58743-75-2Relevant articles and documents
Preparation and characterization of Cu based on 2-(5-Aminopyrimidin-2-yl)pyrimidin-5-amine as novel recyclable metal–organic frameworks for Suzuki reaction
Mohammadnia, Majid
, (2021/11/24)
For first time, in this work, a new, heterogeneous and recyclable catalyst was designed using immobilizing Cu on 2-(5-Aminopyrimidin-2-yl)pyrimidin-5-amine ([CuAPPA·2H2O]n) named metal–organic frameworks (MOFs). This catalyst was used for the synthesis of biaryl derivatives by Suzuki reaction. Suzuki reaction performed with mixing of the aryl halides with arylboronic acids in the DMF solvent conditions. Also, the prepared catalyst was characterized with different analytical techniques such as FT-IR, XRD, SEM, EDX, BET and ICP-AES analysis. [CuAPPA·2H2O]n catalyst displayed good to excellent yields catalytic efficiency for Suzuki reaction in comparison with to other catalysts. Also, the recoverability and reusability related to this catalyst was checked by a simple filtration with reserving its activity even after several cycles.
Method for synthesizing biphenyl compound by taking phenol as raw material
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Paragraph 0071-0073, (2020/07/15)
The invention discloses a method for synthesizing a biphenyl compound by using phenol as a raw material in the technical field of organic chemical synthesis, which comprises the following steps: carrying out a mixed reaction process on phenol or substituted phenol, alkali and 50-90% ethanol aqueous solution, slowly introducing sulfonyl fluoride gas, and carrying out magnetic stirring reaction at normal temperature for 4-12 hours, adding arylboronic acid, alkali and a palladium catalyst into a round-bottom flask, continuing to react for 6-12 hours at normal temperature, after the reaction is finished, adding a saturated edible salt solution into the round-bottom flask, carrying out a water quenching reaction process to obtain a reaction mixture, extracting a reaction product from the reaction mixture by using ethyl acetate, combining organic phases, concentrating filtrate, and separating the concentrated filtrate by using column chromatography to obtain analytically pure biphenyl or terphenyl compounds. By using the method, on one hand, the production cost of the biphenyl compound is reduced, and on the other hand, the method also has a wide application prospect in the aspects of synthesis of natural products, medicines, pesticides, herbicides, polymer conduction materials, liquid crystal materials and the like.
Method for synthesizing biphenyl compound by taking suaeda salsa extract liquor as solvent
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Paragraph 0051-0052, (2020/06/30)
The invention discloses a method for synthesizing a biphenyl compound by using suaeda salsa extract as a solvent in the technical field of organic chemical synthesis, which comprises the following steps: roasting suaeda salsa in a muffle furnace to obtain ash, dissolving the ash in distilled water, refluxing, cooling the solution, and filtering to obtain a faint yellow solution which is the suaedasalsa extract liquor; sequentially adding 1mmol of aryl halide, 1.1mmol of arylboronic acid, 0.001mmol to 0.01mmol of a catalyst and 4ml of the suaeda salsa extract liquor into a round-bottom flask,stirring at 100 DEG C to react for 2 hours, cooling the reactant to room temperature, filtering, mixing the obtained filter residue with a palladium catalyst to obtain a mixture; and dissolving the mixture in ethyl acetate, filtering to remove the palladium catalyst, and drying the filtrate by distillation to obtain the biphenyl compound. According to the scheme, a phosphine ligand, alkali and anadditive do not need to be added, a Suzuki reaction system with biomass extract as a reaction medium is adopted, and a green, simple, convenient and efficient method is provided for synthesizing biphenyl compounds.
