57774-72-8

Basic information

• Product Name: Carbamic acid, [(4-methoxyphenyl)thioxomethyl]-, ethyl ester
• CAS NO: 57774-72-8
• Molecular Formula: C11H13NO3S
• Molecular Weight: 239.295
• Mol File: 57774-72-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(4-methoxyphenyl)thioxomethyl]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(4-methoxyphenyl)thioxomethyl]-, ethyl ester(57774-72-8)
• EPA Substance Registry System: Carbamic acid, [(4-methoxyphenyl)thioxomethyl]-, ethyl ester(57774-72-8)

Safety Data

• Hazardous Substances Data: 57774-72-8(Hazardous Substances Data)

Upstream product

• 100-66-3 methoxybenzene 
• 16182-04-0 Ethoxycarbonyl isothiocyanate 

Downstream Products

• 82256-03-9 [1-(4-Methoxy-phenyl)-1-p-tolylamino-meth-(E)-ylidene]-carbamic acid ethyl ester 
• 1357927-42-4 ethyl (1-ethyl-1H-indolo-5-ylamino-4-methoxy-phenyl)methylenecarbamate 
• 1357927-47-9 7-ethyl-3-(4-methoxy-phenyl)-2,7-dihydro-1H-pyrrolo[3,2-f]quinazolin-1-one 
• 1036-50-6 8-methoxy-2-(4-methoxyphenyl)quinazolin-4-one 
• 82256-12-0 2-(4-Methoxyphenyl)-4(3H)-benzoquinazolinone 
• 82256-11-9 2-(4-methoxyphenyl)-6-methylquinazolin-4(3H)-one 
• 19407-61-5 6-chloro-2-(4-methoxyphenyl)-4(3H)-quinazolinone 
• 82256-04-0 [1-(4-Chloro-phenylamino)-1-(4-methoxy-phenyl)-meth-(E)-ylidene]-carbamic acid ethyl ester 
• 82266-83-9 2-(4-Methoxy-phenyl)-6,7-dihydro-thiazolo[3,2-a][1,3,5]triazin-4-one 
• 2519-93-9 2-(4-methoxyphenyl)-4,5-dihydro-1,3-thiazole 
• 6265-92-5 2-(4-methoxy-phenyl)-benzothiazole 
• 13676-94-3 2-(4-methoxyphenyl)-4,5-dihydrooxazole 
• 82256-02-8 [1-(4-Methoxy-phenyl)-1-phenylamino-meth-(E)-ylidene]-carbamic acid ethyl ester 
• 82256-05-1 N-Ethoxycarbonyl-N'-(2-naphthyl)-4-methoxybenzamidine 

Relevant articles and documents

Synthesis and evaluation of platelet aggregation inhibitory activity of some 3-phenyl-pyrroloquinazolinones

A series of 3-phenyl-2,7-dihydro-1H-pyrrolo[3,2-f]quinazolin-1-one derivatives (3-PPyQZ) was synthesized starting from 5-amino-indoles, via condensation with N-ethoxycarbonylthiobenzamides followed by thermal cyclization. On the basis of their structural analogy with reported anti-thrombin pyrroloquinazolines, the derivatives were first tested for their capacity to inhibit platelet aggregation. Some of them had in vitro inhibitory effects on collagen and thrombin-induced aggregation in the micromolar range, and much higher inhibition than that shown by some phenyl-pyrroloquinolinones. Experiments to determine the mechanism of action of the most potent inhibitor (compound 18) indicated that it acts in at least two sites: one preceding the agonist-induced increase of cytosolic [Ca2+], and one following this step of the platelet activation cascade. The compound also inhibited thrombin-evoked protein-Tyr-phosphorylation. Although it is premature to draw definitive conclusions, the present results indicate that 3-PPyQZ structure, with the quite potent inhibitor of platelet aggregation compound 18, might constitute a starting point for the synthesis of potential anti-thrombosis agents.