to compounds of formula (I) and to their use in treating or preventing an inflammatory disease or a disease associated with an undesirable immune response: (I) wherein, RA1, RA2, RC and RD are as defined herein.

One-potCuAAC synthesis of (1H-1,2,3-triazol-1-yl)methyl-1,3,4/1,2,4-oxadiazoles starting from available chloromethyl-1,3,4/1,2,4-oxadiazoles

The one-pot CuAAC synthesis of (1H-1,2,3-triazol-1-yl)methyl-1,3,4-oxadiazole and (1H-1,2,3-triazol-1-yl)methyl-1,2,4-oxadiazole derivatives via three-component reaction of consequent nucleophilic substitution of chlorine, with azide, and its further “cli

Design, synthesis, and bioactivities of novel oxadiazole-substituted pyrazole oximes

A series of novel pyrazole oxime derivatives containing a substituted oxadiazole group were designed and synthesized. The bioassay results indicated that some title compounds displayed good acaricidal and insecticidal activities against Tetranychus cinnabarinus, Aphis medicaginis, Oriental armyworm, and Nilaparvata lugens. Especially, compounds 7a, 7b, and 7c had 80%, 90%, and 90% insecticidal activities against A. medicaginis at 20 μg/mL, respectively. Interestingly, some of the designed compounds displayed wonderful fungicidal activities in vivo against cucumber Pseudoperonospora cubensis. Furthermore, compounds 7a (EC50= 4.97 μg/mL) and 7h (EC50= 0.51 μg/mL) showed excellent fungicidal activity against P. cubensis comparable or better than that of the control Pyraclostrobin (EC50= 4.59 μg/mL).