159334-03-9

Upstream product

• 38239-32-6 methyl 5-bromo-4-nitrothiophene-2-carboxylate 
• 100-67-4 potassium phenolate 
• 57800-76-7 5-chloro-4-nitrothiophene-2-carboxylic acid methyl ester 
• 108-95-2 phenol 
• 35475-03-7 methyl 5-chloro-2-thiophenecarboxylate 
• 24065-33-6 5-Chlorothiophene-2-carboxylic acid 
• 6310-09-4 2-acetyl-5-chlorothiophene 

Downstream Products

• 38239-39-3 4-nitro-5-piperidin-1-yl-thiophene-2-carboxylic acid methyl ester 
• 7274-00-2 aniline; compound with phenol 
• 78399-05-0 5-anilino-4-nitro-thiophene-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

BUMETANIDE DERIVATIVES FOR THE THERAPY OF HYPERHIDROSIS

The present invention relates to bumetanide derivatives of formula (I) as well as pharmaceutical compositions comprising these compounds for use in the treatment or prevention of diseases/disorders involving Na+- K+- 2CI- - cotransporters (NKCCs), and particularly for use in the treatment or prevention of hyperhidrosis.

Aromatic Nucleophilic Substitution Reactions of Some 2-L-3-Nitro-5-X-thiophenes with Piperidine and Aniline in Methanol. Substituent Constants for the Thiophene System

The rate constants for the reactions of some 2-L-3-nitro-5-X-thiophenes 1-4 with aniline and of compounds (4) with piperidine in methanol have been measured at various temperatures.By using the data obtained in this work as well as previously available data sets, a series of optimized 'thiophene' ?τ values has been calculated.The susceptibility constants ρ(L) of the various sets have been analysed in the framework of the reactivity-selectivity principle.