58349-01-2

Basic information

• Product Name: 4-BROMO-2-CHLORO-6-NITROPHENOL
• Synonyms: 4-BROMO-2-CHLORO-6-NITROPHENOL
• CAS NO: 58349-01-2
• Molecular Formula: C₆H₃BrClNO₃
• Molecular Weight: 252.45
• Mol File: 58349-01-2.mol

Chemical Properties

• Boiling Point: 257 °C at 760 mmHg
• Flash Point: 109.2 °C
• Appearance: /
• Density: 1.974 g/cm³
• Vapor Pressure: 0.00929mmHg at 25°C
• Refractive Index: 1.661
• CAS DataBase Reference: 4-BROMO-2-CHLORO-6-NITROPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2-CHLORO-6-NITROPHENOL(58349-01-2)
• EPA Substance Registry System: 4-BROMO-2-CHLORO-6-NITROPHENOL(58349-01-2)

Safety Data

• Hazardous Substances Data: 58349-01-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-BROMO-2-CHLORO-6-NITROPHENOL is used as an intermediate in the synthesis of pharmaceuticals for its potential anti-bacterial and anti-fungal properties, making it useful in the development of treatments for microbial infections.
Used in Agrochemical Industry:
4-BROMO-2-CHLORO-6-NITROPHENOL is used as an intermediate in the synthesis of agrochemicals, specifically in the production of insecticides and herbicides, due to its potential to control pests and weeds in agricultural settings.
Used in Dye and Pigment Industry:
4-BROMO-2-CHLORO-6-NITROPHENOL is used in the preparation of dyes and pigments, leveraging its chemical structure to create a range of colors for various applications.

InChI:InChI=1/C6H3BrClNO3/c7-3-1-4(8)6(10)5(2-3)9(11)12/h1-2,10H

Upstream product

• 4526-56-1 2,4-dibromo-6-chlorophenol 
• 64-19-7 acetic acid 
• 95-57-8 2-monochlorophenol 
• 50638-47-6 4-bromo-2-chloro-1-methoxybenzene 
• 603-86-1 2-chloro-6-nitrophenol 
• 7693-52-9 4-bromo-2-nitrophenol 
• 3964-56-5 4-bromo-2-chlorophenol 
• 7697-37-2 nitric acid 

Downstream Products

• 946-31-6 2-chloro-4,6-dinitro-phenol 
• 46008-81-5 tribromo-chloro-[1,4]benzoquinone 
• 20294-55-7 2-bromo-6-chloro-4-nitrophenol 
• 943994-32-9 methyl 2-(4-bromo-2-chloro-6-nitrophenoxy)acetate 
• 1426321-16-5 N-(5-bromo-3-chloro-2-hydroxyphenyl)cyclopropanecarboxamide 
• 1438262-45-3 4-bromo-2-chloro-6-cyclopropaneamidophenyl cyclopropanecarboxylate 
• 1226018-90-1 C₁₀H₇BrClNO 

Relevant articles and documents

CYCLOPROPYLDERIVATIVES AND THEIR USE AS KINASE INHIBITORS

The invention generally relates to cyclic compounds and, more particularly, to a compound represented by Structural Formula I: or a pharmaceutically acceptable salt thereof and pharmaceutical comopositions comprising the multicyclic compounds. The invention also relates to a method for treating a disease or disorder selected from cancer (e.g., lymphoma, such as mantle cell lymphoma), a neurodegenerative disease, an inflammatory diseases or an immune system disease (e.g., a T-Cell mediated autoimmune disesase) in a subject in need thereof. The method comprises administering to a subject in need thereof a therapeutically effective amount of a compound of the invention, or a pharmaceutically acceptable salt thereof, or a composition comprising a compound of the invention, or a pharmaceutically acceptable salt thereof.

Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors

The present disclosure relates to certain (2S)—N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

The synthesis of 1,2-ethanediylbis(triphenylphosphonium) ditribromide as a new brominating agent in the presence of solvents and under solvent-free conditions

Abstract: 1,2-Ethanediylbis(triphenylphosphonium) ditribromide was quantitatively prepared and used for the bromination of anilines and phenols in the presence of a mixed solvent system (DCM/MeOH 2:1) and also under solvent-free conditions. This new ionic liquid has advantages over similar brominating agents in terms of short reaction time, simple workup, regioselectivity and high yields. Single-crystal X-ray analysis of title salt revealed that the bistriphenylphosphonium cation is organized around an inversion center located at the center of the –CH2–CH2– bridge and the two triphenylphosphine segments are anti with respect to one another. All the tribromide anions adopt a linear geometry with different Br–Br–Br bond angles for each anion. Graphical Abstract: [Figure not available: see fulltext.]

CERTAIN (2S)-N-[(1S)-1-CYANO-2-PHENYLETHYL]-1,4-OXAZEPANE-2-CARBOXAMIDES AS DIPEPTIDYL PEPTIDASE 1 INHIBITORS

The present disclosure relates to certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF

Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and diso

FUSED HETEROCYCLIC COMPOUND AND USE THEREOF

The present invention relates to wherein each symbol is as defined in the specification. The compound has a superior mineral corticoidreceptorantagonistic action and is useful as an agent for the prophylaxis or treatment of hypertension, cardiac failure and the like, a compound having a fused heterocycle, or a prodrug thereof, or a salt thereof; and an agent for the prophylaxis or treatment of hypertension, cardiac failure and the like.

A convenient and regioselective oxidative bromination of electron-rich aromatic rings using potassium bromide and benzyltriphenylphosphonium peroxymonosulfate under nearly neutral reaction conditions

Regioselective oxidative bromination of electron-rich aromatic rings has been studied using potassium bromide as a bromine source in the presence of benzyltriphenylphosphonium peroxymonosulfate as oxidant under nearly neutral reaction conditions. In most cases we obtained monobrominated derivatives regioselectively and in good to high yields without the aid of strong acids.

1-Benzyl-4-aza-1-azoniabicyclo[2.2.2]octane tribromide as a regenerable and useful reagent for bromination of phenols under mild conditions

1-Benzyl-4-aza-1-azoniabicyclo[2.2.2]octane tribromide has been examined over several phenolic compounds under mild conditions. The reaction gives brominated phenols in good to excellent yields. Straightforward work-up of the reaction yields pure products in several cases.

A controlled and selective bromination of phenols by benzyltriphenylphosphonium tribromide

Reactions of phenols with benzyltriphenylphosphonium tribromide in dichloromethane-methanol mixture (2:1) gave mono, di and tri brominated phenols at room temperature with high selectivity and good yields.