58039-64-8 Usage
Description
2-[2-phenylethyl]-morpholine is an organic compound with the molecular formula C16H21NO. It is a derivative of morpholine, an ether-sulfide compound, featuring a phenylethyl group attached to the second carbon of the morpholine ring. This structural characteristic endows it with unique properties and potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
2-[2-phenylethyl]-morpholine is used as a key intermediate in the synthesis of various pharmaceutical compounds for its ability to form 2,4-disubstituted morpholines. These synthesized compounds are particularly effective in binding at human D4 dopamine receptors, which play a crucial role in the treatment of various central nervous system disorders, such as schizophrenia and other psychotic conditions.
The specific application of 2-[2-phenylethyl]-morpholine in the pharmaceutical industry lies in its utility as a building block for designing and developing novel drugs targeting the D4 receptor. By modulating the interactions at these receptors, the synthesized 2,4-disubstituted morpholines can potentially alleviate symptoms associated with the aforementioned disorders and contribute to the advancement of psychiatric therapeutics.
Check Digit Verification of cas no
The CAS Registry Mumber 58039-64-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,8,0,3 and 9 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 58039-64:
(7*5)+(6*8)+(5*0)+(4*3)+(3*9)+(2*6)+(1*4)=138
138 % 10 = 8
So 58039-64-8 is a valid CAS Registry Number.
58039-64-8Relevant articles and documents
A Concise Stereoselective Synthesis of (R)-2-Benzylmorpholine and ML398 from (R)-(?)-2-Phenylglycinol
Torres, Saúl,Velasco, Manuel,Gallegos-Rojas, José ángel,Bernès, Sylvain,Orea, María L.,Terán, Joel L.,Huelgas, Gabriela,Gómez-Calvario, Víctor,Juárez, Jorge R.
, p. 2677 - 2682 (2019/08/21)
We describe here an efficient stereoselective method for the preparation of (R)-2-benzylmorpholine and ML398. The present method features a high diastereocontrol using an endocyclic oxidation of phenylglycinol-derived morpholine and a stereoselective alky
A general, enantioselective synthesis of protected morpholines and piperazines
O'Reilly, Matthew C.,Lindsley, Craig W.
, p. 2910 - 2913 (2012/08/14)
A short, high yielding protocol has been developed for the enantioselective and general synthesis of C2-functionalized, benzyl protected morpholines and orthogonally N,N′-protected piperazines from a common intermediate.
MORPHOLINE DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS
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, (2008/06/13)
A class of substituted morpholine derivatives of formula STR1 wherein Y represents an optionally substituted bicyclic heteroaromatic ring system containing one or two nitrogen atoms, the ring system comprising a six-membered aromatic or heteroaromatic ring fused to a five-or six-membered heteroaromatic ring; and Z represents an optionally substituted arylalkyl, aryloxymethyl or arylalkoxymethyl group, are ligands for dopamine receptor subtypes within the body and are therefore useful in the treatment and/or prevention of disorders of the dopamine system, in particular schizophrenia.
