580-48-3

Usage

Uses

Used in Agricultural Industry:
2,4-DI-(N,N'-DIETHYLAMINO)-6-CHLOROTRIAZINE is used as a herbicide for controlling the growth of unwanted plants and weeds in various crops. Its application helps to improve crop yield by reducing competition for resources such as nutrients, water, and sunlight. 2,4-DI-(N,N'-DIETHYLAMINO)-6-CHLOROTRIAZINE's effectiveness in controlling a wide range of weeds makes it a popular choice among farmers and agricultural professionals.
In addition to its use as a herbicide, 2,4-DI-(N,N'-DIETHYLAMINO)-6-CHLOROTRIAZINE may also have potential applications in other industries due to its unique chemical properties. However, further research and development would be required to explore these possibilities and ensure the safety and efficacy of its use in different contexts.

InChI:InChI=1/C11H20ClN5/c1-5-16(6-2)10-13-9(12)14-11(15-10)17(7-3)8-4/h5-8H2,1-4H3

Upstream product

• 109-99-9 tetrahydrofuran 
• 108-77-0 1,3,5-trichloro-2,4,6-triazine 
• 109-89-7 diethylamine 
• 110-18-9 N,N,N,N,-tetramethylethylenediamine 
• 121-44-8 triethylamine 

Downstream Products

• 2827-49-8 N₂,N₂,N₄,N₄,N₆,N₆-hexaethyl-1,3,5-triazine-2,4,6-triamine 
• 13957-36-3 tetra-N-ethyl-6-hydrazino-[1,3,5]triazine-2,4-diamine 
• 4022-55-3 2-mercapto-4,6-bis(diethylamino)-symm-triazine 

Relevant academic research and scientific papers

Synthesis and spectral properties of triazine-based dendritic dithienylethenes

Two novel triazine-based dendrimers comprising a dithienylethene core and eight and 16 ethyl groups around the periphery were synthesised in high yields in a convergent way, without using tedious protection and chromato-graphic separation steps. Their optical properties such as photochromism, fluorescence emission and film-forming behaviour were investigated. The new symmetrical dendritic dithienylethenes showed typical photochromic behaviour in solution and good film-forming performance in a poly(methyl methacrylate) (PMMA) matrix. Moreover, the dendrimers have demonstrated remarkable fluorescence enhancement and good solubility in common organic solvents, compared with the corresponding small molecule diarylethene. Thus, the new dendrimers as optoelectronic materials, have potential applications in optical storage, photo-switches, and so on.

Synthesis of Amidation Agents and Their Reactivity in Condensation Reactions

Nowadays, the development of new approaches which smartly bypass the use of harsh reaction conditions and hazardous chemicals covers a pivotal role. In this research paper the synthesis, characterization, and application of novel libraries of triazine bis-quaternary ammonium salts, employed as coupling agents to produce amides is reported. Full characterization of the novel compounds by 1H and 13C NMR, FT-IR spectroscopy, ESI-HRMS, and elemental analysis is provided. Furthermore, a comparison in terms of activity of the preformed triazine compounds versus in situ formulations has been evaluated for the formation of amides in the presence of phenylethylamine and different aliphatic or aromatic acids. A possible correlation between the chemical structure of the triazine and their reactivity for the formation of the triazine bis-quaternary ammonium salts is also reported. Moreover, best performing condensation agents have been further tested for the cross-linking of collagen powder as possible wet white tanning systems, for sustainable and environmentally friendly leather tanning.

Design, synthesis, anticancer, antibacterial, and antifungal evaluation of 4-aminoquinoline-1,3,5-triazine derivatives

A series of 4-aminoquinoline 1,3,5-triazine derivatives were synthesized and evaluated for anticancer activity against cancer cell lines HeLa, MCF-7, HL-60, HepG2 where these derivatives exert significant anticancer activity. The molecules found nontoxic against MCF-12A. The molecules also showed potent inhibition of EGFR-TK as compared to eroltinib in enzyme-based assay. The newly synthesized derivatives were screened for their in vitro antibacterial and antifungal activity against Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, Proteus vulgaris, Escherichia coli, Pseudomonas aeruginosa and Candida albicans, Aspergillus niger, Aspergillus fumigatus using cefixime and fluconazole as standard. Antibacterial screening results suggest that compound 7c showed potent activity against S. aureus, P. aeruginosa, and P. vulgaris. In antifungal screening, compound 7b showed significant activity against A. niger, A. fumigatus and moderate activity against C. albicans.

Targeting the erythrocytic and liver stages of malaria parasites with s-triazine-based hybrids

A diversity-oriented library of s-triazine-based hybrids was screened for activity against the chloroquine-resistant Plasmodium falciparum W2 strain. The most striking result was sub-micromolar activity against cultured erythrocytic-stage parasites of hybrid molecules containing one or two 8-aminoquinoline moieties. These compounds were not clearly toxic to human cells. The most effective blood-schizontocidal s-triazine derivatives were then screened for activity against the liver stage of malaria parasites. The s-triazine hybrid containing two 8-aminoquinoline moieties and one chlorine atom emerged as the most potent against P. berghei liver-stage infection, active in the low nanomolar region, combined with good metabolic stability in rat liver microsomes. These results indicate that s-triazine-8-aminoquinoline-based hybrids are excellent starting points for lead optimization as dual-stage antimalarials.

Triazine-pyrimidine based molecular hybrids: Synthesis, docking studies and evaluation of antimalarial activity

A series of novel triazine-pyrimidine hybrids have been synthesized and evaluated for their in vitro antimalarial activity. Some of the compounds showed promising antimalarial activity against both CQ-sensitive and CQ-resistant strains at micromolar level with a high selectivity index. All the compounds displayed better activity (IC50 = 1.32-10.70 μM) than the standard drug pyrimethamine (>19 μM) against the chloroquine-resistant strain W2. All the tested compounds were nontoxic against mammalian cell lines. Further, docking studies of the most active compounds were performed on both wild type and quadruple mutant (N51I, C59R, S108N, I164L) PfDHFR-TS using Glide to analyse the interaction of the compounds with the binding site of the protein. The binding poses of compounds 14 and 19, having a high Glide XP score and the lowest Glide energies, show an efficient binding pattern similar to that of the DHFR substrate (dihydrofolate) in the wild type and mutant DHFR active site. The analysis of the pharmacokinetic properties of the most active compounds using ADMET prediction attests to the possibility of developing compound 14 as a potent antimalarial lead. This journal is

Discovery of ortho-carborane-conjugated triazines as selective topoisomerase I/II inhibitors

The cell growth inhibition profile of 2,4-(2-methyl-ortho-carboranyl)-4- (dimethylamino)-1,3,5-triazine (TAZ-6) was found to be similar to that of ICRF-193, a topoisomerase II inhibitor, as revealed by COMPARE analysis (correlation coefficient (r)≤0.724). Various mono-and di-ortho-carborane- substituted 1,3,5-triazines were synthesized based on the structure of TAZ-6 and tested for their ability to inhibit cell growth and the activities of topoisomerases I and II. Among the compounds synthesized, 3c, 4c, and 4f completely inhibited topoisomerase I activity without affecting topoisomerase II activity, whereas 3a and 3d completely inhibited topoisomerase II activity without affecting topoisomerase I activity, at 100μM.