57792-17-3

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 54807-57-7 2-(bis(trimethylsilyl)amino)phenyl bromide 
• 132431-13-1 N-(2-bromophenyl)-O-benzyl carbamate 
• 1586-73-8 tris(trimethylsilyl)amine 
• 40949-94-8 potassium hexamethylsilazane 
• 108-95-2 phenol 
• 615-43-0 2-iodophenylamine 
• 993-07-7 trimethylsilan 
• 1066-54-2 trimethylsilylacetylene 
• 15290-22-9 o-(trimethylsilyl)nitrobenzene 

Downstream Products

• 1427772-65-3 4-dodecyloxy-3,5-bis(2-trimethylsilylphenyliminomethyl)phenylacetylene 
• 1449294-73-8 3-(2-(trimethylsilyl)phenyl)quinazoline-2,4(1H,3H)-dione 
• 18001-42-8 acetic acid-(2-trimethylsilanyl-anilide) 

Relevant academic research and scientific papers

Synthesis of 2,2′-Bis(silyl)azobenzenes by Oxidation of 2-(Silyl)anilines

A method was developed for the synthesis of 2,2′-bis(trimethylsilyl)- and 2,2′-bis(triethoxysilyl)-azobenzenes based on oxidation of 2-(silyl)anilines with trimethylamine and N-methylmorpholine oxides in the presence of CuX (X = Cl, Br).

One-Pot Generation of Benzynes from Phenols: Formation of Primary Anilines by the Deoxyamination of Phenols

Benzynes were selectively generated in situ from phenols and trapped regioselectively with potassium hexamethyldisilazide to form primary anilines following acidic workup. The direct conversion of a phenolic hydroxyl group into a free amino group is a useful method for the preparation of primary aryl amines that are hard to synthesize by using coupling reactions involving phenol derivatives with ammonia. Whereas reactions of ortho- and meta-substituted phenols produced meta-substituted anilines exclusively, those of para-substituted phenols provided ortho-silylanilines.

NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE INHIBITORS AND METHODS FOR USE OF THE SAME

Disclosed herein are compounds that can act as inhibitors of nicotinamide phosphoribosyltransferase ("NAMPT"), and methods for their use in treating or preventing diseases, such as pulmonary arterial hypertension ("PAH"). The compounds described herein ca

Living-like helix-sense-selective polymerization of an achiral substituted acetylene having bulky substituents

By using a new achiral phenylacetylene having bulky substituents as a monomer, living-like helix-sense-selective polymerization (HSSP) has been achieved. This is the first example of the HSSP of substituted acetylenes where the degree of polymerization was controlled. The resulting one-handed helical living polymer initiated polymerization of a second monomer to successfully yield a block copolymer.

Synthesis of N-and C-trimethylsilyl-substituded anililes

N-Metallation of bromoanilines with ethylmagnesium bromide followed by a reaction with trimethylchlorosilane provided N-mono and N-bis(trimethylsilyl) bromoanilines depending on the structure of substrate. The metallation of bissilylated bromoanilines with butyllithium permitted the introduction of a trimethylsilyl substituent in the aromatic ring. Previously unknown 2-bromo-N,N-bis(trimethylsilyl)aniline, 2,6-dibromo-N-trimethylsilylaniline, 2,6-dibromo-N,N-bis(trimethylsilyl)aniline, 2-bromo-6-trimethylsilylaniline, 2-bromo-6-trimethylsilyl-N,N-bis(trimethylsilyl)aniline, 2-bromo-6- trimethylsilyl-N-trimethylsilylaniline, 2,4,6-tribromo-N-trimethylsilylaniline, and 2,4,6-tribromo-N,N-bis(trimethylsilyl)aniline were prepared. The structures of the compounds obtained were established by the chromato-mass spectrometry and 1H, 13C, and 29Si NMR spectroscopy.

Compounds useful in therapy

There is provided a compound of formula I, wherein Het1, T, X, R1, R2and R3have meanings given in the description, which are useful in the prophylaxis and in the treatment of diseases mediated by opiate receptors, such as pruritus.