58598-96-2

Basic information

• Product Name: Pyridine, 2-(3-phenyl-1,2,4-oxadiazol-5-yl)-
• CAS NO: 58598-96-2
• Molecular Formula: C13H9N3O
• Molecular Weight: 223.234
• Mol File: 58598-96-2.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Pyridine, 2-(3-phenyl-1,2,4-oxadiazol-5-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 2-(3-phenyl-1,2,4-oxadiazol-5-yl)-(58598-96-2)
• EPA Substance Registry System: Pyridine, 2-(3-phenyl-1,2,4-oxadiazol-5-yl)-(58598-96-2)

Safety Data

• Hazardous Substances Data: 58598-96-2(Hazardous Substances Data)

Upstream product

• 100-70-9 2-Cyanopyridine 
• 873-67-6 benzonitrile oxide 
• 100-69-6 2-vinylpyridine 
• 613-92-3 N-hydroxybenzenecarboximidamide 
• 3731-51-9 2-(Aminomethyl)pyridine 
• 100-52-7 benzaldehyde 
• 1121-60-4 pyridine-2-carbaldehyde 
• 100-47-0 benzonitrile 
• 932-90-1 Benzaldoxime 
• 1772-01-6 2-pyridylamidoxime 
• 698-16-8 benzohydroximoyl chloride 
• 1448510-47-1 3-phenyl-5-(2-pyridyl)-1,2,4-oxadiazole-4-oxide 

Relevant articles and documents

TBAI/TBHP-Catalyzed Synthesis of [1,2,4]Triazolo[4,3-a]pyridines and 3,5-Diaryl-1,2,4-oxadiazoles via Oxidative Cleavage of C=C Double Bond

Abstract: A simple and efficient protocol has been described for the synthesis of [1,2,4]triazolo[4,3-a]pyri-dines and 3,5-disubstituted-1,2,4-oxadiazoles by reacting 2-hydrazinylpyridine and benzamidoximes, respec-tively, with styrenes via TBAI/TBHP-mediated oxidative cleavage of C=C bond under ligand- and metal-free conditions.

Copper-Catalyzed Three-Component Cascade Reaction of Benzaldehyde with Benzylamine and Hydroxylamine or Aniline: Synthesis of 1,2,4-Oxadiazoles and Quinazolines

The analogous three-component synthesis strategy for substituted 1,2,4-oxadiazole and quinazoline derivatives from readily available benzaldehyde, benzylamine and hydroxylamine or aniline has been developed. Both the cascade reaction sequences involves nucleophilic addition of C?N bond, introduction a halogen donor, nucleophilic substitution and Cu(II)-catalyzed aerobic oxidation. This synthesis methodology demonstrated good yields, broad substrate scope and oxygen as a green oxidant. Thus, this synthesis protocol provides strategies for the construction of substituted 1,2,4-oxadiazole and quinazolines from readily and simple starting materials. (Figure presented.).

Facile room-temperature assembly of the 1,2,4-oxadiazole core from readily available amidoximes and carboxylic acids

A one-pot ambient-temperature procedure for the synthesis of 3,5-disubstituted-1,2,4-oxadiazoles from amidoximes and carboxylic acids under superbase-promoted conditions is reported.