59807-17-9Relevant academic research and scientific papers
Iron-Catalyzed Alkyne-Based Multicomponent Synthesis of Pyrimidines under Air
Chakraborty, Gargi,Guin, Amit Kumar,Mondal, Rakesh,Paul, Nanda D.,Sarkar, Susmita
, p. 13186 - 13197 (2021/10/01)
An iron-catalyzed sustainable, economically affordable, and eco-friendly synthetic protocol for the construction of various trisubstituted pyrimidines is described. A wide range of trisubstituted pyrimidines were prepared using a well-defined, easy to prepare, bench-stable, and phosphine-free iron catalyst featuring a redox-noninnocent tridentate arylazo pincer under comparatively mild aerobic conditions via dehydrogenative functionalization of alcohols with alkynes and amidines.
Metal-free cascade synthesis of unsymmetrical 2-aminopyrimidines from imidazolate enaminones
Cui, Xue,Li, Youbin,Ma, Jianting,Wang, Xuesong,Xu, Junyu,Zeng, Tingting
, p. 24247 - 24253 (2021/07/29)
A convenient metal-free synthesis of unsymmetrical 2-aminopyrimidines from imidazolate enaminones has been developed. In this procedure, various structural 2-aminopyrimidines, as well as 4,5-dihydroisoxazol-5-ols and pyrazoles were synthesized in moderate to excellent yields. A plausible mechanism was also proposed for the cascade reaction. This method represents an effective strategy towards the synthesis of unsymmetrical 2-aminopyrimidines.
CsOH/γ-Al2O3: A heterogeneous reusable basic catalyst for one-pot synthesis of 2-amino-4,6-diaryl pyrimidines
Nimkar, Amey,Ramana,Betkar, Rahul,Ranade, Prasanna,Mundhe, Balaji
, p. 2541 - 2546 (2016/03/22)
A new strategy for a one-pot synthesis of 2-amino-4, 6-diaryl pyrimidines using CsOH/γ-Al2O3 as a heterogeneous, reusable basic catalyst is presented. The developed synthetic protocol for pyrimidines is a one-pot three-component reac
2-Aminopyrimidines as dual adenosine A1/A2A antagonists
Robinson, Sarel J.,Petzer, Jacobus P.,Terre'Blanche, Gisella,Petzer, Anél,Van Der Walt, Mietha M.,Bergh, Jacobus J.,Lourens, Anna C.U.
, p. 177 - 188 (2015/10/28)
In this study thirteen 2-aminopyrimidine derivatives were synthesised and screened as potential antagonists of adenosine A1 and A2A receptors in order to further investigate the structure activity relationships of this class of compo
Synthesis, characterization of 4,6-disubstituted aminopyrimidines and their sulphonamide derivatives as anti-Amoebic agents
Siddiqui, Shadab Miyan,Azam, Amir
, p. 2976 - 2984 (2014/05/06)
The present study describes the synthesis and anti-Amoebic activity of 4,6-disubstituted aminopyrimidines (1b-10b) and their sulphonamide derivatives (1-20). All the desired compounds were characterized by spectral data and their purity was confirmed by e
Synthesis and spectral analysis of novel 3-(4,6-diarylpyrimidin-2-yl)-2- phenylthiazolidin-4-ones
Gopalakrishnan,Thanusu,Kanagarajan
body text, p. 1539 - 1544 (2010/07/09)
Novel 3-(4,6-diarylpyrimidin-2-yl)-2-phenylthiazolidin-4-ones are synthesized by the multicomponent cyclocondensation reaction of the appropriate 2-amino-4,6-diarylpyrimidines, benzaldehyde, and thioglycolic acid catalyzed by dicyclohexylcarbodiimide. The
Synthesis of N-tetra-O-acetyl-β-d-glucopyranosyl-N′-(4′,6′-diarylpyrimidin-2′-yl)thioureas
Thanh, Nguyen Dinh,Mai, Nguyen Thi Thanh
experimental part, p. 2399 - 2405 (2010/01/18)
Some 2-amino-4,6-diarylpyrimidines 2 have been prepared from substituted benzylideneacetophenones and guanidine hydrochloride in the presence of alkali by conventional heating in alcoholic medium and microwave heating in solvent-free conditions. N-(2,3,4,
Reaction of α,β-Unsaturated Ketones with Guanidine. Substituent Effects on the Protonation Constants of 2-Amino-4,6-diarylpyrimidines
Al-Hajjar, Farouk H.,Sabri, Salim S.
, p. 1087 - 1092 (2007/10/02)
1.3-Diaryl-2-propen-1-ones, I, reacted with guanidine hydrochloride (II) in the presence of 3 moles of sodium hydroxide to give the corresponding 2-amino-4,6-diarylpyrimidines, III.The structure and configuration of the products are based on chemical and
