59495-69-1

Usage

Chemical Properties

White to off-white powder

Upstream product

• 100-02-7 4-nitro-phenol 
• 10257-32-6 D-ribose 
• 6974-32-9 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose 
• 535960-66-8 p-nitrophenyl 2-O-(4'-O-acetylferuloyl)-3,5-di-O-acetyl-α-L-arabinofuranoside 
• 535960-67-9 p-nitrophenyl 5-O-(4'-O-acetylferuloyl)-2,3-di-O-acetyl-α-L-arabinofuranoside 
• 1235988-90-5 p-nitrophenyl 3-O-(4'-O-acetylferuloyl)-2,5-di-O-acetyl-α-L-arabinofuranoside 
• 13039-64-0 (2S,3R,4R)-2-(hydroxymethyl)-5-methoxytetrahydrofuran-3,4-diol 
• 189074-35-9 1-O-Acetyl-2,3,5-tri-O-benzoyl-α/β-L-arabinofuranoside 
• 5328-37-0 L-arabinose 
• 404574-12-5 methyl 2,3,5-tri-O-benzoyl-1-α-L-arabinofuranoside 
• 535960-65-7 p-nitrophenyl 3,5-di-O-acetyl-α-L-arabinofuranoside 
• 56272-01-6 1,2,3,5-tetra-O-acetyl-L-arabinofuranose 
• 880491-85-0 p-nitrophenyl 2,5-di-O-acetyl-α-L-arabinofuranoside 
• 100645-43-0 p-nitrophenyl 2,3,5-tri-O-benzoyl-α-L-arabinofuranoside 

Downstream Products

• 535960-68-0 p-nitrophenyl 3,5-O-(1,1,3,3-tetraisopropyldisiloxane)-α-L-arabinofuranoside 
• 134149-34-1 allyl-α-L-arabinofuranoside 
• 880491-85-0 p-nitrophenyl 2,5-di-O-acetyl-α-L-arabinofuranoside 
• 535960-65-7 p-nitrophenyl 3,5-di-O-acetyl-α-L-arabinofuranoside 
• 535960-64-6 4-nitrophenyl 2,3,6-tri-O-acetyl-5-deoxy-α-L-arabino-hexofuranoside 
• 535960-66-8 p-nitrophenyl 2-O-(4'-O-acetylferuloyl)-3,5-di-O-acetyl-α-L-arabinofuranoside 
• 59997-96-5 p-nitrophenyl α-L-arabinofuranosyl-(1->5)-α-L-arabinofuranoside 
• 1228460-05-6 p-nitrophenyl α-L-arabinofuranosyl-(1->5)-[α-L-arabinofuranosyl-(1->2)]-α-L-arabinofuranoside 
• 1228460-04-5 p-nitrophenyl α-L-arabinofuranosyl-(1->5)-α-L-arabinofuranosyl-(1->5)-α-L-arabinofuranoside 
• 1228460-03-4 p-nitrophenyl α-L-arabinofuranosyl-(1->2)-α-L-arabinofuranosyl-(1->2)-α-L-arabinofuranoside 
• 100-02-7 4-nitro-phenol 
• 127086-72-0 2',3'-O-(o,o'-biphenylenemethylidene)-1',5'-cycloribofuranose 
• 116910-88-4 p-nitrophenyl 2',3'-O-(o,o'-biphenylenemethylidene)ribofuranoside 
• 102045-32-9 methyl α-L-arabinofuranoside 

Relevant academic research and scientific papers

Direct Synthesis of para-Nitrophenyl Glycosides from Reducing Sugars in Water

Reducing sugars may be directly converted into the corresponding para-nitrophenyl (pNP) glycosides using 2-chloro-1,3-dimethylimidazolinium chloride (DMC), para-nitrophenol, and a suitable base in aqueous solution. The reaction is stereoselective for sugars with either a hydroxyl or an acetamido group at position 2, yielding the 1,2-trans pNP glycosides. A judicious choice of base allows extension to di-and oligosaccharide substrates, including a complex N-glycan oligosaccharide isolated from natural sources, without the requirement of any protecting group manipulations

Preparation of p-nitrophenyl β-l-arabinofuranoside as a substrate of β-l-arabinofuranosidase

Synthesis of p-nitrophenyl β-l-arabinofuranoside 1 as the substrate for novel β-l-arabinofuranosidase has been achieved by using both our inter- and intra-molecular glycosylation methodologies. Although the intermolecular glycosylation with l-Araf donors 3 and 4 resulted in a mixture of both α- and β-isomers, NAP ether-mediated IAD with 3 and 6 afforded the desired β-l-arabinofuranoside stereospecifically which was confirmed by NMR analysis on the 3JH1-H2 coupling constant and 13C chemical shift of C1. As expected, 1 has been revealed to be an efficient substrate in the biological study of a novel β- arabinofuranosidase such as HypBA1 with higher apparent affinity compared with other reported substrates.

Preparation of regioselectively feruloylated p-nitrophenyl α-l-arabinofuranosides and β-d-xylopyranosides-convenient substrates for study of feruloyl esterase specificity

p-Nitrophenyl α-l-arabinofuranoside and β-d-xylopyranoside mono-O-ferulates were prepared by 4-O-acetylferuloylation of corresponding enzymatically prepared di-O-acetates followed by deacetylation. An alternative mild acylation catalysed by zinc oxide was tested on xylopyranoside derivatives. The chemoselective methanolysis of the acetyl groups using neutral catalyst dibutyltin oxide at reflux was used as deacetylation method. Under these conditions a significant feruloyl migration was observed mainly on p-nitrophenyl 3-O-feruloyl-β-d-xylopyranoside resulting in low yields of the positional isomers. Investigation of substrate and positional specificity of different types of feruloyl esterases on the presented compounds in enzyme-coupled assays was reported previously.

The acetates of p-nitrophenyl α-L-arabinofuranoside - Regioselective preparation by action of lipases

All possible di-O-acetates and mono-O-acetates of p-nitrophenyl α-l-arabinofuranoside were prepared by chemoenzymatic way using lipases. The 2,3-di-O-acetate was obtained in 90% yield by deacetylation of the primary acetyl group of per-O-acetylated p-nitr

Enzymatic synthesis of alkyl arabinofuranosides using a thermostable α-L-arabinofuranosidase

A thermostable α-L-arabinofuranosidase was tested for its ability to perform transglycosylation with different alcohol acceptors. Reactions were characterized by high rates with optimal synthesis being obtained within 10 min. Both primary and secondary al

ENZYME DETECTION/ASSAY METHOD AND SUBSTRATES

The invention relates to a method of detecting and/or assaying nucleoside hydrolases or nucleoside phosphorylases using a chromogenic substrate. Preferred chromogenic substrates have formula (I) where X is OH, or H, and Y is the residue of Y—OH where Y—OH is a chromophore or a compound readily converted to a chromophore and the substrates are hydrolysed by the nucleoside hydrolase to yield ribose or 2-deoxyribose plus Y—OH. Alternatively those substrates may be phosphorylysed by nucleoside phosphorylase to yield ribose-1-phosphate plus Y—OH. The methods may be used to detect and/or assay parasites in biological samples.