5957-85-7

Upstream product

• 5029-67-4 2-iodopyridine 
• 108-90-7 chlorobenzene 
• 766-84-7 3-chloro-benzonitrile 
• 74-86-2 acetylene 
• 109-04-6 2-bromo-pyridine 
• 33756-91-1 tris(3-chlorophenyl)bismuthane 
• 89694-48-4 5-chloro-2-methoxyphenyl boronic acid 
• 1182190-89-1 2-(5-chloro-2-methoxyphenyl)pyridine 
• 110-86-1 pyridine 
• 108-42-9 3-chloro-aniline 
• 98-98-6 2-Picolinic acid 
• 1008-89-5 2-phenylpyridine 
• 2312-23-4 m-chlorophenylhydrazine hydrochloride 
• 585524-80-7 2-(3-chlorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane 

Downstream Products

• 1217887-34-7 C₁₂H₇ClF₃N 
• 1393520-24-5 4-chloro-N-phenyl-2-(pyridin-2-yl)benzamide 
• 1459258-91-3 dibutyl (4-chloro-2-(pyridin-2-yl)phenyl)phosphonate 
• 1498234-63-1 methyl 4-((4-chloro-2-(pyridin-2-yl)phenyl)(hydroxy)amino)benzoate 
• 383128-12-9 2-(3-chlorophenyl)piperidine 
• 1236046-59-5 (4-chloro-2-(pyridin-2-yl)phenyl)(phenyl)methanone 
• 1334336-16-1 α-phenyl-(4-chloro-2-(pyridin-2-yl))benzyl alcohol 
• 1418179-11-9 C₂₅H₂₁ClN₂O₂S 
• 1325592-74-2 N-phenyl-3-(pyridine-2-yl)aniline 
• 1325592-59-3 N-phenyl-N-(3-(pyridin-2-yl)phenyl)isoquinolin-1-amine 

Relevant academic research and scientific papers

Cp*Rh(iii)/boron hybrid catalysis for directed C-H addition to β-substituted α,β-unsaturated carboxylic acids

The C-H bond addition reaction of 2-phenylpyridine derivatives with α,β-unsaturated carboxylic acids catalyzed by Cp*Rh(iii)/BH3·SMe2is reported. Activation of C-H bonds with the rhodium catalyst and activation of α,β-unsaturated carboxylic acids with the boron catalyst cooperatively work, and a BINOL-urea hybrid ligand significantly improved the reactivity. With the optimized hybrid catalytic system, various β-disubstituted carboxylic acids were obtained under mild reaction conditions.

Chromium-Catalyzed Reductive Cleavage of Unactivated Aromatic and Benzylic C-O Bonds

Reductive cleavage of aromatic and benzylic C-O bonds by chromium catalysis is reported. This deoxygenative reaction was promoted by low-cost CrCl 2precatalyst combined with poly(methyl hydrogen siloxane) as the mild reducing agent, providing a strategy in forming reduced motifs by cleavage of unactivated C-O bonds. A range of functional groups such as bromide, chloride, fluoride, hydroxyl, amino, and alkoxycarbonyl can be retained in the reduction.

Ruthenium-Catalyzed ortho- And meta-H/D Exchange of Arenes

Ruthenium-catalyzed aromatic H/D exchange in [D4]acetic acid has been developed. By using N-heteroarenes as directing groups, both ortho and meta positions are selectively deuterated with high levels of D incorporation. Moreover, this strategy provides an alternative way to achieve meta-C-H activation.

Transition-Metal-Free Decarboxylative Arylation of 2-Picolinic Acids with Arenes under Air Conditions

A facile, transition-metal-free, and direct decarboxylative arylation of 2-picolinic acids with simple arenes is described. The oxidative decarboxylative arylation of 2-picolinic acids with arenes proceeds readily via N-chloro carbene intermediates to afford 2-arylpyridines in satisfactory to good yields under transition-metal-free conditions. This new type of decarboxylative arylation is operationally simple and scalable and exhibits high functional-group tolerance. Various synthetically useful functional groups, such as halogen atoms, methoxycarbonyl, and nitro, remain intact during the decarboxylative arylation of 2-picolinic acids.

Facile C–H arylation using catalytically active terminal sulfurs of 2 dimensional molybdenum disulfide

The first methodology of C–H arylation of heteroarene via 2D transition metal dichalcogenides that have catalytically active edge functional groups was described. The terminal sulfur groups could effectively catalyze a formation of an azo-linked intermediate with aryl diazonium salts, leading to produce heteroarenes with good yields. This novel methodology using bulk 2D transition metal dichalcogenides that have catalytically active edge functional groups can apply for various reactions to achieve C–C bond formation in the fields of heterogeneous catalysis that is easily separable, highly reusable, and inexpensive method.

Ligand-promoted ruthenium-catalyzed: Meta C-H chlorination of arenes using N -chloro-2,10-camphorsultam

A practical meta C-H chlorination protocol is established via a Ru(0)-catalyzed ortho-metalation strategy. The use of N-chloro-2,10-camphorsultam as a new chlorinating agent is crucial for the success of the current reaction and an N-heterocyclic carbene (NHC) ligand could significantly enhance the reactivity of the catalytic transformation. The mechanistic studies reveal that an unusual ortho C-H ruthenation relay process with ortho chlorination of the C-Ru bond is probably involved.

Chelation-Assisted Copper-Mediated Direct Acetylamination of 2-Arylpyridine C-H Bonds with Cyanate Salts

In this study, the coupling of 2-phenylpyridine derivatives and potassium cyanate through C-H bond functionalization in the presence of a copper salt is developed for the first time. By this protocol, various heteroarylated acetanilide derivatives are synthesized in good yields. 2-Phenylpyridines containing electron-donating and -withdrawing groups appear to be well-tolerated by this transformation.

Cobalt(III)-Catalyzed Directed C-H Coupling with Diazo Compounds: Straightforward Access towards Extended π-Systems

The first highly efficient and scalable cobalt-catalyzed directed C-H functionalization with carbene precursors is presented. This methodology provides a modular route towards a new class of conjugated polycyclic hydrocarbons with tunable emission wavelengths both in solution and in the solid state.

RhIII-Catalyzed C-H Activation with Pyridotriazoles: Direct Access to Fluorophores for Metal-Ion Detection

The first C-H bond activation with pyridotriazoles as coupling partners is presented using a RhIII catalyst. The pyridotriazoles can be used as new carbene precursors in C-H activation for direct access to novel fluorescent scaffolds. These tunable fluorophores can be applied for the detection of metal ions.

Copper-catalyzed direct C-H arylation of pyridine N-oxides with arylboronic esters: One-pot synthesis of 2-arylpyridines

The first example of the copper-catalyzed direct C-H arylation of pyridine N-oxides with arylboronic esters has been developed, leading to a wide range of 2-arylpyridines in a one-pot synthesis with moderate to good yields without an additional reductant. This transformation allows for rapid access to a variety of 2-arylpyridines using an inexpensive catalytic system that would be more difficult to access with traditional methods. Thus, this method represents a simple and practical procedure to access 2-arylpyridines.