59744-46-6

Basic information

• Product Name: 3-Butenoic acid, 4-phenyl-, (Z)-
• CAS NO: 59744-46-6
• Molecular Formula: C10H10O2
• Molecular Weight: 162.188
• Mol File: 59744-46-6.mol
• Article Data: 61

Chemical Properties

• CAS DataBase Reference: 3-Butenoic acid, 4-phenyl-, (Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Butenoic acid, 4-phenyl-, (Z)-(59744-46-6)
• EPA Substance Registry System: 3-Butenoic acid, 4-phenyl-, (Z)-(59744-46-6)

Safety Data

• Hazardous Substances Data: 59744-46-6(Hazardous Substances Data)

Upstream product

• 124-38-9 carbon dioxide 
• 7217-71-2 1-phenyl-2-propenyl acetate 
• 51114-94-4 (2-carboxyethyl)triphenylphosphonium bromide 
• 100-52-7 benzaldehyde 
• 21087-29-6 trans-3-phenylprop-2-enyl chloride 
• 201230-82-2 carbon monoxide 
• 591-50-4 iodobenzene 
• 141-82-2 malonic acid 
• 122-78-1 phenylacetaldehyde 
• 108-86-1 bromobenzene 
• 147609-46-9 2-(2E)-(3-phenyl-2-propen-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 4407-36-7 (2E)-3-phenyl-2-propen-1-ol 
• 91083-82-8 (E)-methyl 4-phenylbut-3-enoate 
• 4392-24-9 Cinnamyl bromide 

Downstream Products

• 15732-89-5 (E)-2,2-dimethyl-4-phenylbut-3-enoic acid 
• 79164-23-1 (E)-2-methyl-4-phenylbut-3-enoic acid 
• 1205-84-1 ethyl (E)-4-phenylbut-3-enoate 
• 152978-83-1 (3R)-3-(4,4-dimethyl-2-oxotetrahydrofuranyl) (E)-4-phenyl-3-butenoate 
• 255384-80-6 (2Z,4E)-2,4-hexadienyl (E)-4-phenyl-3-butenoate 
• 53138-45-7 5-phenyl-2,5-dihydrofuran-2-one 
• 281190-96-3 (3E,1'R,2'S)-1'-[(p-tolylsulfonyl)amino]indan-2-yl 4-phenylbut-3-enoate 
• 91083-82-8 (E)-methyl 4-phenylbut-3-enoate 
• 1666-13-3 diphenyl diselenide 

Relevant articles and documents

Access to β-Lactams via Iron-Catalyzed Olefin Oxyamidation Enabled by the I -Accepting Phthalocyanine Ligand

Herein, we report the development of an iron-catalyzed olefin oxyamidation by utilizing tethered dioxazolones as the nitrenoid precursor to produce valuable β-lactam scaffolds. Mechanistic studies revealed that a relatively strong I -Accepting ability of

sEH Inhibitor or pharmaceutically acceptable composition thereof as well as preparation method and application thereof

The invention provides sEH inhibitor or a pharmaceutically acceptable composition and a preparation method and application thereof, and belongs to the technical field of medicines. sEH Inhibitor or a pharmaceutically acceptable composition thereof according to the present invention is provided, and the sEH inhibitor has the structure shown I. sEH Inhibitor provided by the invention can stabilize an endogenous substance epoxy fatty acid with wide physiological activity, has a strong inhibition effect on human recombinant sEH, and can be used for regulating the generation of a plurality of pro-inflammatory cytokines. The invention relieves the stress of endoplasmic reticulum, prevents or reverses the dysfunction of endothelial dysfunction, stabilizes mitochondria function multiple action mechanisms to obviously relieve neuropathic pain, and can effectively avoid adverse reactions related to the target spot. Furthermore, the sEH inhibitor structure provided by the invention does not contain free carboxyl groups, can avoid adverse reactions such as gastrointestinal irritation caused by oral administration, and is small in adverse reaction, high in bioavailability, excellent in analgesic effect and small in administration amount.

Palladium-Catalyzed Direct C-H Arylation of 3-Butenoic Acid Derivatives

We report herein a direct method to synthesize 4-aryl-3-butenoic acid through a carboxylic-acid-directed oxidative Heck reaction. The various 4-aryl-3-butenoic acids are easily prepared in moderate to good yields. In view of the promising bioactivity of 4-phenyl-3-butenoic acid previously reported, its derivatives reported here may be bioactive.