5875-24-1

Basic information

• Product Name: 3-CHLOROPROPIONAMIDE
• Synonyms: Propanamide, 3-chloro-;3-CHLOROPROPANAMIDE;3-CHLOROPROPIONAMIDE;3-CHLOROPROPIONAMIDE 98%
• CAS NO: 5875-24-1
• Molecular Formula: C3H6ClNO
• Molecular Weight: 107.54
• EINECS: 227-542-2
• Product Categories: Amides;Carbonyl Compounds;Organic Building Blocks;Building Blocks;C2 to C7;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
• Mol File: 5875-24-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 98-101 °C(lit.)
• Boiling Point: 286.2 °C at 760 mmHg
• Flash Point: 126.9 °C
• Appearance: /
• Density: 1.191 g/cm³
• Vapor Pressure: 0.00268mmHg at 25°C
• Refractive Index: 1.452
• PKA: 15.92±0.40(Predicted)
• CAS DataBase Reference: 3-CHLOROPROPIONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLOROPROPIONAMIDE(5875-24-1)
• EPA Substance Registry System: 3-CHLOROPROPIONAMIDE(5875-24-1)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• Hazardous Substances Data: 5875-24-1(Hazardous Substances Data)

Usage

Uses

3-Chloropropionamide was used as alkylating agent in the synthesis of 1-(2-carbamoyl-ethyl)indole-3-acetic acid.

Synthesis Reference(s)

Synthetic Communications, 22, p. 3137, 1992 DOI: 10.1080/00397919209409264

InChI:InChI=1/C3H6ClNO/c4-2-1-3(5)6/h1-2H2,(H2,5,6)

Upstream product

• 7647-01-0 hydrogenchloride 
• 7732-18-5 water 
• 107-13-1 acrylonitrile 
• 79-06-1 2-propenamide 
• 52176-00-8 3,N-Dichlorpropionamid 
• 110-83-8 cyclohexene 
• 120158-04-5 t-butyl beta-chloropropionylcarbamate 
• 542-76-7 3-Chloropropionitrile 
• 625-36-5 2-chloropropionyl chloride 
• 84762-89-0 3-chloropropionimidic acid methyl ester 
• 21367-88-4 Methyl 3-chloropropionimidate hydrochloride 

Downstream Products

• 60246-97-1 3-(4,5-diphenyl-oxazol-2-ylsulfanyl)-propionamide 
• 61892-68-0 3-cyanopropionamide 
• 112394-67-9 3-(3-Phenyl-thiazolo[5,4-e][1,2,4]triazin-6-ylsulfanyl)-propionamide 
• 6320-96-3 3-bromopropanamide 
• 90562-46-2 3-[(4-chlorophenyl)thio]propanamide 
• 609811-08-7 N-(1-benzenesulfonyl-3-phenyl-propyl)-3-chloro-propionamide 
• 1359073-27-0 C₁₆H₂₁N₃O₄ 

Relevant articles and documents

Sonochemically induced reaction between water and 3-chloropropionitrile

The water-3-chloropropionitrile biphasic system reacts in an ultrasonic bath, producing the corresponding amide, at room temperature. The C-Cl bond does not react; in this sense the attack is selective.

Nitrile biotransformation by whole cells of Aspergillus sp. PTCC 5266

Aspergillus sp. PTCC 5266 exhibited nitrile-hydrating activity over a broad pH range from 6.0 to 10.0 at 26°C. It hydrated 4-nitrophenylacetonitrile, 2-chlorobenzonitrile and 3-chlorobenzonitrile to their corresponding carboxylic acids and amides, while benzyl cyanide, benzonitrile, 4-tolunitrile, cyclohexanecarbonitrile, 4-chlorobutyronitrile and isobutyronitrile gave carboxylic acids as the sole products. The maximum whole-cell nitrile-hydrating activity was observed at pH 7.0.

4-[diaryl)hydroxymethyl]-1-piperidinealkylcarboxylic acids, salts and esters useful in the treatment of allergic disorders

Novel compounds useful in the treatment of allergic disorders and having the formula: STR1 where Ar and Ar1 are pyridinyl, phenyl, or substituted phenyl and where Y is --OH,--O? M≈ m,--O--loweralkyl, --O--Aryl, or NR1 R2 (R1, R2 =H, loweralkyl, aryl) are herein disclosed.