579-52-2

Usage

Uses

Used in Pharmaceutical Industry:
4-[hydroxy(phenyl)methyl]benzoic acid is used as an active pharmaceutical ingredient for the development of various medications. Its unique chemical structure and properties make it a valuable component in the formulation of drugs targeting specific health conditions.
Used in Organic Synthesis:
As an intermediate in organic synthesis, 4-[hydroxy(phenyl)methyl]benzoic acid is utilized in the production of complex organic compounds. Its reactivity and functional groups allow for the synthesis of a wide range of chemical entities, contributing to the advancement of chemical research and development.
Used in Antimicrobial Applications:
4-[hydroxy(phenyl)methyl]benzoic acid has been studied for its potential applications in the treatment of bacterial infections. Its antimicrobial properties make it a promising candidate for the development of new antibiotics or as a component in existing antimicrobial therapies.
Used in Antioxidant and Anti-inflammatory Research:
Scientific research has revealed that 4-[hydroxy(phenyl)methyl]benzoic acid possesses antioxidant and anti-inflammatory properties. These characteristics make it a valuable compound for the development of treatments and preventative measures for various diseases and conditions associated with oxidative stress and inflammation.

Upstream product

• 611-95-0 4-carboxybenzophenone 
• 79802-46-3 benzophenone-4-carboxylic acid radical anion 
• 128884-32-2 4-carboxybenzophenone ketyl 
• 65-85-0 benzoic acid 
• 586-76-5 4-Bromobenzoic acid 
• 100-52-7 benzaldehyde 
• 14047-29-1 4-carboxyphenylboronic acid 
• 1571-08-0 methyl 4-formylbenzoate 
• 100-59-4 phenylmagnesium chloride 
• 619-66-9 4-Carboxybenzaldehyde 
• 100-58-3 phenylmagnesium bromide 
• 108419-03-0 methyl 4-(hydroxyphenylmethyl)benzoate 
• 619-58-9 4-iodobenzoic acid 
• 6158-54-9 methyl 4-Benzoylbenzoate 

Downstream Products

• 108419-03-0 methyl 4-(hydroxyphenylmethyl)benzoate 
• 79631-37-1 4-Benzoylbenzoesaeure-pinacol 

Relevant academic research and scientific papers

Traceless directing group for stereospecific nickel-catalyzed alkyl-alkyl cross-coupling reactions

Stereospecific nickel-catalyzed cross-coupling reactions of benzylic 2-methoxyethyl ethers are reported for the preparation of enantioenriched 1,1-diarylethanes. The 2-methoxyethyl ether serves as a traceless directing group that accelerates cross-coupling. Chelation of magnesium ions is proposed to activate the benzylic C-O bond for oxidative addition.

Tuning the reducing properties of 1,2-diaryl-1,2-disodiumethanes

(Chemical Equation Presented) We investigated the reducing properties of a series of 1,2-diaryl-1,2-disodiumethanes by means of equilibration reactions. The electron-donor power of these vic-diorganometals is strongly affected by the nature of substituents present either on the aromatic ring(s) or on the carbanionic centers, and it can be correlated with their ability to delocalize the arylmethyl carbanions. These findings are supported by electrochemical analysis of the reduction behavior of the parent 1,2-diarylalkene. Applications of these results to the reduction of selected substrates are described. 2009 American Chemical Society.

Halogen-magnesium exchange on unprotected aromatic and heteroaromatic carboxylic acids

The magnesiation of halogenated aromatic and heteroaromatic carboxylic acids is accomplished by their treatment with MeMgCl in the presence of LiCl and subsequent reaction with i-PrMgCl·LiCl; the resulting double-magnesiated species react with a variety of electrophiles in up to 97% yield. The Royal Society of Chemistry.

t-Bu-Amphos-RhCl3·3H2O: A highly recyclable catalyst system for the cross-coupling of aldehydes and aryl- and alkenylboronic acids in aqueous solvents

The combination of t-Bu-Amphos and RhCl3·3H2O gave the first highly recyclable catalyst for the coupling of aryl- and vinylboronic acids with aldehydes in aqueous solvents. The Royal Society of Chemistry 2005.

Method for producing Grignard compounds

The invention relates to a process for preparing Grignard compounds of the formula I. The invention additionally relates to compounds of the formula I and to polymer-bound compounds of the formula Ia. The invention further relates to the use of the process for preparing substance libraries and to the use of the compounds of the formulae I and Ia in chemical synthesis.

METHOD OF SUBSTITUENT INTRODUCTION THROUGH HALOGEN-METAL EXCHANGE REACTION

A method of exchanging a halogen atom of a halide, which has a group containing an acidic proton and in which one or more halogen atom(s) is/are substituted on a carbon atom of the carbon-carbon double bond, with a metal atom by halogen-metal-exchange reaction and introducing an electrophilic reagent into the carbon atom to which the metal atom is attached. The above method is an industrially excellent method of introducing a substituent by halogen-metal exchange reaction.

CATHEPSIN CYSTEINE PROTEASE INHIBITORS

This invention relates to class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis. They have the following structure: Formula (I).

Non-cryogenic metalation of aryl bromides bearing proton donating groups: Formation of a stable magnesio-intermediate

Bromine-metal exchange of o-bromobenzoic acid (1) with Bu2Mg followed by n-BuLi was successfully carried out at non-cryogenic temperature (>-20°C), and gave a stabilized metal species which smoothly reacted with several electrophiles. This methodology expanded to several other bromides bearing proton donating groups (PDGs).

Synthesis of novel analogues of the delta opioid ligand SNC-80 using REM resin

Focused libraries of delta opioid ligands were synthesised using REM resin methodology. Several high affinity compounds were identified with good selectivity over the g opioid receptor. Automated REM resin recycling was used to synthesise larger amounts o

Synthesis of novel analogues of the delta opioid ligand SNC-80 using AlCl3-promoted aminolysis

Two focused libraries of delta opioid ligands were synthesised using AlCl3 facilitated aminolysis. Several compounds were identified with DOR binding affinities higher or similar to SNC-80. A novel acyclic derivative of SNC-80 produced antinoci