59708-43-9

Basic information

• Product Name: 2,2-dimethoxyethyl benzoate
• Synonyms: 2,2-Dimethoxyethyl benzoate; ethanol, 2,2-dimethoxy-, benzoate
• CAS NO: 59708-43-9
• Molecular Formula: C₁₁H₁₄O₄
• Molecular Weight: 210.2265
• Mol File: 59708-43-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 235.186°C at 760 mmHg
• Flash Point: 93.777°C
• Density: 1.107g/cm³
• Vapor Pressure: 0.051mmHg at 25°C
• Refractive Index: 1.495
• CAS DataBase Reference: 2,2-dimethoxyethyl benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-dimethoxyethyl benzoate(59708-43-9)
• EPA Substance Registry System: 2,2-dimethoxyethyl benzoate(59708-43-9)

Safety Data

• Hazardous Substances Data: 59708-43-9(Hazardous Substances Data)

Usage

Usage as flavoring agent

Food and beverage industry It is commonly used to enhance the taste and aroma of various food and drink products.

Usage as fragrance ingredient

Perfumes and personal care products It is added to perfumes, lotions, and other personal care items to provide a pleasant scent.

Antioxidant properties

Potential benefits 2,2-dimethoxyethyl benzoate may help prevent the oxidation of other compounds, thus extending their shelf life and preserving their quality.

Antimicrobial properties

Potential benefits This chemical may exhibit antimicrobial activity, which can be useful in preventing the growth of bacteria, fungi, and other microorganisms in various products.

Applications in pharmaceuticals

Popular ingredient Due to its potential antioxidant and antimicrobial properties, 2,2-dimethoxyethyl benzoate is a popular ingredient in the pharmaceutical industry.

Applications in cosmetics

Popular ingredient It is also used in the cosmetic industry, likely due to its potential antioxidant and antimicrobial properties, as well as its pleasant scent.

Usage as solvent and plasticizer

Industrial applications 2,2-dimethoxyethyl benzoate is used as a solvent to dissolve other substances and as a plasticizer to increase the flexibility and workability of materials.

Upstream product

• 532-32-1 sodium benzoate 
• 7252-83-7 1-bromo-2,2-dimethoxyethane 
• 97-97-2 chloroacetaldehyde dimethyl acetal 
• 582-25-2 Potassium benzoate 

Downstream Products

• 1143490-94-1 N-[(2-benzoyloxy-1-tosyl)ethyl]urea 
• 67-56-1 methanol 
• 143338-44-7 2-[(phenylcarbonyloxy)methyl]-1,3-oxathiolane 
• 187996-10-7 Benzoic acid 4-chloromethyl-[1,3]dioxolan-2-ylmethyl ester 
• 240125-27-3 5-[(2S,4S)-(benzoyloxymethyl)-1,3-dioxolan-4-yl]-3-ethoxycarbonyl-1,2,4-triazole 
• 240125-28-4 5-[(2R,4S)-(benzoyloxymethyl)-1,3-dioxolan-4-yl]-3-ethoxycarbonyl-1,2,4-triazole 
• 240125-26-2 5-[(2R,4S)-2-(benzoyloxymethyl)-1,3-dioxolan-4-yl]-3-ethoxycarbonyl-1-benzyl-1,2,4-triazole 
• 240125-25-1 5-[(2S,4S)-2-(benzoyloxymethyl)-1,3-dioxolan-4-yl]-3-ethoxycarbonyl-1-benzyl-1,2,4-triazole 

Relevant articles and documents

Synthesis of functionalized tetrahydro-1,3-diazepin-2-ones and 1-carbamoyl-1H-pyrroles via ring expansion and ring expansion/ring contraction of tetrahydropyrimidines

A general approach to 6-phenylthio-substituted 2,3,4,5-tetrahydro-1H-1,3- diazepin-2-ones based on the ring expansion reaction of 1,2,3,4- tetrahydropyrimidin-2-ones under the action of nucleophiles has been developed. The first step of the synthesis was preparation of N-[(2-benzoyloxy-1-tosyl) ethyl]urea by three-component condensation of 2-benzoyloxyethanal, urea and p-toluenesulfinic acid. Nucleophilic substitution of the tosyl group in the obtained sulfone with sodium enolates of α-phenylthioketones followed by cyclization-dehydration, and debenzoylation gave 4-hydroxymethyl-5-phenylthio-1, 2,3,4-tetrahydropyrimidin-2-ones which were transformed into the 4-mesyloxymethyl-derivatives. Treatment of the latter with nucleophilic reagents, such as NaCN, sodium diethyl malonate, PhSNa, MeONa, NaBH4, sodium succinimide, or potassium phthalimide, afforded the target multi-functionalized diazepinones. The obtained 6-phenylthio-diazepinones and their 6-tosyl-substituted analogues were converted into 3-substituted 1-carbamoyl-1H-pyrroles under acidic conditions as a result of ring contraction. Effective one-pot synthesis of the latter from 4-mesyloxymethyl-pyrimidines was realized using a ring expansion/ring contraction sequence.

Process for producing 2-benzoyloxyacetaldehyde derivative

A process produces a 2-benzoyloxyacetaldehyde derivative represented by following Formula (3): wherein R1 and R2 may be the same as or different from each other and are each a hydrocarbon group, wherein R1 and R2 may be combined to form a ring with the adjacent oxygen-carbon-oxygen bond, and wherein the benzene ring in the formula may be substituted, by allowing a halogenated acetaldehyde acetal derivative represented by following Formula (1): wherein R1 and R2 are as defined above; and X represents a halogen atom, to react with a benzoate represented by following Formula (2): wherein M represents an alkali metal atom and wherein the benzene ring in the formula may be substituted, in the presence of an alkali-metal halide.

Synthesis, NMR spectroscopy study, and antimuscarinic activity of a series of 2-(acyloxymethyl)-1,3-dioxolanes

A series of 19-dioxolane-based ligands, bearing hydroxymethyl or ester functionalities, was synthesized and tested as potential muscarinic antagonists. The compounds display moderate to low affinity for the three receptor subtypes M1-M3/s