573945-69-4

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 4746-48-9 2-hydroxy-2,2-diphenylacetonitrile 
• 15485-23-1 N-(4-methoxybenzylidene)-4-bromoaniline 
• 123-11-5 4-methoxy-benzaldehyde 
• 106-40-1 4-bromo-aniline 
• 104-88-1 4-chlorobenzaldehyde 

Relevant academic research and scientific papers

Phosphine-Catalyzed Sequential Michael Addition between α-Aminonitriles and Methyl Acrylate for Cyclization: Synthesis of N-Aryl-Substituted Pyrrolidines

Abstract: N-Aryl-substituted pyrrolidine derivativeswere synthesized via tributylphosphine-catalyzed sequential Michael addition ofα-aminonitriles and methyl acrylate as starting materials. The first Michaeladdition between α-aminonitrile and methyl acryl

Targeted development of hydrophilic porous polysulfonamide gels with catalytic activity

We report the use of a template and functional monomers in the synthesis of three novel polysulfonamide gels with new architectures and functional groups. These mesoporous polysulfonamide gels were prepared by the condensation polymerization of benzene-1,3-disulfonyl chloride (as the main precursor), linear monomers, and cross-linkers (as variable precursors) in the presence of a silica template by a combination of sol-gel chemistry and the nanocasting technique. In this synthesis pathway, in situ polymerization onto the template surface led to the construction of a silica/polymer nanocomposite. Next, after removal of the template, the nanocomposite gels were transformed into mesoporous polysulfonamide nanospheres. After the physicochemical identification of the synthesized materials, functionalized polysulfonamides were used as reusable novel catalysts with high efficiency for the Strecker reaction under mild conditions. These polymers have Br?nsted/Lewis acid active sites, a mesoporous structure, and hydrogen bonding. Moreover, since these polymers are hydrogels that can absorb water, they can promote the Strecker reaction through chemical absorption of the generated water as a driving force. Overall, this article describes a novel synthesis procedure and application of porous polysulfonamide gels.

Mandelic acid catalyzed one-pot three-component synthesis of α-aminonitriles and α-aminophosphonates under solvent-free conditions at room temperature

A simple, mild, straightforward, efficient and eco-friendly protocol has been developed for the synthesis of a series of α-aminonitriles via the one-pot three-component Strecker reactions between various aldehydes, amines and trimethylsilyl cyanide using a catalytic amount of mandelic acid as a naturally occurring, low-cost, efficient organo-catalyst under solvent-free conditions at room temperature. Under the same optimized conditions synthesis of α-aminophosphonates were also achieved via the one-pot three-component Kabachnik-Fields reactions of aldehydes, amines and triethyl phosphate.

Novel nano molten salt tetra-2,3-pyridiniumporphyrazinato-oxo-vanadium tricyanomethanide as a vanadium surface-free phthalocyanine catalyst: Application to Strecker synthesis of α-aminonitrile derivatives

Efficient and recyclable novel nano tetra-2,3-pyridiniumporphyrazinato-oxo-vanadium tricyanomethanide, {[VO(TPPA)][C(CN)3]4}, as a vanadium surface-free phthalocyanine-based molten salt catalyst was successfully designed, produced an

Dibutyltin dimethoxide-catalyzed cyano transfer to aldehydes and imines

A novel reaction involving cyano transfer from benzophenone cyanohydrin to aldehydes and imines was realized by using dibutyltin dimethoxide as a catalyst. Various cyanohydrins and α-amino nitriles were obtained in moderate to high yields by this reaction. Ketimines also showed remarkable reactivity as cyano acceptors under conventional reaction conditions. This catalytic reaction was further applied to a three-component condensation reaction of aldehydes, aniline, and benzophenone cyanohydrin in the presence of Drierite. Copyright

Dibutyltin dibromide-catalyzed trimethylsilylcyanation of aldehydes and imines

Dibutyltin dibromide efficiently catalyzes addition of tri-methylsilyl cyanide to aldehydes and aldimines. Various tri-methylsilylated cyanohydrins and α-aminonitriles are obtained in moderate to high yield by this method. Copyright