59137-68-7

Upstream product

• 109-99-9 tetrahydrofuran 
• 13735-81-4 1-styrenyloxytrimethylsilane 
• 5371-52-8 2-hydroxytetrahydrofuran 
• 2206-94-2 1-acetoxy-1-phenylethene 
• 1245719-57-6 (E)-6-hydroxy-1-phenylhex-2-en-1-one 
• 60623-60-1 2-(phenylthio)tetrahydrofuran 
• 100-42-5 styrene 
• 98-86-2 acetophenone 
• 536-74-3 phenylacetylene 
• 621-82-9 Cinnamic acid 
• 197246-28-9 1-(2',2',6',6'-tetramethyl-1'-piperidinyloxy)-tetrahydrofuran 
• 57957-24-1 N-(1-phenylvinyl)acetamide 
• 1394313-89-3 6-phenylhex-5-yne-1,4-diol 
• 1608-67-9 2-acetoxytetrahydrofuran 

Relevant academic research and scientific papers

General, Straightforward, and Atom-Economical Synthesis of Vinyl Triflimides

Vinyl triflimides were only accessible recently and their chemistry is yet to be discovered. Herein, we describe a general, straightforward and atom-economical synthesis of these materials from alkynes and triflimide. A vast array of terminal and internal alkynes with broad spectrum of functionalities could be employed to generate various di- and trisubstituted vinyl triflimides regiospecifically with high to specific stereoselectivity. Moreover, the protocol could be conducted on gram scale using terminal and internal alkynes. Preliminarily attempts to probe the unprecedented reactivity of vinyl triflimides revealed part of its chemical properties.

Visible-light-promoted oxidative coupling of styrene with cyclic ethers

A new visible-light-promoted oxidative coupling of vinylarenes with cyclic ethers has been developed using rose bengal as photocatalyst and tert-butyl hydrogenperoxide (TBHP) as oxidant under ambient air at room temperature. A library of α-oxyalkylated ketones with broad functionalities has been synthesized in moderate to good yields. A radical mechanism is suggested for the present protocol.

Organocatalytic Enantioselective Cycloetherifications Using a Cooperative Cation-Binding Catalyst

A highly enantioselective cycloetherification strategy for the straightforward synthesis of enantioenriched tetrahydrofurans, tetrahydropyrans, and oxepanes using Song's cation-binding oligoEG catalyst and KF as the base is demonstrated. A wide range of ?

Method for performing decarboxylated oxidative coupling on cinnamic acid derivatives and cyclic ethers

The invention discloses a method for performing decarboxylated oxidative coupling on cinnamic acid derivatives and cyclic ethers. The method comprises the step of carrying out a one-pot reaction between the cinnamic acid derivatives and cyclic ethers in a

Transition-Metal-Free Oxidative Decarboxylative Cross Coupling of α,β-Unsaturated Carboxylic Acids with Cyclic Ethers under Air Conditions: Mild Synthesis of α-Oxyalkyl Ketones

A novel K2S2O8-promoted decarboxylative cross coupling of α,β-unsaturated carboxylic acids with cyclic ethers was developed under aerobic conditions. The present protocol, which includes C-C and C=O bond formation in one s

Method of decarboxylation oxidative coupling for [alpha], [beta]-unsaturated carboxylic acid and cyclic ether compound

The invention discloses a method of decarboxylation oxidative coupling for [alpha], [beta]-unsaturated carboxylic acid and a cyclic ether compound. In the method, under an oxygen-containing atmosphere, the [alpha], [beta]-unsaturated carboxylic acid and t

Catalytic Carbocation Generation Enabled by the Mesolytic Cleavage of Alkoxyamine Radical Cations

A new catalytic method is described to access carbocation intermediates via the mesolytic cleavage of alkoxyamine radical cations. In this process, electron transfer between an excited state oxidant and a TEMPO-derived alkoxyamine substrate gives rise to a radical cation with a remarkably weak C?O bond. Spontaneous scission results in the formation of the stable nitroxyl radical TEMPO.as well as a reactive carbocation intermediate that can be intercepted by a wide range of nucleophiles. Notably, this process occurs under neutral conditions and at comparatively mild potentials, enabling catalytic cation generation in the presence of both acid sensitive and easily oxidized nucleophilic partners.

MnO2-Catalyzed Oxidative Alkylation of Enamides with Ethers via C(sp3)-H/C(sp2)-H Cross-Dehydrogenative Coupling and Hydrolysis Sequence

A new MnO2-catalyzed oxidative alkylation of enamides with a C(sp3)-H bond adjacent to an oxygen atom is described. This method achieves a C(sp3)-H/C(sp2)-H cross-dehydrogenative coupling and hydrolysis, thus pr

Gold(I)/(III)-catalyzed synthesis of cyclic ethers; Valency-controlled cyclization modes

Strategic use of oxophilic (hard) gold(III) and π-philic (soft) gold(I) catalysts provides access to two types of cyclic ethers from propargylic alcohols. Thus, heating propargylic alcohols with an oxophilic gold(III) catalyst (AuBr3) results i

Practical and highly selective C-H functionalization of structurally diverse ethers

A trityl ion mediated C-H functionalization of ethers with a wide range of nucleophiles at ambient temperature has been developed. The reaction displays high chemo-selectivity and good functional group tolerance. The protocol also exhibits excellent regio- and diastereoselectivities for the unsymmetric ethers, thus stereoselectively generating highly functionalized disubstituted 2,5-trans tetrahydrofurans (THF), 2,6-trans tetrahydropyrans (THP), 2,6-trans dihydropyrans (DHP), and 1,3-trans isochromans, and highlighting the capacity of the protocol in complex molecule synthesis.