35447-83-7

Usage

Uses

Used in Pharmaceutical Industry:
Acetamide, N-(4-ethynylphenyl)is used as a PDE10A inhibitor for the treatment of neurological and psychiatric disorders such as schizophrenia and Huntington's disease. Its ability to regulate neurotransmitter levels in the brain makes it a promising candidate for managing symptoms of these conditions.
Additionally, PDE10A inhibitors like Acetamide, N-(4-ethynylphenyl)-, have shown potential in the treatment of other neurological and neurodegenerative diseases, making them an important area of research in the pharmaceutical industry.

Upstream product

• 14235-81-5 4-Ethynylaniline 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 622-50-4 4-Acetamido-1-iodobenzene 
• 75867-39-9 4-trimethylsilylethynyl aniline 
• 122-85-0 para-acetamidobenzaldehyde 
• 90965-06-3 dimethyl 1-(1-diazo-2-oxopropyl)phosphonate 
• 471-25-0 Propiolic acid 
• 83345-11-3 N-[4-(2-hydroxylethyl)phenyl]acetamide 
• 540-37-4 p-aminoiodobenzene 
• 103-88-8 4-bromoacetanilide 
• 81854-47-9 N-(4-(2-(trimethylsilyl)ethynyl)phenyl)acetamide 

Downstream Products

• 35447-82-6 p-acetamido-α-bromostyrene 
• 1401785-24-7 C₂₃H₂₂BrN₅O₃ 
• 2719-21-3 4-(N-acetylamino)acetophenone 
• 1581755-89-6 (S)-4-((4-acetamidophenyl)ethynyl)-6-(hydroxymethyl)-N-(1-phenylethyl)picolinamide 
• 1581755-93-2 (S)-(4-((4-acetamidophenyl)ethynyl)-6-(1-phenylethylcarbamoyl)pyridin-2-yl)methyl methanesulfonate 
• 1581756-08-2 (R)-4-((4-acetamidophenyl)ethynyl)-6-(hydroxymethyl)-N-(1-phenylethyl)picolinamide 
• 130188-66-8 N-(4-(2-(phenylsulfonyl)acetyl)phenyl)acetamide 
• 1612885-68-3 N-(4-(1-((2R,3S,5R)-3-hydroxy-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)-1H-1,2,3-triazol-4-yl)phenyl)acetamide 
• 77252-62-1 5-(4-acetamidophenyl)-3-phenylisoxazole 

Relevant academic research and scientific papers

Visual detection of formaldehyde by highly selective fluorophore labeling via gold(iii) complex-mediated three-component coupling reaction

A novel method for visual detection of formaldehyde with excellent selectivity via a gold(iii) complex-mediated three-component coupling reaction of resin-linked sterically bulky amines and fluorescent alkynes has been developed.

Hydrazine Hydrate Accelerates Neocuproine–Copper Complex Generation and Utilization in Alkyne Reduction, a Significant Supplement Method for Catalytic Hydrogenation

Diimine (HN═NH) is a strong reducing agent, but the efficiency of diimine oxidized from hydrazine hydrate or its derivatives is still not good enough. Herein, we report an in situ neocuproine–copper complex formation method. The redox potential of this complex enable it can serve as an ideal redox catalyst in the synthesis of diimine by oxidation of hydrazine hydrate, and we successfully applied this technique in the reduction of alkynes. This reduction method displays a broad functional group tolerance and substrate adaptability as well as the advantages of safety and high efficiency. Especially, nitro, benzyl, boc, and sulfur containing alkynes can be reduced to the corresponding alkanes directly, which provides a useful complementary method to traditional catalytic hydrogenation. Besides, we applied this method in the preparation of the Alzheimer’s disease drug CT-1812 and studied the mechanism.

