58058-86-9

Basic information

• Product Name: ethyl 2-(4-methylsulfonylphenyl)acetate
• Synonyms: ethyl 2-(4-methylsulfonylphenyl)acetate
• CAS NO: 58058-86-9
• Molecular Weight: 242.296
• Mol File: 58058-86-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: ethyl 2-(4-methylsulfonylphenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(4-methylsulfonylphenyl)acetate(58058-86-9)
• EPA Substance Registry System: ethyl 2-(4-methylsulfonylphenyl)acetate(58058-86-9)

Safety Data

• Hazardous Substances Data: 58058-86-9(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 90536-66-6 4-(methylsulfonyl)phenylacetic acid 
• 141-52-6 sodium ethanolate 
• 75-03-6 ethyl iodide 
• 5764-82-9 bromo(2-ethoxy-2-oxoethyl)zinc 
• 98-57-7 4-chlorophenyl methyl sulfone 

Downstream Products

• 1394240-76-6 3-[4-(methylsulfonyl)benzyl]-6-(biphenyl-4-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine 
• 1394240-77-7 6-(2,4-dichlorophenyl)-3-[4-(methylsulfonyl)benzyl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine 
• 1394240-75-5 6-(4-methylphenyl)-3-[4-(methylsulfonyl)benzyl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine 
• 940060-90-2 3-[4-(methylsulfonyl)benzyl]-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine 
• 428508-13-8 2-(4-(methylsulfonyl)phenyl)acetohydrazide 
• 1394240-82-4 C₂₅H₁₈Cl₂N₄O₂S₂ 
• 1394240-79-9 6-(2,5-dichloro-3-thienyl)-3-[4-(methylsulfonyl)benzyl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]-thiadiazine 
• 1394240-78-8 3-{3-[4-(methylsulfonyl)benzyl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl}-1H-isochromen-1-one 
• 1394240-81-3 2-hydroxy-5-{3-[4-(methylsulfonyl)benzyl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl}benzamide 
• 25025-07-4 (4-methanesulfonyl-phenyl)-acetonitrile 
• 374725-45-8 (4-methanesulfonyl-phenyl)-acetic acid amide 

Relevant articles and documents

Coupling of Reformatsky Reagents with Aryl Chlorides Enabled by Ylide-Functionalized Phosphine Ligands

The coupling of aryl chlorides with Reformatsky reagents is a desirable strategy for the construction of α-aryl esters but has so far been substantially limited in the substrate scope due to many challenges posed by various possible side reactions. This limitation has now been overcome by the tailoring of ylide-functionalized phosphines to fit the requirements of Negishi couplings. Record-setting activities were achieved in palladium-catalyzed arylations of organozinc reagents with aryl electrophiles using a cyclohexyl-YPhos ligand bearing an ortho-tolyl-substituent in the backbone. This highly electron-rich, bulky ligand enables the use of aryl chlorides in room temperature couplings of Reformatsky reagents. The reaction scope covers diversely functionalized arylacetic and arylpropionic acid derivatives. Aryl bromides and chlorides can be converted selectively over triflate electrophiles, which permits consecutive coupling strategies.

New 3- and 4-hydroxyfuranones as anti-oxidants and anti-inflammatory agents

Two series of new furanones substituted by methylsulfonylphenyl or methylsulfamidophenyl moieties were found to protect against oxidation damage by inhibiting or quenching free radicals and reactive oxygen species in in vitro experiments. The effect on lipid peroxidation was also examined. In addition, we investigated the activity of products in two models of inflammation: phorbol ester-induced ear edema in mice and carrageenan-induced paw edema in rat. The most powerful compounds and with reducing activity against DPPH (IC50 = 1779 and 57 μM, respectively), superoxide anion quenching capacity (IC50 = 511 and 49 μM, respectively), lipid peroxidation inhibitory effect and anti-inflammatory properties (about 50-65% inhibition of edema at 200 mg/kg ip in both tests used) were selected for further pharmacological and toxicological tests because of their attractive profile for the treatment of inflammatory diseases.

TRI(CYCLO) SUBSTITUTED AMIDE COMPOUNDS

Compounds of Formula (I): or pharmaceutically acceptable salts thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.