595-45-9

Upstream product

• 141-82-2 malonic acid 
• 600-31-7 2-bromomalonic acid 
• 67-66-3 chloroform 
• 7726-95-6 bromine 
• 13479-49-7 tris(1,10-phenanthroline)iron(III) 
• 15541-45-4 bromate 

Downstream Products

• 37167-59-2 dimethyl dibromomalonate 
• 473-90-5 acetonedicarboxylic acid 
• 631-64-1 dibromoacetic acid 
• 141-82-2 malonic acid 
• 600-31-7 2-bromomalonic acid 
• 21465-56-5 2,7-bis-(4-methyl-anilino)-1,6-dithia-3,8-diaza-spiro[4.4]nona-2,7-diene-4,9-dione 
• 21465-55-4 2,7-bis-(2-methyl-anilino)-1,6-dithia-3,8-diaza-spiro[4.4]nona-2,7-diene-4,9-dione 
• 21352-52-3 2,7-bis-(3-chloro-anilino)-1,6-dithia-3,8-diaza-spiro[4.4]nona-2,7-diene-4,9-dione 
• 21352-63-6 3,8-di-o-tolyl-2,7-bis-o-tolylimino-1,6-dithia-3,8-diaza-spiro[4.4]nonane-4,9-dione 
• 21352-56-7 2,7-bis-(4-bromo-anilino)-1,6-dithia-3,8-diaza-spiro[4.4]nona-2,7-diene-4,9-dione 
• 21352-57-8 2,7-bis-(4-nitro-anilino)-1,6-dithia-3,8-diaza-spiro[4.4]nona-2,7-diene-4,9-dione 
• 21352-58-9 2,7-bis-(4-methyl-3-nitro-anilino)-1,6-dithia-3,8-diaza-spiro[4.4]nona-2,7-diene-4,9-dione 
• 21352-59-0 2,7-bis-(2-methyl-5-nitro-anilino)-1,6-dithia-3,8-diaza-spiro[4.4]nona-2,7-diene-4,9-dione 
• 72752-94-4 2,7-bis-[4-(4-chloro-phenyl)-thiazol-2-ylamino]-1,6-dithia-3,8-diaza-spiro[4.4]nona-2,7-diene-4,9-dione 

Relevant academic research and scientific papers

Synthesis of a New Fluorescent Probe Specific for Catechols

(Matrix Presented) The synthesis of a new fluorescent probe, specific for the cathechol moiety, has been conducted by preparation of α,α-dibromomalonamides containing an appropriate fluorophore. N,N′-Bis-anthracen-9-ylmethyl-2,2-dibromomalonamide reacted with various catechols in the presence of cesium carbonate to generate highly fluorescent derivatives.

Cyclic amic acid derivatives

PCT No. PCT/JP97/00303 Sec. 371 Date Aug. 4, 1998 Sec. 102(e) Date Aug. 4, 1998 PCT Filed Feb. 7, 1997 PCT Pub. No. WO97/29078 PCT Pub. Date Aug. 14, 1997The present invention relates to a compound of the formula (I), or its pharmaceutically acceptable salt or ester: wherein Ar1 is an aryl group or a heteroaromatic ring group; Ar is a group of the formula each of Ar2 and Ar3 is an aryl group or a heteroaromatic ring group; Cy is an aryl group, a heteroaromatic ring group or an aliphatic ring group which may contain one or two oxygen atoms; A1 is a C1-4 chain hydrocarbon group; m is an integer of from 1 to 6; each of n and p is an integer of from 0 to 3; Q1 is a single bond, a group of the formula -CH2O-, -OCH2-, -CH2S- or -SCH2-, or a C1-6 chain hydrocarbon group; Q2 is a single bond or a group of the formula -(CH2)m- or -(CH2)n-W-(CH2)p-; Q3 is a single bond, an oxygen atom, a sulfur atom, a methylene group, a vinylene group or a group of the formula -CO-, -NH-, -COO-, -OCO-, -CH2CH2-, -OCH2-, -SCH2-, -CH2O-, -CH2S-, -NHCO- or -CONH-; R1 is a lower alkyl group; each of R2 and R3 is a hydrogen atom, a hydroxyl group or a lower alkyl group; W is an oxygen atom, a sulfur atom, a vinylene group or an ethynylene group; x is an integer of from 0 to 2; and y is 0 or 1; and an antitumor agent containing it as an active ingredient and intermediates for the production thereof.

8H-ANHYDRO-4-HYDROXY-2-OXO-1,3-THIAZINUM HYDROXIDES AS MESOIONIC 1,4-DIPOLES

The previously unknown 8H-anhydro-4-hydroxy-2-oxo-1,3-thiazinum hydroxides (1) were prepared and their 1,4-dipolar cycloaddition behavior was examined.In most cases, elimination of the proton in the 8-position of the mesoionic ring was observed to occur unless extremely reactive dipolarophiles were used.The S,N-ketene acetals were converted to the corresponding α-diazo ketones for further study.

8H-Anhydro-4-hydroxy-2-oxo-1,3-thiazinium Hydroxides as mesoionic 1,4-Dipoles

The previously unknown 8H-anhydro-4-hydroxy-2-oxo-1,3-thiazinium hydroxides (1) were prepared and their 1,4-dipolar cycloaddition behavior was examined.In most cases, elimination of the proton in the 8-position of the mesoionic ring was observed to occur unless extremely reactive dipolarophiles were used.The S,N-ketene acetals were converted to the corresponding α-diazo ketones for further study.

Mechanism and Mathematical Model of the Oscillating Bromate-Ferroin-Bromomalonic Acid Reaction

A mechanism for the oscillatory reaction of the ferroin-catalyzed bromomalonic acid oxidation by bromate is proposed.The mechanism involves eleven steps.The corresponding mathematical model is reduced to a second-order system of differential equations.The model obtained is in good agreement with experiment.