5745-51-7

Basic information

• Product Name: 2,4,6-trimethylbenzoic anhydride
• CAS NO: 5745-51-7
• Molecular Formula: C₂₀H₂₂O₃
• Molecular Weight: 310.3869
• Mol File: 5745-51-7.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 472.6°C at 760 mmHg
• Flash Point: 224.9°C
• Density: 1.091g/cm³
• Vapor Pressure: 4.23E-09mmHg at 25°C
• Refractive Index: 1.559
• CAS DataBase Reference: 2,4,6-trimethylbenzoic anhydride(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,6-trimethylbenzoic anhydride(5745-51-7)
• EPA Substance Registry System: 2,4,6-trimethylbenzoic anhydride(5745-51-7)

Safety Data

• Hazardous Substances Data: 5745-51-7(Hazardous Substances Data)

Usage

General Description

2,4,6-trimethylbenzoic anhydride, also known as trimellitic anhydride, is a chemical compound with the molecular formula C9H6O3. It is a colorless to pale yellow solid that is used in the production of plasticizers, coatings, and as a crosslinking agent for epoxy resins. It is also a key intermediate in the synthesis of various organic compounds and pharmaceuticals. In addition, 2,4,6-trimethylbenzoic anhydride is known for its potential as a sensitizing agent and can cause skin and respiratory irritation in high concentrations. Therefore, proper safety precautions should be taken when handling this chemical.

Upstream product

• 58863-45-9 2,4,6-Trimethyldithiobenzoesaeure-methylester 
• 480-63-7 mesitylenecarboxylic acid 
• 78605-38-6 Diphenyl 2-oxo-3-oxazolinylphosphonate 
• 2904-57-6 mesitylenecarbonitrile oxide 
• 4028-63-1 iodomesitylene 
• 201230-82-2 carbon monoxide 
• 67-56-1 methanol 
• 65037-34-5 bis[(mesitylcarbonyl)oxy](phenyl)-λ³-iodane 
• 20434-88-2 3,5-dimesityl-1,2,4-oxadiazole-4-oxide 
• 111384-92-0 [carbonic acid-(1-methyl-heptyl ester)]-(2,4,6-trimethyl-benzoic acid )-anhydride 
• 938-18-1 mesitylene-2-carboxylic acid chloride 
• 501-53-1 benzyl chloroformate 
• 108881-54-5 (carbonic acid ethyl ester)-(2,4,6-trimethyl-benzoic acid )-anhydride 
• 110-86-1 pyridine 

Downstream Products

• 858491-23-3 2,4,6-trimethyl-benzoic acid-(2,6-dichloro-phenyl ester) 
• 60045-27-4 3-phenylpropionic acid 3-phenylpropyl ester 
• 5623-45-0 dimesityl ketone 
• 480-63-7 mesitylenecarboxylic acid 
• 4170-90-5 2,4,6-trimethylbenzyl alcohol 
• 121811-05-0 2,4,6-Trimethyl-benzoic acid 2-sulfamoyl-benzothiazol-6-yl ester 

Relevant articles and documents

Light-enabled synthesis of anhydrides and amides

Recently, we have demonstrated that the photogeneration of Vilsmeier-Haack reagents is possible using only dimethylformamide (DMF) and tetrabromomethane (CBr4) in the bromination of alcohols. Extending these findings to carboxylic acid substrates has produced a mild and facile approach to the in situ formation of symmetric anhydrides, which were conveniently converted to amide derivatives in a one-pot process. The efficient protocols discussed herein are marked by use of UVA LEDs (365 nm), which have reduced the reaction times and come with a low setup cost.

A Cheap, Simple and Efficient Method for the Preparation of Symmetrical Carboxylic Acid Anhydrides

A manipulatively simple and facile one-pot procedure for the synthesis of symmetrical anhydride is reported. Treatment of carboxylic acids with tosyl chloride in K2CO3 media under solvent free conditions gives the corresponding anhydrides in good to excellent yields in a short reaction time via carboxylic sulfonic anhydride as the key intermediate.

A thermal fragmentation of 1,2,4-oxadiazole-4-oxides to nitriles and nitrosocarbonyls

1,2,4-Oxadiazole-4-oxides undergo clean thermal cleavage in refluxing chlorobenzene or xylene to nitriles and nitrosocarbonyl intermediates, which are either trapped with suitable olefins to afford ene adducts or dimerize and rearrange to anhydrides. (C) 2000 Elsevier Science Ltd.