593-92-0Relevant articles and documents
Catalytic Enantioselective Synthesis of 1,4-Keto-Alkenylboronate Esters and 1,4-Dicarbonyls
Liang, Michael Z.,Meek, Simon J.
supporting information, p. 14234 - 14239 (2019/08/30)
A catalytic enantioselective method for the synthesis of 1,4-keto-alkenylboronate esters by a rhodium-catalyzed conjugate addition pathway is disclosed. A variety of novel, bench-stable alkenyl gem-diboronate esters are synthesized. These easily accessible reagents react smoothly with a collection of cyclic α,β-unsaturated ketones, generating a new C?C bond and stereocenter. Products are isolated in up to 99 % yield with greater than 20:1 E/Z and greater than 99:1 e.r. Mechanistic studies show the site-selectivity of transmetalation and reactivity is ligand dependent. The utility of the approach is highlighted by gram-scale synthesis of enantioenriched cyclic 1,4-diketones, and stereoselective transformations of the products by hydrogenation, allylation, and isomerization.
Method for producing 1,1-dibromo-1-fluoroethane
-
Paragraph 0120; 0121, (2016/11/21)
The present invention addresses the problem of providing a production method which enables 1,1-dibromo-1-fluoroethane to be produced in a simple and sustained manner. The present invention provides a method for producing 1,1-dibromo-1-fluoroethane, said method comprising step A of reacting 1,1-dibromoethylene with hydrogen fluoride to produce 1,1-dibromo-1-fluoroethane.
PRODUCTION METHOD OF MONOFLUOROETHYLENE COMPOUND
-
Paragraph 0041, (2016/12/22)
PROBLEM TO BE SOLVED: To provide a synthesis method capable of giving a monofluoroethylene compound with a difluoroethylene compound as a material, under mild conditions, at ease and with high selectivity. SOLUTION: A production method of a monofluoroethylene compound represented by the formulas (1-1), (1-2) or (1-3) comprises a step of a difluoroethylene compound represented by the formulas (2-1), (2-2) or (2-3) with a compound represented by the formula (3): BX3, to obtain a monofluoroethylene compound represented by the formulas (1-1), (1-2) or (1-3). [R1 and R2 may be identically or differently H, an alkyl group, or a phenyl group which may be substituted with one or more substituent groups, or may be linked to each other to form a carbocyclic ring; and X is Cl or Br.] COPYRIGHT: (C)2015,JPOandINPIT