57641-21-1

Upstream product

• 622-04-8 1,3-diphenoxy-2-propanol 
• 66535-70-4 2-Trimethylsiloxy-1.3-diphenoxypropan 
• 36304-22-0 tert-butyl 2-phenoxyacetate 
• 701-99-5 Phenoxyacetyl chloride 
• 108-95-2 phenol 
• 816-39-7 1,3-dibromoroacetone 
• 119-36-8 methyl salicylate 

Downstream Products

• 1196475-97-4 C₂₇H₂₀BrNO₂S 
• 1196475-98-5 C₂₈H₂₄O₄S 
• 170124-05-7 4-(Butylthio)-1,3-diphenoxy-3-buten-2-one 
• 170124-04-6 4-(Dimethylamino)-1,3-diphenoxy-3-buten-2-one 

Relevant academic research and scientific papers

An economical noncatalytic approach to the synthesis of congested diaryl ethers and aryl benzyl thioethers through C-C insertion

An efficient one-pot synthesis of diaryl ethers and aryl benzyl thioethers has been delineated through base-induced ring transformation of 6-aryl-4-methylthio-2H-pyran-2-one-3-carbonitriles, methyl 6-aryl-4-methylthio- 2H-pyran-2-one-3-carboxylates and 6-aryl-4-(piperidin-1-yl)-2H-pyran-2-one-3- carbonitriles by either 1-phenoxypropan-2-one, 1,3-diphenoxypropan-2-one or 4-arylthiobutan-2-one, under very mild reaction conditions, in excellent yield. Georg Thieme Verlag Stuttgart.

Small molecule inhibitors of caspases

The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein A, B, D, E, G, J, n, and R1 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof as caspase inhibitors and for the treatment of disorders caused by excessive apoptotic activity.

CYSTEINE PROTEASE INHIBITORS EFFECTIVE FOR IN VIVO USE

A method of treating medical conditions with proteinase inhibitors of the formula: STR1 wherein B is H or an amino acid blocking group for the N-terminal amino acid nitrogen;R. sub.1 is an optionally protected α-amino acid side chain such that P. su

A novel reaction for the functionalization of epoxy resins: New regio- and chemoselective ring-opening of epoxides with aryl silyl ether catalyzed by cesium fluoride

By use of cesium fluoride as a catalyst, aryl or alkyl glycidyl ethers were ring-opened by aryl trimethylsilyl ether to produce O-protected aryloxyhydrins with a quantitative regioselectivity for the first time. Alkyl silyl ether was ineffective for this ring-opening.

Hypocholesterolemic activity of 1,3 bis(substituted phenoxy) 2 propanones

A series of 1,3 bis (substituted phenoxy) 2 propanones was found to be active hypocholesterolemic agents at 10 mg/kg/day. The p chloro and p methyl substituted phenoxy compounds possess the highest activity. These compounds did not possess the estrogenic and antifertility activities of the related previously reported derivatives of the bis (β phenylethyl) ketone series. The 1,3 bis (p methylphenoxy) 2 propanone (7) also lowered serum triglycerides and glycerol which appeared to be due to increased levels of serum lipase and reduced activity of liver lipase. There was reduced incorporation of free fatty acids into complex lipids by the liver. Cholesterol was excreted faster in the treated animals.