598-80-1Relevant articles and documents
A NEW SYNTHESIS OF α-IODO CARBOXYLIC ACID USING IODINE-COPPER SALT
Horiuchi, C. Akira,Satoh, J. Yasuo
, p. 1509 - 1510 (1984)
Direct α-iodination of some carboxylic acids, namely, acetic acid, propionic acid, butyric acid, and valeric acid, using iodine-copper salt, gave the corresponding α-iodo carboxylic acid in high yield.This new synthetic method afforded several advantage over classical α-iodo carboxylic acid procedures.
Oxidative Coupling of Carboxylic Acid Dianions: The Total Synthesis of (+/-)-Hinokinin and (+/-)-Fomentaric Acid
Belletire, John L.,Fry, Douglas F.
, p. 2549 - 2555 (2007/10/02)
The oxidative coupling of carboxylic acid dianion derivatives provides the key intermediates needed for efficient syntheses of the symmetrical lignan hinokinin (9) and the unsymmetrical fungal metabolite fomentaric acid (22).Racemic hinokinin (9), a targed chosen to test the facility of dianion oxidative coupling in the presence of electron-rich aromatic rings, is prepared in an overall conversion of 61 percent from 3,4-(methylenedioxy)hydrocynnamic acid.Racemic fomentaric acid (22), a trisubstituted succinic acid derivative, results from a straightforward two-stepsequence that proceeds in an overall yield of 40 percent from eicosanoic acid.Preliminary studies demonstrate the utility of oxidative coupling in the synthesis of novel surfactant prototypes.