57777-78-3

Upstream product

• 67221-57-2 5'-O-(dimethoxytrityl)thymidine 3'-(p-chlorphenylcyanoethyl phosphate) 
• 69507-62-6 (p-chlorophenyl) (β-cyanoethyl) phosphorochloridate 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 13388-88-0 4-chlorophenyl phosphate 
• 106-48-9 4-chloro-phenol 
• 57777-76-1 O^5'-(4-methoxy-trityl)-[3']thymidylic acid mono-(2-chloro-phenyl) ester 
• 772-79-2 4-chlorophenylphosphorodichloridate 
• 32666-92-5 p-chlorophenyl phosphorodichloridite 
• 78272-46-5 p-chlorophenyl-bis-(β-cyanoethyl)-phosphite 
• 78272-47-6 p-chlorophenyl-bis-(β-cyanoethyl)-phosphate 
• 78272-50-1 p-chlorophenyl-β-cyanoethylphosphoric acid cyclohexylammonium salt 

Downstream Products

• 67221-73-2 N-benzoyl-5'-O-(bis(4-methoxyphenyl)phenylmethyl)-P-(4-chlorophenyl)-2'-deoxycytidylyl-(3'->5')-3'-thymidylic acid, 4-chlorophenyl 2-cyanoethyl ester 
• 67221-59-4 N-benzoyl-5'-O-(bis(4-methoxyphenyl)phenylmethyl)-P-(4-chlorophenyl)-2'-deoxyadenylyl-(3'->5')-3'-thymidylic acid, 4-chlorophenyl 2-cyanoethyl ester 
• 87324-60-5 C₆₁H₅₆Cl₂N₆O₁₆P₂ 
• 67221-67-4 C₄₁H₄₀Cl₂N₆O₁₅P₂ 

Relevant academic research and scientific papers

Synthesis of Deoxyoligonucleotide Linker Fragments for Genetic Engineering Using Improved Preparative and Analytical Techniques

For studies on the expression of recombinant DNA, linker fragments have been prepared which serve to introduce specific points of cleavage on the DNA as well as the protein level.Such linkers were designed for cyanogen bromide as well as for collagenase cleavage of fused proteins.The preparation was done according to the triester synthesis scheme using improved and simpler routes to functionalized dinucleotide building blocks.Field desorption mass spectrometry was used as a routine tool for the identification and control of the purity of these units.

NOUVELLE SYNTHESE SIMPLE DE DEOXYRIBONUCLEOSIDE-3'-ARYL-β-CYANOETHYL-PHOSPHATES

The deoxyribonucleoside-3'-aryl-β-cyanoethyl-phosphates, very used in the synthesis of oligodeoxynucleotides, were synthesized in high yields in a single step from the nucleoside derivatives with a monofunctional phosphorylating agent : cyclohexylammonium

A SIMPLIFIED STRATEGY FOR THE SYNTHESIS OF DIDEOXYRIBONUCLEOTIDE BLOCKS

The rapid synthesis of dideoxyribonucleotide blocks in 60-85percent isolated yields has been achieved by combining the phosphorylation and condensation steps in a sequential reaction series which also allows the recovery of unreacted nucleotides.