5948-72-1

Usage

Uses

Used in Pharmaceutical Synthesis:
Ethyl 4-methyl-2-oxo-6-thiophen-2-yl-3,6-dihydro-1H-pyrimidine-5-carboxylate serves as a building block in the creation of various pharmaceuticals. Its unique structure allows it to be a key intermediate in the synthesis of drugs targeting specific biological pathways or receptors.
Used in Chemical Research:
As a research tool, ethyl 4-methyl-2-oxo-6-thiophen-2-yl-3,6-dihydro-1H-pyrimidine-5-carboxylate aids scientists in understanding the relationship between chemical structure and biological activity. It can be utilized to investigate the mechanisms of drug action, develop new synthetic methodologies, and explore the boundaries of medicinal chemistry.
Used in Biological Studies:
In biological research, ethyl 4-methyl-2-oxo-6-thiophen-2-yl-3,6-dihydro-1H-pyrimidine-5-carboxylate can be employed to study the interactions between small molecules and biological targets such as enzymes, receptors, or nucleic acids. It may also be used to screen for potential therapeutic agents or to understand the molecular basis of diseases.
Used in Drug Development:
Ethyl 4-methyl-2-oxo-6-thiophen-2-yl-3,6-dihydro-1H-pyrimidine-5-carboxylate holds promise in drug development due to its potential medicinal properties. It can be optimized and modified to create new drug candidates with improved efficacy, selectivity, and safety profiles for the treatment of various diseases.
Used in Material Science:
Beyond its pharmaceutical applications, ethyl 4-methyl-2-oxo-6-thiophen-2-yl-3,6-dihydro-1H-pyrimidine-5-carboxylate may also find use in the development of new materials with specific properties. Its unique structure could contribute to the creation of advanced materials for various industries, such as electronics, where its electronic properties could be harnessed.

InChI:InChI=1/C12H14N2O3S/c1-3-17-11(15)9-7(2)13-12(16)14-10(9)8-5-4-6-18-8/h4-6,10H,3H2,1-2H3,(H2,13,14,16)

Upstream product

• 198826-88-9 ethyl 2-methoxy-6-methyl-4-(2-thienyl)-1,4-dihydropyrimidine-5-carboxylate 
• 98-03-3 thiophene-2-carbaldehyde 
• 188290-36-0 thiophene 
• 6214-64-8 6-methyl-2-oxo-1,2-dihydropyrimidine-5-carboxylic acid ethyl ester 
• 141-97-9 ethyl acetoacetate 
• 99902-07-5 2-(2-thienyl)benzaldehyde 
• 57-13-6 urea 
• 554-14-3 2-Methylthiophene 
• 17994-55-7 6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester 
• 2786-07-4 2-thienyl lithium 
• 636-72-6 2-thiophenemethanol 

Downstream Products

• 15139-62-5 2-Oxo-5-ethoxycarbonyl-6-brommethyl-4--1,2,3,4-tetrahydro-pyrimidin 

Relevant academic research and scientific papers

Microwave-assisted efficient synthesis of dihydropyrimidines in solvent-free condition

An efficient synthesis of 3,4-dihydropyrimidinones from an aldehyde, a ketoester, and a urea or thiourea using a catalytic amount of ferric chloride hexahydrate is described. Microwave irradiation has been used to accelerate the synthesis of the Biginelli

Magnetic Silica-Coated Picolylamine Copper Complex [Fe3O4@SiO2@GP/Picolylamine-Cu(II)]-Catalyzed Biginelli Annulation Reaction

An efficient and heterogeneous novel magnetic silica-coated picolylaminecopper complex [Fe3O4@SiO2@GP/Picolylamine-Cu(II)] was synthesized, characterized, and employed as a magnetically recoverable nanocatalyst in Biginelli condensation for the preparatio

