58977-36-9

Basic information

• Product Name: 6-phenylhexan-3-one
• Synonyms: 6-phenylhexan-3-one;1-Phenylhexane-4-one;6-Phenyl-3-hexanone;Einecs 261-531-3
• CAS NO: 58977-36-9
• Molecular Formula: C₁₂H₁₆O
• Molecular Weight: 176.25484
• EINECS: 261-531-3
• Mol File: 58977-36-9.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 278.5°C at 760 mmHg
• Flash Point: 124.3°C
• Appearance: /
• Density: 0.95g/cm³
• Vapor Pressure: 0.00425mmHg at 25°C
• Refractive Index: 1.498
• CAS DataBase Reference: 6-phenylhexan-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-phenylhexan-3-one(58977-36-9)
• EPA Substance Registry System: 6-phenylhexan-3-one(58977-36-9)

Safety Data

• Hazardous Substances Data: 58977-36-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H16O/c1-2-12(13)10-6-9-11-7-4-3-5-8-11/h3-5,7-8H,2,6,9-10H2,1H3

Upstream product

• 79-03-8 propionyl chloride 
• 2687-12-9 cinnamyl chloride 
• 925-90-6 ethylmagnesium bromide 
• 1821-12-1 4-Phenylbutyric acid 
• 75-89-8 2,2,2-trifluoroethanol 
• 64-19-7 acetic acid 
• 64-17-5 ethanol 
• 18496-54-3 phenylbutyric acid chloride 
• 60012-62-6 phenyl-1 hexanol-2 
• 2046-18-6 4-phenylbutyronitrile 
• 1462-75-5 3-phenylpropylmagnesium bromide 
• 90996-73-9 2-phenylthio-4,4-ethylenedioxythiane 
• 90996-72-8 2-phenylthiotetrahydro-4H-thiopyran-4-one 
• 42850-68-0 1,4-dioxa-8-thiaspiro[4.5]decane 

Downstream Products

• 60012-62-6 phenyl-1 hexanol-2 
• 58249-47-1 1-phenyl-3-cyclopropylpropane 

Relevant articles and documents

Synthesis of aliphatic ketones from allylic alcohols through consecutive isomerization and chelation-assisted hydroacylation by a rhodium catalyst

Abstract: An allylic alcohol, utilized as a precursor for an aliphatic aldehyde, reacted with olefins to afford aliphatic ketones in the presence of RhCl(PPh3)3, 2-amino-4-picoline, aniline, and benzoic acid through a tandem reaction of an isomerization and a chelation-assisted hydroacylation.

Solvolysis of 2,2-dialkylvinyl iodonium salt: Alkyl participation and possibility of a primary vinylic cation intermediate

Solvolysis of (E)- and (Z)-2-methyl-5-phenyl-1-pentenyl(phenyl)iodonium tetrafiuoroborate (1·BF4) was carried out in various alcohols, acetic acid, and aqueous solutions at 60 °C. Products (after acid hydrolysis) include iodobenzene and 2-methyl-5-phenylpentanal as well as rearranged ones: 6- phenyl-2-hexanone, 6-phenyl-3-hexanone, 6-phenyl-2-hexyne, 6-phenyl- 1,2- hexadiene, and 6-phenyl-2,3-hexadiene. The products of α-elimination, including 1-methyl-3-phenyl-1-cyclopentene, were also obtained in methanol and ethanol. Solvolysis of the E isomer (E)-1 is faster than that of (Z)-1 in every solvent examined. The percentage of rearrangement is higher with (E)-1 than with (Z)-1, and the main rearranged products are those of migration of the alkyl group trans to the iodonio group, but migration of the cis alkyl group is also involved. Theoretical calculations suggest that interconversion between the secondary Vinylic cations by 1,2-hydride shift is rapid. These results show that a major heterolysis reaction occurs with β-alkyl participation to directly give a secondary vinylic cation, but stereochemistry of the unrearranged substitution products suggests that formation of the primary vinylic cation is also involved in less nucleophilic solvents like acetic acid and 2,2,2-trifluoroethanol.

Solvolysis of β,β-dialkylvinyliodonium salt: Primary vinyl cation intermediate and alkyl participation

Solvolysis of both E and Z isomers of a β,β-dialkylvinyl-(phenyl)iodonium salt gave extensively rearranged products. A mechanism involving a primary vinyl cation intermediate as well as the alkyl participation leading to secondary vinyl cations is proposed.