92990-44-8

Usage

Uses

Used in Pharmaceutical Industry:
2-Amino-1-pyridin-3-yl-ethanol is used as an intermediate in the synthesis of pharmaceuticals for its ability to be incorporated into the molecular structures of various drugs. Its unique chemical properties allow it to contribute to the development of new medications with specific therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical sector, 2-amino-1-pyridin-3-yl-ethanol serves as an intermediate in the production of agrochemicals, potentially enhancing the effectiveness of pesticides or other agricultural chemicals by integrating into their chemical compositions.
Used in Neurological Disorder Treatment:
2-Amino-1-pyridin-3-yl-ethanol is studied for its potential applications in the treatment of neurological disorders such as Parkinson's disease and Alzheimer's disease, due to its possible interaction with neurological pathways and mechanisms associated with these conditions.
Used in Antimicrobial Applications:
2-AMINO-1-PYRIDIN-3-YL-ETHANOL has been investigated for its antimicrobial properties, suggesting its use in applications that require the inhibition of microbial growth, which can be relevant in various industries including healthcare and food preservation.
Used in Drug Development:
2-Amino-1-pyridin-3-yl-ethanol is considered a potential building block for the development of new drugs owing to its unique structure, which can be leveraged to create novel therapeutic agents with specific targets and mechanisms of action.
Used in Drug Delivery Systems:
Its potential role in drug delivery systems is being explored to improve the efficacy and targeted delivery of pharmaceutical agents, possibly enhancing the therapeutic outcomes and reducing side effects.

InChI:InChI=1/C7H10N2O/c8-4-7(10)6-2-1-3-9-5-6/h1-3,5,7,10H,4,8H2

Upstream product

• 51746-82-8 2-amino-1-pyridin-3-yl-ethanone dihydrochloride salt 
• 500-22-1 3-pyridinecarboxaldehyde 
• 57402-97-8 N-<(trimethylsilyl)methyl>benzaldimine 
• 6221-12-1 3-Bromoacetylpyridine 
• 101861-30-7 rac-2-nitro-1-(pyridin-3-yl)ethan-1-ol 
• 800402-00-0 2-(2-oxo-2-pyridin-3-yl-ethyl)-isoindole-1,3-dione 
• 6283-81-4 3-oxo-3-pyridin-3-yl-propionic acid ethyl ester 
• 350-03-8 methyl-3-pyridylketone 
• 92639-84-4 2-hydroxyimino-1-(3-pyridyl)-1-ethanone 
• 61296-12-6 2-hydroxyimino-3-oxo-3-[3]pyridyl-propionic acid ethyl ester 

Relevant academic research and scientific papers

Novel amide- and sulfonamide-based aromatic ethanolamines: Effects of various substituents on the inhibition of acid and neutral ceramidases

In the present study we describe the design and synthesis of a series of amide- and sulfonamide-based compounds as inhibitor of recombinant acid and neutral ceramidases. Inhibition of ceramidases has been shown to induce apoptosis and to increase the efficacy of conventional chemotherapy in several cancer models. B-13, lead in vitro inhibitor of acid ceramidase has been recently shown to be virtually inactive towards lysosomal acid ceramidase in living cells at lower concentrations and for a shorter time of treatment, suggesting the development of more potent inhibitors. In this study, a detailed SAR investigation has been performed to understand the effect of different substituents on the phenyl ring of amide- and sulfonamide-based compounds that partially resemble the structure of well-known inhibitors such as B-13, D-e-MAPP as well as NOE. Our results suggest that the electronic effects of the substituents on phenyl ring in B-13 and D-e-MAPP analogues have negligible effects either in enhancing the inhibition potencies or for selectivity towards aCDase over nCDase. However, the hydrophobicity and the steric effects of longer alkyl chains (n-Pr, n-Bu or t-Bu groups) at the phenyl ring were found to be important for an enhanced selectivity towards aCDase over nCDase.

INDOLE-2-CARBOXYLIC ACID AMIDES

Compounds represented by Formula (I) or pharmaceutically acceptable salts thereof, are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or

PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDE INHIBITORS OF GLYCOGEN PHOSHORYLASE

Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.

Synthetic Versatility of N(Silylmethyl)imines: Water-Induced Generation of N-Protonated Azomethine Ylides of Nonstabilized Type and Fluoride-Induced Generation of 2-Azallyl Anions

N-(Silylmethyl)imines generate N-protonated azomethine ylides of nonstabilized type when treated with water in HMPA, which undergo stereospecific and regioselective cycloadditions with electron-poor olefins affording N-unsubstituted pyrrolidines.On the other hand, fluoride-induced desilylation of the imines leads to 2-azallyl anions which are found to be synthetic equivalents of aminomethyl anion in the Michael additions with electron-poor olefins and nucleophilic additions with carbonyl compounds.