58995-76-9

Upstream product

• 35447-83-7 N-(4-ethynylphenyl)acetamide 
• 143321-89-5 2,2,2-trifluoro-N-(2-iodophenyl)acetamide 
• 71052-82-9 acetic acid-[4-(1-phenylhydrazono-ethyl)-anilide] 
• 4248-19-5 tert-butyl carbazate 
• 1192159-84-4 C₁₆H₁₂BrNO 
• 100-63-0 phenylhydrazine 
• 2719-21-3 4-(N-acetylamino)acetophenone 

Downstream Products

• 21889-05-4 2-(4'-aminophenyl)indole 

Relevant academic research and scientific papers

Copper-catalyzed N-arylation/hydroamin(d)ation domino synthesis of indoles and its application to the preparation of a Chekl/KDR kinase inhibitor pharmacophore

Inexpensive copper catalysts allow for efficient syntheses of N-aryl-, N-acyl-, or N-H-(aza)in-doles starting from ortho-alkynylbromoarenes. The broad scope of this domino N-arylation/hydro-amin(d)ation process is highlighted by the synthesis of highly fu

2-Aryl and 2-Heteroaryl Indoles from 1-Alkynes and o- lodotrifluoroacetanilide through a Domino Copper-Catalyzed Coupling-Cyclization Process

(Matrix presented) A general method for the synthesis of 2-aryl and 2-heteroaryl indoles from aryl iodides and 1-alkynes through a domino copper-catalyzed process is reported. The best results have been obtained with [Cu(phen)(PPh3)2]NO3 in the presence of K 3PO4 in toluene or dioxane at 110°C. 2-Aryl and 2-heteroaryl indoles can also be isolated in good yields by using catalysts derived from Cul and PPh3 in dioxane at 110°C.

2-Phenyl-indole derivatives and process for preparing the same

New stabilizers of polymers and co-polymers of vinyl chloride, the said stabilizers being 2-phenyl-indole derivatives corresponding to the formula: STR1 wherein R represents a phenyl radical, an amino group, optionally substituted by an acetyl or benzoyl