An Electrochemical Beckmann Rearrangement: Traditional Reaction via Modern Radical Mechanism

Abstract: Electrosynthesis as a potential means of introducing heteroatoms into the carbon framework is rarely studied. Herein, the electrochemical Beckmann rearrangement, i. e. the direct electrolysis of ketoximes to amides, is presented for the first time. Using a constant current as the driving force, the reaction can be easily carried out under neutral conditions at room temperature. Based on a series of mechanistic studies, a novel radical Beckmann rearrangement mechanism is proposed. This electrochemical Beckmann rearrangement does not follow the trans-migration rule of the classical Beckmann rearrangement.

INHIBITORS OF HEPATITIS C VIRUS REPLICATION

The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

SO2F2-Mediated Oxidative Dehydrogenation and Dehydration of Alcohols to Alkynes

Direct synthesis of alkynes from inexpensive, abundant alcohols was achieved in high yields (greater than 40 examples, up to 95% yield) through a SO2F2-promoted dehydration and dehydrogenation process. This straightforward transformation of sp3-sp3 (C-C) bonds to sp-sp (C=C) bonds requires only inexpensive and readily available reagents (no transition metals) under mild conditions. The crude alkynes are sufficiently free of impurities to permit direct use in further transformations, as illustrated by regioselective Huisgen alkyne-azide cycloaddition reactions with PhN3 to give 1,4-substituted 1,2,3-traiazoles (16 examples, up to 92% yield) and Sonogashira couplings (10 examples, up to 77% yield).

Multicomponent Oxidative Trifluoromethylation of Alkynes with Photoredox Catalysis: Synthesis of α-Trifluoromethyl Ketones

The direct oxidative addition of CF3 and H2O to alkynes was achieved with photoredox catalysis to obtain α-trifluoromethyl ketones via rapid enol-keto tautomerization. The reaction exhibits high functional group tolerance and regioselectivity. Heterocycles of various sizes containing CF3 were synthesized from the α-CF3-substituted diketones obtained through the protocol, thereby demonstrating the versatile applicability of the method. Mechanistic studies of the reaction with isotopes provided insight into the reaction pathway.

INDOLINONE DERIVATIVES AS INHIBITORS OF MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE

The present disclosure relates to indolinone compounds, compositions, and methods for the inhibition of maternal embryonic leucine zipper kinase (MELK). The present disclosure further relates to indolinone compounds, compositions, and methods for the treatment or prevention of a cancer (for example, triple negative breast cancer).

Visible-Light-Mediated Photoredox-Catalyzed Regio- and Stereoselective Chlorosulfonylation of Alkynes

Herein, a one-step chlorosulfonylation of alkynes via a photocatalytic redox process is described. A variety of commercially available sulfonyl chlorides can be applied for the generation of sulfonyl radical species under visible-light irradiation. Regio- and stereoselective addition of the sulfonyl radical and chloride leads to the efficient formation of (E)-selective β-chlorovinyl sulfones from a broad range of terminal and internal alkynes. The reported method represents an operationally simple and mild way to furnish vinyl sulfones.

Based on metal catalyzed coupling reaction of formaldehyde in food detection method and kit therefor (by machine translation)

The invention provides a method and a kit for detecting formaldehyde in food based on metal catalysis coupling reaction. The metal catalysis coupling reaction comprises that coupling reaction is carried out on formaldehyde, amine and alkyne in presence of

Pyrimidine or pyridine pyridine ketone compound and its preparation method and application (by machine translation)

The invention discloses a kind of type I of the pyrimidine or pyridine pyridine ketone compound and its preparation and application, which belongs to the technical field of pharmaceutical preparation. The compounds have high-efficient and selectively inhibit the cell cycle dependent kinases (Cdks) CDK4 and CDK6 active, and then by inhibiting CDK4/CDK6 prevent tumor cell division. Therefore, the compounds of this invention can be used for CDK4 and CDK6 the involved in cell cycle control disorders result in various diseases, especially suitable for the treatment of malignant tumors. (by machine translation)