59163-72-3

Usage

Physical state

Clear, colorless liquid

Aroma

Sweet, floral

Uses

Fragrance ingredient in perfumes and personal care products; flavoring agent in baked goods and confections

Derivation

Acetic acid and 4-chlorophenyl-2-ethanol

Precautions

Can be irritating to skin, eyes, and respiratory system if not properly handled

Upstream product

• 108-90-7 chlorobenzene 
• 6948-71-6 toluene-4-sulfonic acid 2-(4-chloro-phenyl)-ethyl ester 
• 64-19-7 acetic acid 
• 1878-66-6 4-chlorophenylacetic Acid 
• 75-36-5 acetyl chloride 
• 1875-88-3 2-(4-Chlorophenyl)ethanol 
• 108-24-7 acetic anhydride 
• 502699-22-1 2-[2-(4-chloro-phenyl)-ethoxy]-tetrahydro-pyran 

Relevant academic research and scientific papers

ZrCl4 as a mild and efficient catalyst for the one-pot conversion of TBS and THP ethers to acetates

A mild, efficient and chemoselective method has been developed for the direct transformation of tert-butyldimethylsilyl and tetrahydropyranyl protected alcohols into the corresponding acetates with acetic anhydride and zirconium(IV) chloride as the catalyst in acetonitrile, in a one-pot reaction with high yields and short reaction times. This method has been applied to a variety of substrates.

A fast and practical approach to tetrahydropyranylation and depyranylation of alcohols using indium triflate

Indium triflate-mediated tetrahydropyranylation of alcohols in dichloromethane and depyranylation of these products in aqueous methanol utilizing the same reagent but different molar ratio is described. In addition, indium triflate-promoted conversion of tetrahydropyran ethers to their corresponding acetates has also been described.

Rapid and efficient acetylation of alcohols and phenols with acetic anhydride using tin(IV) porphyrin as catalyst

The efficient and rapid esterification of alcohols and phenols in acetic anhydride was achieved by tin(IV) tetraphenylporphyrin perchlorate [SnIV (tpp) (ClO4)2] as catalyst in high yields. SnIV (tpp) (ClO4)2 showed highly catalytic activity on the acetylation reaction.

Substituent Effects. XVI. Acetolysis of 2-Phenylethyl Tosylates

The acetolysis rates of 2-arylethyl tosylates were determined for a series of aryl substituents.The non-linear substituent effect was reasonably accounted for on the basis of two linear LArSR relationships; one for the aryl-assisted (FkΔ) and one for the unassisted (Ks) process, respectively.A precise dissection of the apparent substituent effect into individual effects for both processes was achieved in this manner.The substituent effect on the ks process can be described as a linear function of ?0 with a small ρs of -0.19, and that on the FkΔ process in terms of the LArSR Eq., with a ρΔ=-3.87 and an rΔ=0.631.The use of ?+ for the FkΔ process failed to give any reasonable dissection.The r value for this FkΔ process is essentially identical to that for the neophyl solvolysis.The unique r value oh 0.6 is concluded to be characteristic of β-aryl-assisted ionization processes in general.