58371-98-5

Basic information

• Product Name: 3,5-dichloropentan-2-one
• Synonyms: 3,5-dichloropentan-2-one;2-Pentanone, 3,5-dichloro-;3,5-Dichloro-2-pentanone;Einecs 261-227-0
• CAS NO: 58371-98-5
• Molecular Formula: C₅H₈Cl₂O
• Molecular Weight: 155.02242
• EINECS: 261-227-0
• Mol File: 58371-98-5.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 214.98°C (rough estimate)
• Flash Point: 82.3 °C
• Appearance: /
• Density: 1.2390
• Vapor Pressure: 0.217mmHg at 25°C
• Refractive Index: 1.4632 (estimate)
• CAS DataBase Reference: 3,5-dichloropentan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-dichloropentan-2-one(58371-98-5)
• EPA Substance Registry System: 3,5-dichloropentan-2-one(58371-98-5)

Safety Data

• Hazardous Substances Data: 58371-98-5(Hazardous Substances Data)

Usage

General Description

3,5-Dichloropentan-2-one is a chemical substance with the molecular formula C5H8Cl2O. This chemical belongs to the category of organochlorine compounds, specifically those containing a ketone group attached to an aliphatic chain. The ketone functional group (carbon-oxygen double bond) in the 2nd position and the chlorine atoms attached at the 3rd and 5th position of the carbon chain distinguish its structure. Typically, this chemical is used in the field of applied chemistry and research as it forms an integral part of various organic synthesis processes. Its physical, chemical, toxicological properties, as well as its handling and storage information may vary, so it needs to be used, stored, and disposed of with utmost care following guidelines. In addition, more detailed study is needed to understand the full extent of its impact on health and the environment.

InChI:InChI=1/C5H8Cl2O/c1-4(8)5(7)2-3-6/h5H,2-3H2,1H3

Upstream product

• 54527-68-3 2-chloroethyl acetoacetate 
• 517-23-7 3-acetyl-2-oxo-4,5-dihydrofuran 
• 141-97-9 ethyl acetoacetate 
• 107-06-2 1,2-dichloro-ethane 
• 75-09-2 dichloromethane 
• 78-94-4 methyl vinyl ketone 
• 5891-21-4 5-chloro-2-pentanone 
• 13045-13-1 3-chloro-3-acetylpropanol 
• 75-36-5 acetyl chloride 
• 2986-00-7 3-acetyl-3-chlorodihydrofuran-2(3H)-one 

Downstream Products

• 63141-09-3 1-chlorocyclopropyl methyl ketone 
• 120983-72-4 1-chlorocyclopropyl-2-chloro-ethan-1-one 
• 31299-91-9 2-chloro-5-(2-chloro-ethyl)-4-methyl-thiazole 
• 14066-76-3 4-methyl-5-(β-acetoxyethyl)-2-thiazolinethione 
• 5706-49-0 2-<1-Hydroxy-aethyl>-thiacyclobutan 
• 533-45-9 chlormethiazole 
• 5891-21-4 5-chloro-2-pentanone 
• 765-43-5 Cyclopropyl methyl ketone 
• 13051-49-5 5-Acetoxy-3-chloropentan-2-one 
• 7275-24-3 3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-chloro-ethyl)-4-methyl-thiazolium; chloride-hydrochloride 

Relevant articles and documents

Synthesis method for preparing 3,5-dichloro-2-pentanone from methyl acetoacetate

The invention discloses a synthesis method for preparing 3,5-dichloro-2-pentanone from methyl acetoacetate. The method comprises the following steps: S1: reactor preparation: preparing two reactors, namely a first reactor and a second reactor; S2, reactor cleaning: putting the first reactor and the second reactor into clear water for cleaning, flushing the first reactor and the second reactor after cleaning is completed, and drying the first reactor and the second reactor after flushing is completed; and S3, hydrolysis for salt formation: adding methyl acetoacetate into the first reactor, dropwise adding 30% caustic soda liquid under cooling of circulating water, and continuing to conducting a reaction for 6 hours after dropwise adding so as to obtain a hydrolyzed material. According to the synthesis method for preparing 3,5-dichloro-2-pentanone from methyl acetoacetate, working steps are rigorous, flammable and explosive materials are prevented from being used, safety is improved, reaction operations are reduced, reaction efficiency is improved, and cost is effectively reduced.

3,5-dichloro-2-pentanone preparation method

The invention relates to the field of fine chemicals, and discloses a 3,5-dichloro-2-pentanone preparation method, which comprises: making alpha-acetyl-gamma-butyrolactone contact sulfonyl chloride ina solvent-free system to carry out a chlorination reaction, mixing the material obtained by the chlorination reaction with water, adding hydrochloric acid to the obtained mixture in a dropwise manner, and carrying out a ring-opening reaction. According to the present invention, the solvent-free one-pot reaction is achieved by using the cheap industrial chemicals as the raw materials, such that the process operation is simplified, the three-waste and the production cost are reduced, and the pollution caused by the use of the metal catalyst is avoided.

Synthetic method of midbody 3,5-dichloro-2-pentanone

The invention discloses a synthetic method of midoby 3,5-dichloro-2-pentanone. The synthetic method adopts alpha-acetyl-gamma-butyrolactone, anhydrous potassium carbonate, alpha-acetyl-alpha-chloro-gamma-butyrolactone, hydrochloric acid, glacial acetic acid, Cu2O, benzidine and anhydrous THF as main raw materials, adopts alpha-acetyl-gamma-butyrolactone to be converted to the corresponding enol structure under the catalytic effect of the lewis acid-sulfonyl chloride, the chloride ions attach the alpha site of carbonyl, then protons are transferred, hydrogen protons are removed from a hydrogengroup, and then the hydrogen protons are re-arranged and converted to the carbonyl with more stable structure. When the acetic acid is used as a solvent and has certain solubility for an organic phaseand the hydrochloric acid, the reaction is easier, the reaction yield is greatly increased under the effect of a catalyst, the production process of prothioconazole is shortened, and the energy consumption is reduced.