5840-76-6

Basic information

• Product Name: 3-Methyl-2,5-oxazolidinedione
• Synonyms: 3-Methyl-2,5-oxazolidinedione;3-methyl-1,3-oxazolidine-2,5-dione
• CAS NO: 5840-76-6
• Molecular Formula: C₄H₅NO₃
• Molecular Weight: 115.0874
• Product Categories: Miscellaneous Reagents
• Mol File: 5840-76-6.mol
• Article Data: 23

Chemical Properties

• Melting Point: 99-100 °C
• Boiling Point: 138.7°C at 760 mmHg
• Flash Point: 37.7°C
• Appearance: /
• Density: 1.373g/cm³
• Vapor Pressure: 6.66mmHg at 25°C
• Refractive Index: 1.483
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: DMSO (Slightly)
• PKA: -2.08±0.20(Predicted)
• CAS DataBase Reference: 3-Methyl-2,5-oxazolidinedione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Methyl-2,5-oxazolidinedione(5840-76-6)
• EPA Substance Registry System: 3-Methyl-2,5-oxazolidinedione(5840-76-6)

Safety Data

• Hazardous Substances Data: 5840-76-6(Hazardous Substances Data)

Usage

Uses

3-Methyl-2,5-oxazolidinedione is used in the preparation of amphiphilic polypeptoids.

InChI:InChI=1/C4H5NO3/c1-5-2-3(6)8-4(5)7/h2H2,1H3

Upstream product

• 75-44-5 phosgene 
• 107-97-1 sarcosine 
• 39608-31-6 N-(Benzyloxycarbonyl)sarcosine 
• 13734-36-6 N-(tert-butoxycarbonyl)sarcosine 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 67-66-3 chloroform 
• 4316-73-8 sodium sarcosinate 
• 503-38-8 trichloromethyl chloroformate 
• 541-41-3 chloroformic acid ethyl ester 
• 116714-27-3 N-methoxycarbonyl-N-methyl-glycine 

Downstream Products

• 5076-82-4 sarcosine anhydride 
• 107-97-1 sarcosine 
• 74963-37-4 N-benzyl-2-(methylamino)acetamide 
• 1857-20-1 sarcosine dimethylamide 
• 35534-19-1 2-(methylamino)-1-phenylethan-1-one 

Relevant articles and documents

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Mapping the supramolecular assembly space of poly(sarcosine)-: B-poly(propylene sulfide) using a combinatorial copolymer library

A combinatorial copolymer library was created to rapidly screen the landscape of self-assembled nanostructure morphologies formed by block copolymers composed of hydrophilic peptoid polysarcosine (PSarc) and hydrophobic poly(propylene sulfide) (PPS) block

Cyclic Poly(α-peptoid)s by Lithium bis(trimethylsilyl)amide (LiHMDS)-Mediated Ring-Expansion Polymerization: Simple Access to Bioactive Backbones

Cyclic polymers display unique physicochemical and biological properties. However, their development is often limited by their challenging preparation. In this work, we present a simple route to cyclic poly(α-peptoids) from N-alkylated-N-carboxyanhydrides (NNCA) using LiHMDS promoted ring-expansion polymerization (REP) in DMF. This new method allows the unprecedented use of lysine-like monomers in REP to design bioactive macrocycles bearing pharmaceutical potential against Clostridioides difficile, a bacterium responsible for nosocomial infections.

Superfast and Water-Insensitive Polymerization on α-Amino Acid N-Carboxyanhydrides to Prepare Polypeptides Using Tetraalkylammonium Carboxylate as the Initiator

We design the tetraalkylammonium carboxylate-initiated superfast polymerization on α-amino acid N-carboxyanhydrides (NCA) for efficient synthesis of polypeptides. Carboxylates, as a new class of initiator for NCA polymerization, can initiate the superfast NCA polymerization without the need of extra catalysts and the polymerization can be operated in open vessels at ambient condition without the use of glove box. Tetraalkylammonium carboxylate-initiated polymerization on NCA easily affords block copolymers with at least 15 blocks. Moreover, this method avoids tedious purification steps and enables direct polymerization on crude NCAs in aqueous environments to prepare polypeptides and one-pot synthesis of polypeptide nanoparticles. These advantages and the mild polymerization condition of tetraalkylammonium carboxylate-initiated NCA polymerization imply its great potential in functional exploration and application of polypeptides.

METHOD FOR PRODUCING AMINO ACID-N-CARBOXYLIC ACID ANHYDRIDE

PROBLEM TO BE SOLVED: To provide: a method for safely and efficiently producing amino acid-N-carboxylic acid anhydride; and a method for producing peptide by using the obtained amino acid-N-carboxylic acid anhydride. SOLUTION: The method for producing an amino acid-N-carboxylic acid anhydride according to the present invention is characterized in that the amino acid-N-carboxylic acid anhydride is represented by the following formula (II), and a step of irradiating a composition containing a halogenated methane and an amino acid compound represented by the following formula (I) with high energy light in the presence of oxygen is included. [In the formula, R1 represents an amino acid side chain group in which the reactive group is protected, and R2 represents H or the like.]. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT