59490-95-8

Upstream product

• 13228-36-9 5-methyl-2-phenyl-1H-indole 
• 67-56-1 methanol 
• 15104-17-3 2-phenyl-6-methyl-1,4-dihydro-4-oxoquinoline 
• 2941-78-8 2-Amino-5-methylbenzoic acid 
• 98-88-4 benzoyl chloride 
• 147779-36-0 3,3-dichloro-6-methyl-2-phenylquinolin-4(3H)-one 
• 106-49-0 p-toluidine 
• 93-97-0 benzoic acid anhydride 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 117039-85-7 6-methyl-2-phenyl-4H-benzo[d][1,3]oxazin-4-one 
• 21419-51-2 6-methyl-2-phenylquinazolin-4(3H)-one 

Relevant academic research and scientific papers

Production of 3-Benzoyl-2,1-benzisoxazoles, 2-Phenyl-4H-3,1-benzoxazin-4-ones, and Novel Quinolinone Derivatives from 2-Phenylquinolin-4(1H)-ones and Sodium Dichloroisocyanurate

A simple synthesis of certain 3-benzoyl-2,1-benzisoxazoles 6 is accomplished via treatment of the corresponding 2-phenylquinolin-4(1H)-one 1 with sodium dichloroisocyanurate 2 in methanolic aq. alkali; the isomeric 2-phenyl-4H-3,1-benzoxazin-4-one 7 is al

Hypolipidemic 2-[4-(1,1-dimethylethyl)phenyl]-4H-3,1-benzoxazin-4-ones. Structure-activity relationships of a novel series of high-density lipoprotein elevators

The preparation and plasma lipid altering characteristics of a series of 4H-3,1-benzoxazin-4-ones are described. Hypocholesterolemic, hypotriglyceridemic, and high-density-lipoprotein elevating properties are found for derivatives bearing a 4-(1,1-dimethylethyl)phenyl group at the 2-position, and this activity is displayed in both hypercholesterolemic and in normolipidemic rats when the ring system is substituted at position 6 with hydrogen, methyl, chloro, or iodo groups, and is optimal when the 6-position is substituted by a bromine atom. Evidence is presented suggesting that a metabolite or degradation product is responsible for the changes in lipoprotein concentration observed with active molecules of this type. Synthesis of anticipated degradation products of the active molecules gave products displaying the expected in vivo activity, but no improvement in the narrow therapeutic margin of the best compound, 6-bromo-2-[4-(1,1-dimethylethyl)phenyl]-4H-3,1-benzoxazin-4-one, was obtained.

Substituted 2-arylquinazolines as fungicides

Fungicidal compositions based on substituted 2-arylquinazolines exhibit antifungal activity particularly against rusts and mildews. The synthesis of new compounds is described and the utility of antifungal compositions is exemplified.