Titanium tetrachloride immobilized on cross-linked poly(N-vinyl-2-pyrrolidone) as a recyclable heterogeneous catalyst for one-pot three component synthesis of 3, 4-dihydropyrimidin-2(1H)-ones/thiones

A new catalytic application of titanium tetrachloride immobilized on the cross-linked poly(N-vinyl-2-pyrrolidone) carrier as beads, TiCl4/PNVP, as a recoverable and heterogeneous macromolecular Lewis acidic catalyst is developed. This catalytic system allowed for the facile and cleaner synthesis of 3,4-dihydro pyrimidin-2(1H)-ones/thiones in high yields with TON up to 23.2 through the Biginelli three-component cyclocondensation reaction in ethanol. The reusability test ascertained that this heterogeneous titanium catalyst can be easily separated from the reaction mixture by simple filtration and reused several times with no great decline of activity.

Poly(N-vinyl-2-pyrrolidone)-supported ferric chloride: An effective reusable heterogeneous catalyst for one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via three-component Biginelli reaction

An environmentally benign three-component Biginelli protocol for the one-pot synthesis of substituted 3,4-dihydropyrimidin-2(1H)-ones/thiones using an accessible, nontoxic, easy to handle, and recoverable macromolecular Lewis acidic catalyst is developed.

Deep eutectic solvent assisted synthesis of dihydropyrimidinones/thionesviaBiginelli reaction: theoretical investigations on their electronic and global reactivity descriptors

Deep eutectic solvents formed from hydrated metal chlorides and hydrogen bond donors (Type 4) were prepared and their catalytic activity was compared for the synthesis of dihydropyrimidinones/thionesviaBiginelli reaction at room temperature. The one-pot m

3,4-Dihydropyrimidin-2(1 H)-ones as Antagonists of the Human A2BAdenosine Receptor: Optimization, Structure-Activity Relationship Studies, and Enantiospecific Recognition

We present and thoroughly characterize a large collection of 3,4-dihydropyrimidin-2(1H)-ones as A2BAR antagonists, an emerging strategy in cancer (immuno) therapy. Most compounds selectively bind A2BAR, with a number of potent and selective antagonists fu

Tungsten-substituted molybdophosphoric acid impregnated with kaolin: effective catalysts for the synthesis of 3,4-dihydropyrimidin-2(1: H)-ones v i a biginelli reaction

A series of highly reusable heterogeneous catalysts (10-25 wt% PMo7W5/kaolin), consisting of tungsten-substituted molybdophosphoric acid, H3PMo7W5O40·24H2O (PMo7W5) impregnated with acid treated kaolin clay was synthesized by the wetness impregnation meth

Application of design of experiments (Doe) approach for the optimization of phase-transfer catalyzed biginelli dihydropyrimidinone (dhpm) synthesis

The conventional Biginelli synthesis is more cumbersome and produces lower yields. Several improved methods are reported in the literature to replace the Biginelli catalyst. The design of biocompatible organic transformation is a major concern and a versa

1, 1'-sulfinyldiethylammonium bis (hydrogen sulfate) as a recyclable dicationic ionic liquid catalyst for the efficient solvent-free synthesis of 3, 4-dihydropyrimidin-2(1H)-ones Via biginelli reaction

Objective: A facile and efficient method for synthesis of 3, 4-dihydropyrimidin-2(1H)-ones via Biginelli reaction catalyzed by a novel dicationic Br?nsted acidic ionic liquid, [(EtNH2)2SO][HSO4]2, has been succe

Efficient one-pot synthetic methods for the preparation of 3,4-dihydropyrimidinones and 1,4-dihydropyridine derivatives using BNPs?SiO2(CH2)3NHSO3H as a ligand and metal free acidic heterogeneous nano-catalyst

Heterocyclic compounds with biological and pharmacological activates like 3,4-dihydropyrimidin-2-(1H)-ones and 1,4-dihydropyridines have attracted great interest. Boehmite nanoparticles functionalized with silylpropyl sulfamic acid (BNPs?SiO2(C